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Journals / Arşiv Kaynak Tarama Dergisi / 2015 / Cilt: 24 - Sayı: 3

Pancreas-Bone-Testis Axis

Pankreas-Kemik-Testis Ekseni

Gülfidan COŞKUN
Hülya ÖZGÜR
Sait POLAT
Pages
355–367
Publication Date
2015-09-14
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, a newly defined pathwaycalled pancreas-bone-testis axis which stimulates testosterone synthesis independent of hypothalamic hypophyseal testicular axis, is discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Bone which has movement and support functions, is the largest organ of the body.
📊
Key Findings & Data:Bone is regulated by hormonal signal but it also acts as an endocrine organ.
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Conclusion & Impact:In this review, a newly defined pathwaycalled pancreas-bone-testis axis which stimulates testosterone synthesis independent of hypothalamic hypophyseal testicular axis, is discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Pankreas · kemik · testis

Abstract

Bone which has movement and support functions, is the largest organ of the body. Bone is regulated by hormonal signal but it also acts as an endocrine organ. Many peptide hormones such asosteocalcin are secreted from bone. Osteocalcin which is an osteoblast derived hormone, has two forms: “carboxylated (inactive) osteocalcin and decarboxylated (active) osteocalcin”. While inactive osteocalcin is found in bone matrix, active osteocalcin is given to blood circulation and acts as a multifunctional hormone. In the past ten years, numerous epidemiological, genetic and biochemical studies have revealed hormonal links between bone and pancreas, adipose tissue, gonads via active osteocalcin. In this review, a newly defined pathwaycalled pancreas-bone-testis axis which stimulates testosterone synthesis independent of hypothalamic hypophyseal testicular axis, is discussed.

Özet

Kemik; hareket ve destek fonksiyonuna sahip vücudun en büyük organıdır. Hormonal uyarılarla regüle olan kemik dokunun, kendisi de endokrin bir organ olarak davranır. Osteokalsin başta olmak üzere pek çok peptid yapıda hormon salgılar. Osteoblastlarda sentezlenen osteokalsin’in: “karboksile (inaktif) osteokalsin ve dekarboksile (aktif) osteokalsin” olmak üzere 2 formu bulunmaktadır. İnaktif osteokalsin, kemik matriksinde bulunurken aktif osteokalsin kan dolaşımına verilir ve multifonksiyonel hormon olarak davranır. Aktif osteokalsin; enerji metabolizması ve erkek fertilitesini regüle eder. Geçtiğimiz on yılda sayısız epidemiyolojik, genetik ve biyokimyasal çalışmada, kemik dokunun aktif osteokalsin aracılığıyla pankreas, adipoz doku ve gonadlar ile arasındaki hormonal bağlantıları gösterilmiştir. Bu makalede hipotalamohipofizyal testis ekseninden bağımsız olarak testosteron sentezini uyaran yeni tanımlanmış pankreas-kemik-testis ekseninin mekanizması tartışılmıştır.

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Cite This Article

COŞKUN, G., ÖZGÜR, H., POLAT, S. (2015). Pancreas-Bone-Testis Axis. Arşiv Kaynak Tarama Dergisi, Cilt: 24 - Sayı: 3, 355–367. https://ajindex.com/articles/466059

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