SavedAdd your journal

Journals / Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research) / 2002 / Cilt: 26 - Sayı: 3-4

Orta düzeyde periodontitis tedavisinde lokal doksisiklin'in klinik etkinliği

The clinical efficiency of local Doxycycline in the treatment of moderate chronic periodontitis

Esra BALTACIOĞLU
F. Alev AKALIN
Dilek ŞENGÜN
Süeda HEKİMOĞLU
Müge TAŞKIN
İlker ETİKAN
Pages
41–52
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

All parameters significantly reduced by all treatments (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, the clinical efficacy of local doxycycline (LD) in the treatment of moderate periodontitis was evaluated.
📊
Key Findings & Data:Two groups, each including 15 patients were studied: LD and SRP groups, LD patients received only LD treatment in 1 quadrant of maxilla and LD+SRP in the contralateral quadrant.
💡
Conclusion & Impact:All parameters significantly reduced by all treatments (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, the clinical efficacy of local doxycycline (LD) in the treatment of moderate periodontitis was evaluated. Clinical results of LD alone and combined with scalingroot planing (LD+SRP) versus SRP alone were compared. Two groups, each including 15 patients were studied: LD and SRP groups, LD patients received only LD treatment in 1 quadrant of maxilla and LD+SRP in the contralateral quadrant. SRP group received only SRP treatment in 1 quadrant of maxilla. Probing depth (PD), clinical attachment level (CAL), gingival index (GI), sulcular bleeding index (SBI), plaque index (PI) were recorded at baseline and 7th week. The results were statistically analyzed. All parameters significantly reduced by all treatments (p

Özet

Bu çalışmada, orta düzeydeki kronik periodontitis tedavisinde; lokal doksisiklin'in (LD) klinik etkileri değerlendirilmiştir. Tek başına ve subgingival küretajla kombine (LD+SGK) ve sadece SGK sonuçları karşılaştınlmıştır. Onbeş'er hasta içeren 2 grup çalışılmıştır: LD grubu, SGK grubu. LD hastalarında, üst çenede l kuadranta sadece LD, diğer kuadranta LD+SGK uygulanmıştır. SGK grubunda, üst çenede l kuadranta sadece SGK yapılmıştır. Cep derinliği (CD), klinik ataçman düzeyi (KAD), gingival indeks (Gî), sulkuler kanama indeksi (SKİ), plak indeksi (Pl), başlangıçta ve 7. haftada ölçülmüştür. Sonuçlar istatistiksel olarak değerlendirilmiştir. Tüm tedaviler, parametreleri önemli derecede azaltmıştır (p

🔖

Cite This Article

BALTACIOĞLU, E., AKALIN, F. A., ŞENGÜN, D., HEKİMOĞLU, S., TAŞKIN, M., ETİKAN, İ. (2022). Orta düzeyde periodontitis tedavisinde lokal doksisiklin'in klinik etkinliği. Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research), Cilt: 26 - Sayı: 3-4, 41–52. https://ajindex.com/articles/528635

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Page R. The role of inflammatory mediators in the pat¬hogenesis of periodontal disease. J. Periodont. Res. 1991; 26:230-242
  2. Birkedal HH. Role of cytokines and inflammatory medi¬ators in tissue destruction. J. Periodont. Res. 1993; 28:500-510
  3. Slots J, Rams TE. Antibiotics in periodontal therapy: Advantages and disadvantages. J. Clin. Periodontol. 1990; 17:479-493
  4. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodonto-logy 2000. 5:78-111
  5. Lang NP, Karring T, Lindhe J. Proceedings of the 2nd European Workshop on Periodontology. Chemicals in Periodontics. Quintessenz. Berlin 1997; 38-77 6. Hirschfeld L, Wasserman B. A long-term survey of to¬oth loss in 600 treated periodontal patients. J. Peri¬odontol. 1978; 49:225-237
  6. Ciancio SG, Mather ML, McMullen JA. An evaluation of minocycline in patients with periodontal disease. J. Periodontol. 1980; 51:530-534
  7. Gordon JM, Walker CB, Murphy JC, Goodson JM, Socransky SS. Concentration of tetracycline in human gingival fluid after single doses. J. Clin. Periodontol. 1981;8:117-121
  8. Pascale P, Gordon J, Lamster I, Mann P, Selger M, Ar-nolt W. Concentration of doxycycline in human gingival fluid. J. Clin. Periodontol. 1986; 13:841-844
  9. Slots J, Rosling BG. Suppression of the periodontopat-hic microflora in localized juvenile periodontitis by syste¬mic tetracycline. J. Clin. Periodontol. 1983; 10:465-486
  10. Golub LM, McNamara TF, D'Angelo G, Greenwald RA, Ramamurthy NS. A non-antimicrobial chemically modified tetracycline inhibits mammalian collagenase activity. J. Dent. Res. 1987; 66:1310-1314
  11. Golub LM, Wolff M, Lee HM and et al. Further eviden¬ce that tetracyclines inhibit collagenase activity in hu¬man crevicular fluid and from other mammalian sour¬ces. J. Periodont. Res. 1985; 20:12-23
  12. Golub LM, Ciancio S, Ramamurthy NS, Leung M, McNamara TF. Low-dose doxycycline therapy: Effect on gingiva and crevicular fluid collagenase in humans. J. Periodontol. 1990; 25:321-330
  13. Golub LM, Lee HM, Ryan ME and et al. Tetracyclines inhibit connective tissue breakdown by multiple non-an¬timicrobial mechanisms. Adv Dent Res. 1998; 12:12-26
  14. Burns FR, Stack MS, Gray RD et al. Inhibition of puri¬fied collagenase from alkaline-burned rabbit corneas. In¬vest. Ophthalmol. Vis. Sci. 1989; 30:1569-1575
  15. Goodson JM, Hogan PE, Dunham SL. Clinical respon¬se following periodontal treatment by local drug deli¬very. J. Periodontol. 1985; 56(Suppl.