Journals / Cukurova Medical Journal / 2022 / Cilt: 47 - Sayı: 3

Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia

Hiponatremili hastalarda serum nöron spesifik enolaz düzeyleri ile beyin hasarı arasındaki ilişki

Pages
1147–1153
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Of the patients in group 2 (n = 45), 8 patients with loss of consciousness (low Glasgow Coma Scale scores) (i.e.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: In this study, we aimed to investigate the effects of serum neuron specific enolase on the prediction of central nervous system injury and the clinical course in patients to have hyponatremia.
📊
Key Findings & Data:Materials and Methods: 75 adult patients with serum sodium levels less than 135 mEq/L were evaluated.
💡
Conclusion & Impact:Of the patients in group 2 (n = 45), 8 patients with loss of consciousness (low Glasgow Coma Scale scores) (i.e.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: In this study, we aimed to investigate the effects of serum neuron specific enolase on the prediction of central nervous system injury and the clinical course in patients to have hyponatremia. Materials and Methods: 75 adult patients with serum sodium levels less than 135 mEq/L were evaluated. The patients were grouped according to serum neuron specific enolase levels (group 1 ≤ 17.0 ng/mL and group 2 > 17.0 ng/mL). The groups were compared according to demographic and laboratory data. Results: The incidence of hypertension, heart failure, and loss of consciousness was significantly higher in group 2 patient. High neuron specific enolase levels were related to lower serum sodium levels. The mean sodium levels were 129.5 ± 4.3 mEq/L and 126 ± 4.5 mEq/L in groups 1 and 2, respectively. Of the patients in group 2 (n = 45), 8 patients with loss of consciousness (low Glasgow Coma Scale scores) (i.e.

Özet

Amaç: Bu çalışmada hiponatremili hastalarda serum nöron spesifik enolazın santral sinir sistemi hasarını öngörmesi ve klinik gidiş üzerindeki etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Bu prospektif çalışmada, serum sodyum seviyeleri 135 mEq/L'nin altında olan 75 yetişkin hasta değerlendirildi. Hastalar serum nöron spesifik enolaz düzeylerine göre gruplandırıldı (grup 1 ≤ 17.0 ng/mL ve grup 2 > 17.0 ng/mL). Gruplar demografik ve laboratuvar verilerine göre karşılaştırıldı. Bulgular: Grup 2 hastalarında hipertansiyon, kalp yetmezliği ve bilinç kaybı insidansı anlamlı olarak daha yüksekti. Yüksek nöron spesifik enolaz seviyeleri, daha düşük serum sodyum seviyeleri ile ilişkiliydi. Ortalama sodyum seviyeleri grup 1 ve 2'de sırasıyla 129.5 ± 4.3 mEq/L ve 126 ± 4.5 mEq/L idi. Grup 2'deki hastalardan (n = 45), bilinç kaybı olan (düşük Glasgow Koma Skalası skorları) (GKS

🔖

Cite This Article

MATYAR, S., AKPINAR, A. A., DİŞEL, N. R., ÖZTÜRK, Ö. G., DAĞLIOĞLU, G., AKPINAR, O. (2022). Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. Cukurova Medical Journal, Cilt: 47 - Sayı: 3, 1147–1153. https://ajindex.com/articles/476813

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D et al. Hyponatraemia guideline development group. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Nephrol Dial Transplant. 2014;29:i1-39
  2. Gankam Kengne F, Decaux G. Hyponatremia and the brain. Kidney Int Rep. 2018;3:24–35
  3. Nardone R, Brigo F, Trinka E. Acute symptomatic seizures caused by electrolyte disturbances. J Clin Neurol. 2016;12:21-33
  4. Grant P, Ayuk J, Bouloux PM, Cohen M, Cranston I, Murray R et al. The diagnosis and management of inpatient hyponatraemia and SIADH. Eur J Clin Invest. 2015;45:888-94
  5. Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med. 2006;119:71.e1-8
  6. Dineen R, Thompson CJ, Sherlock M. Hyponatraemia – presentations and management. Clin Med. 2017;17:263-9
  7. Yuan SM. Biomarkers of cerebral injury in cardiac surgery. Anatol J Cardiol. 2014;14:638-45
  8. Tolan NV, Vidal-Folch N, Algeciras-Schimnich A, Singh RJ, Grebe SK. Individualized correction of neuron-specific enolase (NSE) measurement in hemolyzed serum samples. Clin Chim Acta. 2013;23:216-21
  9. Mercier E, Boutin A, Shemilt M, Lauzier F, Zarychanski R, Fergusson D et al. Predictive value of neuron-specific enolase for prognosis in patients with moderate or severe traumatic brain injury: a systematic review and meta-analysis. CMAJ. 2016;4:371-82
  10. Cheng F, Yuan Q, Yang J, Wang W, Liu H. The prognostic value of serum neuron-specific enolase in traumatic brain injury: systematic review and meta- analysis. PLoS One. 2014;4:e106680
  11. Stammet P, Collignon O, Hassager C, Wise MP, Hovdenes J, Åneman A et al. Neuron-specific enolase as a predictor of death or poor neurological outcome after out-of-hospital cardiac arrest and targeted temperature management at 33°C and 36°C. J Am Coll Cardiol. 2015;65:2104-14
  12. Kim BJ, Kim YJ, Ahn SH, Kim NY, Kang DW et al. The second elevation of neuron-specific enolase peak after ischemic stroke is associated with hemorrhagic transformation. J Stroke Cerebrovasc Dis. 2014;23:2437-43
  13. Bharosay A, Bharosay VV, Varma M, Saxena K, Sodani A, Saxena R. Correlation of brain biomarker neuron specific enolase (NSE) with degree of disability and neurological worsening in cerebrovascular stroke. Indian J Clin Biochem. 2012;27:186-90
  14. Liu Q, Fan J, Xu A, Yao L, Li Y, Wang et al. Distribution of serum neuron-specific enolase and the estab