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Journals / Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research) / 2002 / Cilt: 26 - Sayı: 3-4

Kronik periodontitiste sistemik Doksisiklin'in klinik iyileşme ve dişeti oluğu sıvısı hidroksiprolin ve total protein düzeylerine etkileri

The effects of systemic Doxycycline on clinical healing and Gingival crevicular fluid hydroxyproline and total protein levels in patients with chronic periodontitis

Esra BALTACIOĞLU
Nurten RENDA
F. Alev AKALAN
Dilek ŞENGÜN
İlker ETİKAN
Pages
29–40
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

All treatments significantly reduced clinical parameters and Hyp and TP levels (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Recently, non-antimicrobial properties of tetracyclines, such as increasing collagen synthesis and decreasing collagen breakdown have been shown.
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Key Findings & Data:Fifteen patients received only SD treatment in 1 qua-drant of upper jaws and SD+SRP in the contralateral quadrant.
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Conclusion & Impact:All treatments significantly reduced clinical parameters and Hyp and TP levels (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Recently, non-antimicrobial properties of tetracyclines, such as increasing collagen synthesis and decreasing collagen breakdown have been shown. In this study; the effects of systemic doxycycline (SD) alone and combined with scaling-root planing (SD+SRP) and SRP alone on cli-nical healing and gingival crevicular fluid (GCF) hydroxy-proline (Hyp: a marker of collagen) and total protein (TP) levels in chronic periodontitis patients were evaluated. Fifteen patients received only SD treatment in 1 qua-drant of upper jaws and SD+SRP in the contralateral quadrant. Fifteen patients received only SRP treatment. Probing depth (PD), clinical attachment level (CAL), gin-gival, sulcular bleeding and plaque indices (GI, SBI, PI) were recorded and GCF samples were collected at baseli-ne and 7th week. Hyp and TP levels were biochemically determined The results were statistically analyzed. All treatments significantly reduced clinical parameters and Hyp and TP levels (p

Özet

Son yıllarda tetrasiklinlerin, kollagen sentezini artırmak ve yıkımını azaltmak gibi non-antimikrobiyal etkileri gösterilmiştir. Bu çalışmada, tek başına ve detartraj ve kök düzeltmesi (DKD) ile kombine sistemik doksisiklinin (SD, SD+DKD), klinik iyileşme ve dişeti oluğu sıvısı (DOS) hidroksiprolin (Hyp: kollagen göstergesi) ve total protein (TP) düzeylerine etkileri değerlendirilmiştir. Onbeş hastada üst çenede l kuadranta sadece SD, diğer kuadranta SD+DKD, 15 hastada sadece DKD uygulandı. Başlangıçta ve 7. haftada cep derinliği (CD), klinik ataçman düzeyi (KAD), gingival, sulkuler kanama, plak indeksleri (GI, SKt, PI) ölçüldü, DOS örnekleri toplandı. Hyp ve TP düzeyleri biyokimyasal olarak saptandı. Sonuçlar istatistiksel olarak değerlendirildi. Tüm tedavilerle, klinik parametreler, Hyp ve TP düzeyleri önemli derecede azaldı (p

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Cite This Article

BALTACIOĞLU, E., RENDA, N., AKALAN, F. A., ŞENGÜN, D., ETİKAN, İ. (2022). Kronik periodontitiste sistemik Doksisiklin'in klinik iyileşme ve dişeti oluğu sıvısı hidroksiprolin ve total protein düzeylerine etkileri. Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research), Cilt: 26 - Sayı: 3-4, 29–40. https://ajindex.com/articles/528640

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