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Journals / Hacettepe Journal of Biology and Chemistry / 2019 / Cilt: 47 - Sayı: 2

Naproxen Derivative Interaction Properties with ct-DNA

Naproksen Türevi ile ct-DNA’nın Etkileşim Özellikleri

Tuğba TAŞKIN TOK
Nuriye AKBAY
Zeynep KÖKSAL
Ayşe UZGOREN BARAN
Pages
177–184
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition to spectral data,docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trendsto each DNA isomer.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Interaction mode of a naproxen derivative (NH) with ct-DNA was explored by absorption and fluorescence spectroscopy.The experimental results revealed the static quenching as a result of groove binding between the naproxen derivativeand ct-DNA.
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Key Findings & Data:Computational studies were carried out to a deeper understanding of the interactions.
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Conclusion & Impact:In addition to spectral data,docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trendsto each DNA isomer.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Interaction mode of a naproxen derivative (NH) with ct-DNA was explored by absorption and fluorescence spectroscopy.The experimental results revealed the static quenching as a result of groove binding between the naproxen derivativeand ct-DNA. Computational studies were carried out to a deeper understanding of the interactions. Molecular dockingcalculations showed that the interaction between NH and ct-DNA is resulted by groove binding. In addition to spectral data,docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trendsto each DNA isomer.

Özet

Naproksenin bir türevi (NH) ile ct-DNA’nın etkileşim türü absorpsiyon ve floresans spektroskopisi ile incelendi. Deneysel sonuçlar, naproksen türevi ile ct-DNA arasında oluğa bağlanma sonucunda statik sönüm gerçekleştiğini ortaya koymuştur. Hesaplamalı yöntemler de etkileşimin daha detaylı anlaşılması için kullanılmıştır. Moleküler kenetlenme hesaplamaları, NH ve ct-DNA arasındaki etkileşimin oluğa tutunma üzerinden olduğunu göstermiştir. Spektral verilere ek olarak, kenetlenme çalışmaları NH-A_DNA ve NH-B_DNA komplekslerinin her bir DNA izomerine özgü farklı etkileşim ve konformasyon eğilimlerine sahip olduğunu göstermiştir.

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Cite This Article

TOK, T. T., AKBAY, N., KÖKSAL, Z., BARAN, A. U. (2022). Naproxen Derivative Interaction Properties with ct-DNA. Hacettepe Journal of Biology and Chemistry, Cilt: 47 - Sayı: 2, 177–184. https://ajindex.com/articles/527417

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