SavedAdd your journal

Journals / Anadolu Kardiyoloji Dergisi / 2011 / Cilt: 11 - Sayı: 1

Low L-carnitine levels: Can it be a cause of nocturnal blood pressure changes in patients with type 2 diabetes mellitus?

Düşük L-karnitin düzeyleri: Tip 2 diyabetes mellitus olgularında noktürnal kan basıncı değişikliklerinin bir nedeni olabilir mi?

Ferhan CANDAN
Serdal KORKMAZ
Hüseyin AYDIN
Serhat İÇAĞASIOĞLU
Abdulkerim YILMAZ
Fatih KILIÇLI
Gürsel YILDIZ
Pages
57–63
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

L-carnitine levels were lower in patients with type 2 DM (52.77±12.34 μmol/L) than those of control group (79.18±10.59 μmol/L), and these differences were statistically significant (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The nocturnal blood pressure (NBP) reduction is less than normal in the patients with type 2 diabetes mellitus (type 2 DM).
📊
Key Findings & Data:L-carnitine deficiency may cause changes of NBP by leading to hyperglycemia, insulin resistance and endothelial dysfunction in patients with type-2 DM.
💡
Conclusion & Impact:L-carnitine levels were lower in patients with type 2 DM (52.77±12.34 μmol/L) than those of control group (79.18±10.59 μmol/L), and these differences were statistically significant (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The nocturnal blood pressure (NBP) reduction is less than normal in the patients with type 2 diabetes mellitus (type 2 DM). L-carnitine deficiency may cause changes of NBP by leading to hyperglycemia, insulin resistance and endothelial dysfunction in patients with type-2 DM. The purpose of the study was to investigate whether there is a difference in levels of L-carnitine in dipper and nondippers patients with type 2 DM. Methods: This is a cross-sectional observational cohort study. We compared the 50 (33 females, 17 males) patients with type 2 DM and the 35 healthy persons (18 females, 17 males) as a control group. In all cases, ambulatory blood pressure monitoring (ABPM) was performed and L-carnitine was measured. The independent samples t test, Chi-square test, Mann-Whitney U test and Pearson correlation analysis were used in the statistical evaluation of data. Results: We found that the percentage of nondipper pattern was 72% in patients with type 2 DM. L-carnitine levels were lower in patients with type 2 DM (52.77±12.34 μmol/L) than those of control group (79.18±10.59 μmol/L), and these differences were statistically significant (p

Özet

Tip 2 diyabetes mellituslu (tip 2 DM) hastalarda noktürnal kan basıncındaki (NKB) düşüş normalden daha azdır. L-karnitin eksikliği tip 2 DM olgularında hiperglisemi, insülin direnci ve endotel disfonksiyonuna yol açarak NKB değişikliklerine neden olabilmektedir. Bu çalışmada; tip 2 DM’li “dipper” ve “non-dipper” olgularda L-karnitin düzeyinde farklılık olup olmadığının araştırılması amaçlanmıştır. Yöntemler: Bu bir enine-kesitli gözlemsel kohort çalışmasıdır. Çalışmada tip 2 DM’li 50 (33 kadın, 17 erkek) olguyu ve kontrol grubu olarak sağlıklı 35 (18 kadın, 17 erkek) kişiyi karşılaştırdık. Tüm olgularda ambulatuvar kan basıncı izlemi (ABPM) yapıldı ve L-karnitin ölçüldü. Verilerin değerlendirilmesinde iki ortalama arasındaki farkın önemlilik testi, Ki-kare testi, Mann-Whitney U testi ve Pearson korelasyon analizi kullanıldı. Bulgular: Tip 2 DM’lerin %72'sinde “non-dipper” örnek saptadık. Tip 2 DM’lerde L-karnitin düzeyi (52.77±12.34 µmol/L) kontrol grubuna göre (79.18±10.59 µmol/L) istatistiksel olarak anlamlı derecede düşük saptandı (p

🔖

Cite This Article

CANDAN, F., KORKMAZ, S., AYDIN, H., İÇAĞASIOĞLU, S., YILMAZ, A., KILIÇLI, F., YILDIZ, G. (2022). Low L-carnitine levels: Can it be a cause of nocturnal blood pressure changes in patients with type 2 diabetes mellitus?. Anadolu Kardiyoloji Dergisi, Cilt: 11 - Sayı: 1, 57–63. https://ajindex.com/articles/436605

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Mancia G, Parati G, Di Rienzo M, Zanchetti A. Blood pressure variability. In: Zanchetti A, Mancia G, editors. Pathophysiology of Hypertension (Handbook of Hypertension Vol.17). Elsevier Science 1997. p. 117-69
  2. O'Brien E, Sheridan J, O'Malley K. Dippers and non-dippers. Lancet 1988; 13: 397
  3. Verdecchia P, Schillaci G, Borgioni C, Ciucci A. White coat hypertension: not guilty when correctly defined. Blood Pres Monit 1998; 3: 147-52
  4. Kario K, Matsuo T, Kobayashi H, Imiya M, Matsuo M, Shimada K. Nocturnal fall of blood pressure and silent cerebrovascular damage in elderly hypertensive patients. Advanced silent cerebrovascular damage in extreme dippers. Hypertension 1996; 27: 130-5
  5. Pickering TG, Kario K. Nocturnal non-dipping: what does it augur? Curr Opin Nephrol Hypertens 2001; 10: 611-6
  6. Atasoyu ME, Ünver S, Cingözbay Y, Evrenkaya TR, Tülbek MY. Genç normotansif ve hipertansif bireylerde ayaktan kan basıncı izlemi sonuçları. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 2001; 10: 115-22
  7. Soylu A, Güleç H, Alihanoğlu YI, Sönmez O, Ayhan SS, Gök H. Metabolik sendromlu hastalarda nondipper kan basıncı seyrinin hedef organ hasarı üzerine etkisi. Türk Kardiyol Dern Arş 2009; 37: 454-60
  8. Cusaro C, Zamboni G, Chiarinotti D, Cadario F, Allochis G, Fortina A, et al. 24 Hour arterial pressure in insulin-dependent diabetics and non-insulin-dependent diabetics with preserved renal function. Minerva Urol Nefrol 1999; 51: 143-8
  9. DiPalma JR. Carnitine deficiency. Am Fam Physician 1998; 38: 243-51
  10. Kendler BS. Carnitine: an overview of its role in preventive medicine. Prev Med 1986; 15: 373-90
  11. Tamamoğulları N, Siliğ Y, İçağasıoğlu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. J Diabetes Complications 1999; 13: 251-3
  12. Mingrone G, Greco AV, Capristo E, Benedetti G, Giancaterini A, De Gaetano A, et al. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Coll Nutr 1999; 18: 77-82
  13. Peluso G, Petillo 0, Margarucci S, Mingrone G, Greco AV, Indiveri C, et al. Decreased mitochondrial carnitine translocase in skeletal muscles impairs utilization of fatty acids in insulin- resistant patients. Front Biosci 2002; 7: 109-16
  14. Okuda Y, Kawai K, Murayama Y, Yamashita K. Postprandial changes in plasma ketone body and carnitine levels in normal and non-insulin dependant diabetic subjects. Endocrinol Japan 1987; 34: 415-22
  15. Winter SC, Simon M, Zorn EM, Szabo-Aczel S, Vance WH, O'Hara T, et al.