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Journals / The Ulutas Medical Journal / 2018 / Cilt: 4 - Sayı: 1

Hemolytic Uremic Syndrome: Single Centre Experience

Can HUZMELİ
Hatice TERZİ
Ferhan CANDAN
Meryem TİMUCİN
Ayse SEKER
Mehmet SENCAN
Mansur KAYATAS
Pages
12–18
Publication Date
2018-01-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

End-stage renal failure developed in 3 of our patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Hemolytic uremic syndrome HUS is a clinical syndrome characterized by non-immune microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure.
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Key Findings & Data:Method: Patients who were diagnosed with HUS as clinic and laboratory between August 2012 and October 2017 were included in our nephrology clinic.
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Conclusion & Impact:End-stage renal failure developed in 3 of our patients.
🔬Design:Review & Systematic Survey
📍Scope:2012 Verileri
⚙️Variables:Acute kidney damage · Hemolytic anemia · thrombocytopenia

Abstract

Introduction: Hemolytic uremic syndrome HUS is a clinical syndrome characterized by non-immune microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. In this study, we aimed to evaluate patients diagnosed with HUS in our clinic. Method: Patients who were diagnosed with HUS as clinic and laboratory between August 2012 and October 2017 were included in our nephrology clinic. Biochemistry, haemogram, ANA, anti-Ds DNA, p-ANCA, c-ANCA, anti-GBM antibody, C3, C4 of patients were studied. In some cases, ADAMTS13 was studied and renal biopsy was performed. The demographic features, clinics, and treatments of our cases were reviewed. Results: A total of 18 patients were enrolled in the study, the average age of the patients was 48.3 21-82 and 10 of the cases were female and 8 of the cases were male. Among the etiologic causes of HUS in patients; the complement factor B mutation, complement factor H polymorphism, breast cancer, herbal medicine, infections and idiopathic were detected. Primer glomerulonephritis was detected in 6 cases of renal biopsy. Conclusion: Clinical and laboratory remission was obtained in 13 patients. End-stage renal failure developed in 3 of our patients.

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Cite This Article

HUZMELİ, C., TERZİ, H., CANDAN, F., TİMUCİN, M., SEKER, A., SENCAN, M., KAYATAS, M. (2018). Hemolytic Uremic Syndrome: Single Centre Experience. The Ulutas Medical Journal, Cilt: 4 - Sayı: 1, 12–18. https://ajindex.com/articles/844463

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References (17)

  1. Amirlak I, Amirlak B. Haemolytic uraemic syndrome: An overview. Nephrology 2006;11:213–218
  2. Canpolat N. Hemolytic uremic syndrome. Turk Pediatri Ars. 2015; 50: 73-82
  3. Noris M, Remuzzi G. Hemolytic uremic syndrome. J Am Soc Nephrol. 2005; 16: 1035–1050
  4. Blaser MJ. Deconstructing a lethal food borne epidemic. N Engl J Med. 2011; 365: 1835-1836
  5. Salvadori M, Bertoni E. Update on haemolytic uremic syndrome: Diagnostic and therapeutic recommendations. World J Nephrol 2013; 2(3): 56-76
  6. Sharma AP, Greenberg CR, Prasad AN, Prasad C. Hemolytic uremic syndrome (HUS) secondary to cobalamin C (cblC) disorder. Pediatr Nephrol 2007;22:2097-2103
  7. Waters AM, Kerecuk L, Luk D, Haq MR, Fitzpatrick MM, Gilbert RD, et al. Hemolytic uremic syndrome associated with invasive pneumococcal disease: the United kingdom experience. J Pediatr. 2007;151:140-144
  8. Allen U, Licht C. Pandemic H1N1 influenza A infectionand (atypical) HUS more than just another trigger? Pediatr Nephrol. 2011;26:3-5
  9. Besbas N, Karpman D, Landau D, Loirat C, Proesmans W, Remuzzi G, et al. A classification of haemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders. Kidney Int. 2006;70(3):423-431
  10. Frank C, Werber D, Cramer JP, Askar M, Faber M, an der Heiden M, et al. Epidemic profile of Shiga-toxin- producing Escherichia coli O104:H4 outbreak in Germany. N Engl J Med. 2011;365: 1771-1780
  11. Srivastava RN, Moudgil A, Bagga A, Vasudev AS. Hemolytic uremic syndrome in children in northern India. Pediatr Nephrol. 1991;3:284-288
  12. Noris M, Remuzzi G. “Genetic abnormalities of complement regulators in haemolytic uremic syndrome: how do they affect patient management?” Nature Clinical Practice Nephrology. 2005;1:2–3
  13. Kavanagh D and Goodship T. “Genetics and complement in atypical HUS,” Pediatric Nephrology. 2010;25:2431–2442
  14. Botto M, Kirschfink M, Macor P, Pickering MC, Würzner R, Tedesco F. Complement in human disease: Lessons from complement deficiencies. Mol Immunol. 2009;46:2774-2783
  15. Pettigrew HD, Teuber SS, Gershwin ME. Clinical significance of complement deficiencies. Ann N Y Acad Sci. 2009;1173: 108-123
  16. Noris M, Caprioli J, Bresin E, Mossali C, Pianetti G, Gamba S, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol. 2010;5:1844-1859
  17. Chang A, Kowalewska J, Smith KD, Nicosia RF, Alpers CE. A clinicopathologic study of thromb