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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2018 / Cilt: 65 - Sayı: 4

The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats

Ratlarda bakır fazlalığına karşı yem tüketimi, antioksidan durum ve karaciğer ile böbrek dokularının histolojik parametreleri üzerine propolis ve fluniksin meglümin'in koruyucu etkileri

Tuba PARLAK AK
Burcu GÜL BAYKALIR
Neşe BAŞAK
Pınar TATLI SEVEN
Mine YAMAN
İsmail SEVEN
Pages
395–406
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P

📌 3 Key Takeaways

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Objective & Hypothesis:This experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper.
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Key Findings & Data:Animals were randomly divided into six groups; control, copper sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip) and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage).
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Conclusion & Impact:The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper. In this study individually housed thirty-six male Sprague-Dawley rats were used. Animals were randomly divided into six groups; control, copper sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip) and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage). The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P

Özet

Bu araştırma, aşırı bakıra maruz bırakılmış sıçanlarda propolis ve fluniksin meglümin’in, yem tüketimi, antioksidan durum ile karaciğer ve böbrek dokularındaki histolojik parametreler üzerindeki koruyucu etkilerini belirlemek amacıyla yapıldı. Araştırmada bireysel olarak barındırılan 36 adet erkek Sprague-Dawley sıçan kullanıldı. Hayvanlar rastgele; kontrol, bakır sülfat (500 mg/kg BW/gün, gavaj), fluniksin meglümin (2,2 mg/kg BW/gün, ip), propolis (100 mg/kg BW/gün, gavaj), bakır sülfat+fluniksin meglümin (500 mg/kg BW/gün bakır sülfat, gavaj ve 2,2 mg/kg BW/gün fluniksin meglümin, ip) ve bakır sülfat+propolis (500 mg/kg BW/gün bakır sülfat ve 100 mg/kg BW/gün propolis, gavaj) olarak altı gruba ayrıldı. Çalışma, bakır+propolis grubunun vücut ağırlığındaki değişimin bakır grubu ile karşılaştırıldığında önemli ölçüde iyileştiğini göstermiştir (P

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Cite This Article

AK, T. P., BAYKALIR, B. G., BAŞAK, N., SEVEN, P. T., YAMAN, M., SEVEN, İ. (2022). The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 65 - Sayı: 4, 395–406. https://ajindex.com/articles/444594

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