Journals / Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi / 2018 / Cilt: 32 - Sayı: 3

Effects of Flunixin Meglumine and Chrysin on Some Blood Parameters of Rats with Induced Copper Sulphate Toxicity

Bakır Sülfat Toksisitesi Oluşturulan Ratlarda Krisin ve Fluniksin Meglumin’in Kan Parametreleri Üzerine Etkileri

Pages
197–201
Publication Date
2022-10-18
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Thirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups; Control, Copper Sulphate (Cu; 500 ppm body weight (BW/day, gavage), Flunixin Meglumine (FM; 2.2 ppm BW/day, intraperitoneal injection (ip)), Chrysin (Chrysin; 50 ppm BW/day, gavage), Copper Sulphate+Flunixin Meglumine (Cu+FM; 500 ppm BW/day of copper sulphate, gavage and 2.2 ppm BW/day of flunixin meglumine, ip) and Copper Sulphate+Chrysin (Cu+Chrysin; 500 ppm BW/day of copper sulphate, gavage and 50 ppm BW/day of chrysin, gavage).

📌 3 Key Takeaways

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Objective & Hypothesis:This experiment was conducted to determine the effects of chrysin and flunixin meglumine on some blood parameters in rats exposed to excess copper.
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Key Findings & Data:This experiment was conducted to determine the effects of chrysin and flunixin meglumine on some blood parameters in rats exposed to excess copper.
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Conclusion & Impact:Thirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups; Control, Copper Sulphate (Cu; 500 ppm body weight (BW/day, gavage), Flunixin Meglumine (FM; 2.2 ppm BW/day, intraperitoneal injection (ip)), Chrysin (Chrysin; 50 ppm BW/day, gavage), Copper Sulphate+Flunixin Meglumine (Cu+FM; 500 ppm BW/day of copper sulphate, gavage and 2.2 ppm BW/day of flunixin meglumine, ip) and Copper Sulphate+Chrysin (Cu+Chrysin; 500 ppm BW/day of copper sulphate, gavage and 50 ppm BW/day of chrysin, gavage).
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This experiment was conducted to determine the effects of chrysin and flunixin meglumine on some blood parameters in rats exposed to excess copper. Thirty-six Sprague Dawley male rats were housed in individual cages and randomly divided into six groups; Control, Copper Sulphate (Cu; 500 ppm body weight (BW/day, gavage), Flunixin Meglumine (FM; 2.2 ppm BW/day, intraperitoneal injection (ip)), Chrysin (Chrysin; 50 ppm BW/day, gavage), Copper Sulphate+Flunixin Meglumine (Cu+FM; 500 ppm BW/day of copper sulphate, gavage and 2.2 ppm BW/day of flunixin meglumine, ip) and Copper Sulphate+Chrysin (Cu+Chrysin; 500 ppm BW/day of copper sulphate, gavage and 50 ppm BW/day of chrysin, gavage). Glucose (P

Özet

Bu araştırma, aşırı bakıra maruz bırakılmış ratlarda krisin ve fluniksin meglumin’in, bazı kanparametreleri üzerine etkilerini belirlemek amacıyla yapıldı. Araştırmada bireysel olarak barındırılan36 adet erkek Sprague-Dawley rat; Kontrol, Bakır Sülfat (Cu, 500 ppm canlı ağırlık (BW)/gün,gavaj), Fluniksin Meglumin (FM; 2,2 ppm BW/gün, periton içi (ip)), Krisin (Krisin, 50 ppm BW/gün,gavaj), Bakır Sülfat+Fluniksin Meglumin (Cu+FM; 500 ppm BW/gün bakır sülfat, gavaj ve 2,2 ppmBW/gün fluniksin meglumin, ip) ve Bakır Sülfat+Krisin (Cu+Krisin 500 ppm BW/gün bakır sülfat,gavaj ve 50 ppm BW/gün krisin, gavaj) olarak rastgele altı gruba ayrıldı. Kontrol, FM, Krisin,Cu+FM ve Cu+Krisin gruplarında serum glikoz (P

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Cite This Article

BAYKALIR, B. G., SEVEN, P. T., SEVEN, İ., GÜLLÜOĞLU, H. (2022). Effects of Flunixin Meglumine and Chrysin on Some Blood Parameters of Rats with Induced Copper Sulphate Toxicity. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi, Cilt: 32 - Sayı: 3, 197–201. https://ajindex.com/articles/514929

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References (14)

  1. Sönmez S, Kaplan M, Sönmez NK, Kaya H. Topraktan yapılan bakır uygulamalarının toprak pH’sı ve bitki besin maddesi içerikleri üzerine etkisi. Akdeniz Üniversitesi Ziraat Fakültesi Dergisi 2006; 19: 151-158. Kaplan M. Accumulation of copper in soils and leaves of tomato plants in greenhouses in Turkey. Journal of Plant Nutrition 1999; 22: 237-244.
  2. Anonim. “Toxicological profile for copper”. https://www. atsdr.cdc.gov/toxprofiles/tp132.pdf/23/07/2018.
  3. Ozcelik D, Uzun H. Copper Intoxication; antioxidant defences and oxidative damage in rat brain. Biol Trace Elem Res 2009; 127: 45-52.
  4. Sokol RJ, Devereaux MW, O'Brien K, Khandwala RA, Loehr JP. Abnormal hepatic mitochondrial respiration and cytochrome C oxidase activity in rats with long-term copper overload. Gastroenterology 1993; 105: 178-187.
  5. Sultana S, Verma K, Khan R. Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. Journal of Pharmacy and Pharmacology 2012; 64: 872-881.
  6. Traş B, İzci C, Elmas M. Fluniksin meglumin (FinadynR)'in eklem sıvısına geçiş oranının belirlenmesi. Vet Bil Derg 1995; 11: 65-66.
  7. Luthman J, Kindahl H, Jacobsson SO. The influence of Fluniksin on the response to Salmonella typhimurium endotoxin in calves. Acta Vet Scand 1989; 30: 295-300.
  8. Daels PF, Stabenfeldt GH, Hughes JP, et al. Effects of Fluniksin meglumine on endotoxin-induced prostaglandin F2 alpha secretion during early pregnancy in mares. Am J Vet Res 1991; 52: 276-281.
  9. Toutain PL, Autefage A, Legrand C, et al. Plasma concentrations and therapeutic efficacy of phenylbutazone and Fluniksin meglumine in the horse: Harmacokinetic/pharmacodynamic modelling. J Vet Pharmacol Ther 1994; 17: 459-469.
  10. Little D, Brown SA, Campbell NB, et al. Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum. Am J Vet Res 2007; 68: 614-624.
  11. Soylu SM, Şireli M. Farelerde Fluniksin-Megluminin hematolojik parametreler üzerine etkisi. Veteriner Hekimler Derneği Dergisi 2007; 78: 53-56.
  12. Zhang SZ, Noordin MM, Rahman SOA, Haron MJ. Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats. Vet Hum Toxicol 2000; 42: 261-264.
  13. Liu JY, Yang X, Sun XD, et al. Suppressive effects of copper sulfate accumulation on the spermatogenesis of rats. Biol Trace Elem Res 2016; 174: 356-361.
  14. Konyalioglu S, Er A, Uney K, Elmas M, et al. Effect of flunixin meglumin on the antioxidant status in endotoxemia. Acta Veterinaria (Beograd) 2007; 57: 241-