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Journals / Arşiv Kaynak Tarama Dergisi / 2011 / Cilt: 20 - Sayı: 3

Killer Cell Immunoglobulin-Like Receptor Genes

Doğal Öldürücü Hücre Immunglobulin-Benzeri Reseptör Genleri

Özlem Görüroğlu ÖZTÜRK
Pages
131–144
Publication Date
2011-09-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review discussed the biology and genetics of KIR molecules which are important in many diseases and transplantation immunology.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Killer cell immunoglobulin-like receptors (KIRs) are the molecules expressed on the surface of the natural killer (NK) cells and play an important role in innate immunity.
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Key Findings & Data:KIRs are encoded by a gene cluster at human chromosome 19q13.4.
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Conclusion & Impact:This review discussed the biology and genetics of KIR molecules which are important in many diseases and transplantation immunology.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Doğal immunite · HLA · KIR

Abstract

Killer cell immunoglobulin-like receptors (KIRs) are the molecules expressed on the surface of the natural killer (NK) cells and play an important role in innate immunity. KIRs are encoded by a gene cluster at human chromosome 19q13.4. The KIR gene cluster is highly polymorphic, with individual genes exhibiting allelic variability and individual haplotypes differing in gene content. The polymorphism of the KIR locus parallels that of the HLA, facilitating the adaptation of the immune system to a dynamic, challenging environment. This variation is associated with a growing number of human diseases. This review discussed the biology and genetics of KIR molecules which are important in many diseases and transplantation immunology.

Özet

Doğal öldürücü hücre immünglobulin-benzeri reseptörler (Killer cell immunoglobulin-like receptors, KIR), doğal öldürücü hücrelerin yüzeylerinde eksprese olan ve doğal immünitenin düzenlenmesinde önemli rol oynayan moleküllerdir. KIR’lar 19q13.4 kromozomundaki bir gen demeti tarafından kodlanmaktadır. KIR gen demeti oldukça polimorfiktir, bireysel genler allelik polimorfizm içerirken, bireysel haplotipler gen içeriyi açısından farklılıklar gösterir. Human Lökosit Antijen (HLA) genlerine paralel olan KIR lokusunun polimorfizmleri, immün sistemin dinamik ve gelişen çevreye adaptasyonunu kolaylaştırmaktadır. Bu varyasyon pek çok hastalıkla ilişkilidir. Bu derlemede pek çok hastalıkta ve transplantasyon immünolojisinde önem taşıyan KIR moleküllerinin, biyolojisi ve genetiği konuları ele alınmıştır.

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Cite This Article

ÖZTÜRK, Ö. G. (2011). Killer Cell Immunoglobulin-Like Receptor Genes. Arşiv Kaynak Tarama Dergisi, Cilt: 20 - Sayı: 3, 131–144. https://ajindex.com/articles/466232

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