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Journals / Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2002 / Cilt: 42 - Sayı: 3

Anesthetic approach in Ochronosis

Okronozisli hastalarda anestezik yaklaşım (Olgu sunumu)

Gülşen BOSNA
Serhan ÇOLAKOĞLU
Neşe AYDIN
Pages
53–56
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The purpose of this case report is to review the anesthetic app-roach in ochronosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ochronosis, a rare inherited disease of tyrosine metabolism, is caused by a deficiency of the enzyme, homogentisic acid oxidase.
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Key Findings & Data:Homogentisate polymers are accumulated and cause urine darkening (alcaptonuria), brown/black pigmen-tation of connective tissue (ochronosis), articular cartilage pathology, osteoporosis and patomorp-hologic changes in internal organs.
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Conclusion & Impact:The purpose of this case report is to review the anesthetic app-roach in ochronosis.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Ochronosis, a rare inherited disease of tyrosine metabolism, is caused by a deficiency of the enzyme, homogentisic acid oxidase. Homogentisate polymers are accumulated and cause urine darkening (alcaptonuria), brown/black pigmen-tation of connective tissue (ochronosis), articular cartilage pathology, osteoporosis and patomorp-hologic changes in internal organs. The purpose of this case report is to review the anesthetic app-roach in ochronosis.

Özet

Okronozis, homojentizik asid oksidaz enziminin eksikliği nedeniyle tirozin metabolizmasındaki bozukluğa bağlı, seyrek rastlanan otozomal resesif geçişli bir hastalıktır. Homojentizik asid polimerleri birikerek koyu idrar (alkaptonuri), bağ dokusunda kahverengi/siyah pigmentasyon (okronozis), dejeneratif osteoartrit, osteoporoz ve iç organlarda patomorfolojik değişiklikler yaparlar. Bu olgu sunumunun amacı okronozisli hastalarda anestezik yaklaşımı gözden geçirmektir.

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Cite This Article

BOSNA, G., ÇOLAKOĞLU, S., AYDIN, N. (2022). Anesthetic approach in Ochronosis. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 42 - Sayı: 3, 53–56. https://ajindex.com/articles/535787

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References (16)

  1. Lloyd H, Smith Jr. Metabolizma Hastalıkları. Çeviri Ülkü A. In: Wintrobe MM, Thorn GW, Adams RD (eds),Harrison İç Hastalıklarında Temel Bilgiler, Çeviri ed:MenteşNK, İzmir, Menteş Kitabevi, 1981;742-821
  2. Kuntz D, Bardin T. Ochronosis. Klippel JH, Dieppne PA (eds), Rheumatology, Sekond Edition, London,Mosby 2000;8.28.1-8.28.4 3. Rodriguz JM, Timm DE, Titus GP et all. Structural and functional analysis of mutations in alkaptonuria.Hum Mol Genel 2000;9(15): 2341-50
  3. Cramer P, Loughlin J. Genetic Factors in Rheumatic Disease. Klippel JH, Dieppe PA (eds), Rheumatology,Second Edition, London, Mosby 2000; 1.6.1-1.6.8
  4. Yenerman M. Genel Patoloji, Istanbul, Çelikler Basımevi 1980;414-415
  5. Koçyiğit H, Gürgen A, Terzioğlu R et all. Clinical,radiographic and echocardiographic findings in a patient with ochronosis. Clin. Rheumatol 1998; 17(5),403-6
  6. Droste U. Pararomatizmal Hastalıklar. Çeviri. Arman Ml. In: Hettenkofer HJ (ed). Romatoloji Diagnostik-Klinik-Terapi Çeviri ed: Arman Mİ, İstanbul, Arkadaş Tıp Kitapları. 1986;265-340
  7. Buchanan WW, Dequeker J. Hystory of Rheumatic Diseases. Klippel JH, Dieppe PA (eds), Rheumatology,Second Edition, London, Mosby 2000;1.1.1-1.1.6
  8. Kusakabe N, Tsuzuki N, Sonada M. Compression of the cervical cord due to alcaptonwic arthropathy of the atlanto-axial joint. A case report, J Bone Joint Surg 1995;77(2), 274-7
  9. Rebuck AS, Braude AC. Gray airways in ochronosis, N Engl J Med 1981; 304(22), 1367
  10. Kayhan Z. Klinik Anestezi, İstanbul, Logos Yayıncılık 1997; 63-68
  11. Doi M, Ikeda K. Airway irritation produced by volatile anesthetics during brief inhalation: Comparison of halotane, enflurane, isoflurane and sevoflurane. Can. J.Anaesth. 1993;40(2):122
  12. Patel SS, Goa KL. Sevoflurane: A review of its pharmacodynamic and pharmacokinetic properties and its clinical use in general anaesthesia. Drugs 1996; 51(4):658
  13. Sloan MH, Conard PF, Karsunky PK, Gross JB.Sevoflurane versus isoflurane: induction and recovery characteristics with single-breath inhaled inductions of anaesthesia. Anesth. Analg. 1996;82:528
  14. Yurino M, Kimmura H. Induction of anesthesia with sevoflurane, nitrous oxide, and oxygen: A comparison of spontaneous ventilation and vital capacity rapid inhalation induction (VCRII) techniques. Anesth. Analg. 1993;76:598
  15. Berkmen R. Metabolizma Hastalıkları ve Avitaminozlarlarda Kalb ve Dolaşım Sistemi. Özcan R (ed.). Kalb Hastalıkları, Bayda BYD A.Ş. 1983;975-980
  16. Gould L, Roddy CV, DeP