SavedAdd your journal

Journals / Cumhuriyet Üniv. Tıp Fak. Derg. / 2003 / Cilt: 25 - Sayı: 3

Correlation between serum leptin levels and calculated basal metabolic rates, insulin and body mass index in the patients with type 2 diabetes mellitus

Tip 2 diabetes mellitus'lu hastalarda serum leptin seviyeleri ile bazal metabolizma hızı, insülin ve vücut kitle indeksi arasındaki ilişki

Ferhan CANDAN
Ercan ÖZDEMİR
Sena ERDAL
Taner ERSELCAN
Sefa GÜLTÜRK
Ümit ÖZDEMİR
Pages
117–122
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There were 32 female, 17 male patients who were taking oral antidiabetic drug (OAİ) in the first group, the second group consisted of 25 female, 19 male patients, taking injectable insülin. in the same time 21 female, 23 male individuals were studied as a control group. it was found that there was a strong correlation between serum levels of leptin and BMR in healthy subjects, however, this was diminished in diabetic patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Leptin released from adipose tissue is thought to have important role in regulating body mass and the energy metabolism.
📊
Key Findings & Data:Serum leptin level increases in obese subjects.
💡
Conclusion & Impact:There were 32 female, 17 male patients who were taking oral antidiabetic drug (OAİ) in the first group, the second group consisted of 25 female, 19 male patients, taking injectable insülin. in the same time 21 female, 23 male individuals were studied as a control group. it was found that there was a strong correlation between serum levels of leptin and BMR in healthy subjects, however, this was diminished in diabetic patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Leptin released from adipose tissue is thought to have important role in regulating body mass and the energy metabolism. Serum leptin level increases in obese subjects. However, it is not exactly known whether there is a relationship between leptin and DM. in the present study we aimed to investigate the correlation between leptin and calculated basal metabolic rate (BMR), insülin and body mass index (BMİ) in type 2 diabetic patients. A total of 137 individuals, between 40 and 60 of ages, were included in the present study. There were 32 female, 17 male patients who were taking oral antidiabetic drug (OAİ) in the first group, the second group consisted of 25 female, 19 male patients, taking injectable insülin. in the same time 21 female, 23 male individuals were studied as a control group. it was found that there was a strong correlation between serum levels of leptin and BMR in healthy subjects, however, this was diminished in diabetic patients. Serum leptin levels of the females was found to be higher than males (p

Özet

Yağ dokusundan salınan leptin hormonunun vücut ağırlığı ve enerji dengesinin sağlanmasında önemli rolü olduğu düşünülmektedir. Obezlerde serum leptin düzeyleri yüksektir. Ancak obeziteye eşlik eden Diabetes Mellitus (DM) gibi hastalıkların leptin ile olan ilişkisi tam olarak bilinmemektedir. Araştırmamızda tip 2 DM'lu hastalarda leptin ile hesaplanan bazal metabolizma hızı (BMR), insülin ve vücut kitle indeksi (VKİ) arasındaki ilişkinin saptanması amaçlanmıştır. Çalışmamıza yaşları 40-60 arasından olan toplam 137 kişi dahil edildi. Birinci grupta kombine oral anti-diabetik ilaç (OAİ) kullanan 32 kadın, 17 erkek, ikinci grupta insülin kullanan 25 kadın, 19 erkek ve kontrol grubu (grup 3) 21 kadın, 23 erkek'ten oluşmaktadır. Sağlıklı kişilerdeki serum leptin seviyesi ile BMR arasındaki korelasyon katsayısının diabetik hastalarda azaldığı görülmüştür. Kadınlardaki serum leptin düzeyleri erkeklere göre belirgin olarak yüksek bulunurken (p

🔖

Cite This Article

CANDAN, F., ÖZDEMİR, E., ERDAL, S., ERSELCAN, T., GÜLTÜRK, S., ÖZDEMİR, Ü. (2022). Correlation between serum leptin levels and calculated basal metabolic rates, insulin and body mass index in the patients with type 2 diabetes mellitus. Cumhuriyet Üniv. Tıp Fak. Derg., Cilt: 25 - Sayı: 3, 117–122. https://ajindex.com/articles/480187

References (15)

  1. Murakami T, Yamashita T, Lida M, Kuwajima M, Shima K. A short from of leptin receptor performs signal transduction. Biochem Biophys Res Commun 1997; 231:26-9
  2. Polito A, Fabbri A, Luzzi A, Cuzzolaro M, Censi L, Ciarapica D, et al. Bazal metabolic rate in anorexia nervoza: relation to Body compozsition and leptin concentrations. Am J Clin Nutr 2000; 71:1495-502
  3. Prins JB, O’Rahilly S. Regulation of adipose cell number in man. Clin Sci 1997; 92:3-11
  4. Wilding J, Widdowson P, Williams G. Neurobiology. Br Med Bull 1997; 53:286-306
  5. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunreactiveleptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334:292-5
  6. Seufert J, Kıeffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab 1999; 84:670-6
  7. Dagogo JS, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 1996; 45:695-8
  8. Mantzoros CS, Flier JS, Lesem MD, Brewerton TD, Jimerson DC. Cerebrospinal fluid leptin in anorexia nervosa:correlation with nutritional status and potential role in resistance to weight gain. J Clin Endocrinol Metab 1997; 82:1845-51
  9. Ruige JB, Dekker JM, Blum WF, Stehouwer CD, Nijpels G, Mooy J, et al. Leptin and variables of body adiposity, energy balance and insulin resistance in a population based study. Diabetes Care 1999; 22:1097-104
  10. Schwartz MW, Seeley RJ. Neuroendocrine responses to starvation and weight loss. N Engl J Med 1997; 336: 1802-11
  11. Leroy P, Dessolin S, Villageois P, Moon BC, Friedman JM, Ailhaud G, Dani C. Expression of ob gene in adipose cells. J Biol Chemistry 1996; 271:2365-8
  12. Haffner SM, Miettinen H, Mykkanen L, Karhapaa P, Rainwater, Laakso M. Leptin concentrations and insülin sensitivity in normoglycemic men. Int J Obesity 1997; 21: 393-9
  13. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Hanry R, Mudaliar SR, Olefsky J, Caro JF. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes 2001; 45:699-701
  14. Lönnqvist F, Wennlund A, Arner P. Relationship between circulating leptin and peripheral fat distribution in obese subjects. İnt J Obesity 1997; 21:255-60
  15. Mistry AM, Swick A, Romsos DR. Leptin alters metabo