Journals / Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2003 / Cilt: 43 - Sayı: 4

The effects of the DHB, midazolam and clonidin premedication on the hemodynamics and the requirement of anaesthetic dose

Dehidrobenzperidol, midazolam ve klonidin premedikasyonunun hemodinami ve anestezik doz gereksinimine etkileri

Pages
216–219
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was concluded that clonidin is a good alternative for premedication.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of the preoperative medication is to prevent of the anxiety and the otonomic reflexes at the general anaesthesia, to provide the hemodynamic stability and to reduce the anaesthetic dose.
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Key Findings & Data:In this study it was aimed to compare the effects of DHB, M and C premedications on hemodynamic stability and anaesthetic requirement Patients aged between 1870 years old, ASA I-Il class were randomly divided into three groups.
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Conclusion & Impact:It was concluded that clonidin is a good alternative for premedication.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of the preoperative medication is to prevent of the anxiety and the otonomic reflexes at the general anaesthesia, to provide the hemodynamic stability and to reduce the anaesthetic dose. In this study it was aimed to compare the effects of DHB, M and C premedications on hemodynamic stability and anaesthetic requirement Patients aged between 1870 years old, ASA I-Il class were randomly divided into three groups. Group I were received DHB 40 mcg/kg, Group Il were received M 15 mcg/kg Group III were received C 4 mcg/kg intravenously. The induction of anaesthesia was performed with Fentanyl 1 meg / kg and tiopental with eyelash reflex. The entubation was performed with vecuronium 0.1 mg/kg . Requirement of the tiopental dose, hemodynamic parameter and adverse effects were recorded. After the administration of drugs heart rate and blood pressure decreased in Group Il and III. Hemodynamic stability was provided in Group III only. Although there was no significant differences at tiopental dose between the groups, it was lowest clinically in Group III. It was concluded that clonidin is a good alternative for premedication.

Özet

Preoperatif medikasyon preoperatif dönemde hastada korku ve endişeyi gidermek, genel anestezi sırasında otonom refleksleri önleyerek hemodinamik stabiliteyi sağlamak, anestezik doz gereksinimini azaltmak amacıyla yapılır. Bu çalışmada elektif operasyon planlanan ASA l-ll, 18-70 yaş arası hastalarda, dehidrobenzperidol (DHB), midazolam ve klonidin premedikasyonunun anestezi indüksiyonunda hemodinamik stabiliteye ve anestezik gereksinimine etkilerinin karşılaştırılması amaçlandı. Hastalar rasgele 3 gruba ayrılarak Grup l'de 40 mcg/kg DHB, Grup ll'de 15 mcg/kg midazolam, Grup lll'de 4 mcg/kg klonidin IV verildi. 1 mcg/kg fentanil, kirpik refleksi kaybolana kadar 10 mg/sn hızda tiyopental verilip, 0,1 mg/kg vekuronyum ile entübasyon sağlandı. Tiyopental gereksinimi, hemodinamik parametreler ve yan etkiler kaydedildi. Karşılaştırılan ilacın verilmesini takiben Grup Il ve III' de kalp atım hızı ve kan basınçlarının düştüğü, entübasyon sonrasında ise hemodinamik stabilitenin sadece Grup III' de korunabildiği görüldü, istatistiksel anlam olmasa da Grup III' de daha az tiyopental gerektiği gözlendi. Klonidinin premedikasyon için uygun bir alternatif olabileceği kanaatine varıldı.

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Cite This Article

BOSNA, G., AYDIN, N., EKİM, M. Ş., BAYRAM, K. H. (2022). The effects of the DHB, midazolam and clonidin premedication on the hemodynamics and the requirement of anaesthetic dose. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 43 - Sayı: 4, 216–219. https://ajindex.com/articles/535710

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