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Journals / Hacettepe Journal of Biology and Chemistry / 2021 / Cilt: 49 - Sayı: 1

The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis

Akut Apandisitlerde Hücresel Antioksidan Savunma Sisteminin Oksidatif Stres Üzerindeki Rolü

Yeliz DEMİR
Ayetullah TEMİZ
Ayşe ALBAYRAK
Yavuz ALBAYRAK
Şükrü BEYDEMİR
Mesut IŞIK
Hatice Esra DURAN
Adem ASLAN
Yılmaz ÖZDEMİR
Pages
69–78
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Malondialdehyde (MDA) levels in acute perforated appendicitis (PeA) groups were found significantly higher than control (p

📌 3 Key Takeaways

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Objective & Hypothesis:It is known that free radicals, their products and reactive oxygen species (ROS) are associated with many diseases.
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Key Findings & Data:The study focuses on both some changes in oxidative stress factors in patients with acute appendicitis (AA) and the changes of glutathione S-transferase (GST) and paraoxonase-I (PON1) enzyme activities in the metabolism.
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Conclusion & Impact:Malondialdehyde (MDA) levels in acute perforated appendicitis (PeA) groups were found significantly higher than control (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

It is known that free radicals, their products and reactive oxygen species (ROS) are associated with many diseases. The study focuses on both some changes in oxidative stress factors in patients with acute appendicitis (AA) and the changes of glutathione S-transferase (GST) and paraoxonase-I (PON1) enzyme activities in the metabolism. This study involved control group (n = 31) and the study group (n = 52). In the groups, some changes in oxidative stress factors and GST and PON1 enzyme activities which play an important role in metabolism were determined. There are changes in GST activity between study and control groups. The activity of the enzyme were significantly higher in AA groups (p < 0.01) than control. Malondialdehyde (MDA) levels in acute perforated appendicitis (PeA) groups were found significantly higher than control (p

Özet

Serbest radikallerin, ürünlerinin ve reaktif oksijen türlerinin (ROS) birçok hastalıkla ilişkili olduğu bilinmektedir. Çalışmahem akut apandisitli (AA) hastalarda oksidatif stres faktörlerindeki hem de metabolizmada GST ve PON1 enzimaktivitelerindeki değişikliklere odaklanmaktadır. Bu çalışmaya kontrol grubu (n = 31) ve çalışma grubu (n = 52) dahil edildi.Gruplarda, metabolizmada önemli rol oynayan oksidatif stres faktörleri ve Glutatyon S-transferaz (GST) and paraoksanaz-I(PON1) enzim aktivitelerinde bazı değişiklikler belirlendi. Çalışma ve kontrol grupları arasında GST aktivitesinde önemlideğişiklikler belirlenmiştir. Bu enzim aktivitesi AA gruplarında (p

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Cite This Article

DEMİR, Y., TEMİZ, A., ALBAYRAK, A., ALBAYRAK, Y., BEYDEMİR, Ş., IŞIK, M., DURAN, H. E., ASLAN, A., ÖZDEMİR, Y. (2022). The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis. Hacettepe Journal of Biology and Chemistry, Cilt: 49 - Sayı: 1, 69–78. https://ajindex.com/articles/528945

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