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Journals / Atatürk Üniversitesi Veteriner Bilimleri Dergisi / 2007 / Cilt: 2 - Sayı: 3

Protective effect of Panax ginseng against Carbon tetrachloride ($CCl _4 $) - induced oxidative brain injury in rats

Sıçanlarda Karbon tetraklorürün ($CCl _4 $) neden olduğu oksidatif beyin hasarına karşı Panax ginseng’ in koruyucu etkisi

Fikret ÇELEBİ
Ali KARADENİZ
Abdulkadir YILDIRIM
Pages
117–121
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Panax ginseng showed a significantbrain-protective effect by decreasing the level of lipid peroxidation (MDA) and elevated the activities of GSH and SOD (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study was designed to investigate the protective effects of Panax ginseng against acute brain damage induced by $CCl _4$ in rats.
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Key Findings & Data:A total of 30 healthy femaleSprague–Dawley rats were divided in to three groups.
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Conclusion & Impact:Panax ginseng showed a significantbrain-protective effect by decreasing the level of lipid peroxidation (MDA) and elevated the activities of GSH and SOD (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study was designed to investigate the protective effects of Panax ginseng against acute brain damage induced by $CCl _4$ in rats. A total of 30 healthy femaleSprague–Dawley rats were divided in to three groups. Sedentary control group (group C) injected intraperitoneally (i.p.) with physiological saline as placebo for 7 consecutive days. $CCl _4$ toxication group was injected by i.p. a single dose of $CCl _4$ (group $CCl _4$). Panax ginseng plus $CCl _4$ group (200 mg/kg) was feeding through an orogastric tube for 7 consecutive days prior to $CCl _4$ injection (group $CCl _4$ + PG). The degree of protection in brain tissue was evaluated by the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and nitric oxide (NO). Panax ginseng showed a significantbrain-protective effect by decreasing the level of lipid peroxidation (MDA) and elevated the activities of GSH and SOD (p

Özet

Bu çalışma $CCl _4$ ile beyin hasarı oluşturulmuş sıçanlarda Panax ginseng’ in koruyucu etkilerini incelemek için yapılmıştır. Toplam 30 adet dişi Sprague – Dawley sıçan üç eşit gruba ayrıldı. Kontrol grubuna placebo olarak 7 gün boyunca intraperitoneal (i.p.) serum fizyolojik uygulandı (grup C). $CCl _4$ toksikasyon grubuna ise i.p. tek doz $CCl _4$ uygulandı (grup $CCl _4$). Panax ginseng + $CCl _4$ grubuna ise i.p. $CCl _4$ uygulamasından önce 7 gün boyunca orogastrik tüp aracılığıyla Panax ginseng (200 mg/kg) verildi (grup $CCl _4$ + PG). Beyin dokusundaki korumanın derecesi malondialdehit (MDA), glutathion (GSH), superoksit dismutaz (SOD), glutatyon peroksidaz (GPx) ve nitrik oksit (NO) düzeyleri ölçülerek belirlendi. Panax ginseng lipit peroksidasyon (MDA) düzeyini azaltırken, GSH ve SOD (p

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Cite This Article

ÇELEBİ, F., KARADENİZ, A., YILDIRIM, A. (2022). Protective effect of Panax ginseng against Carbon tetrachloride ($CCl _4 $) - induced oxidative brain injury in rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, Cilt: 2 - Sayı: 3, 117–121. https://ajindex.com/articles/456152

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