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Journals / Adıyaman Üniversitesi Fen Bilimleri Dergisi / 2021 / Cilt: 11 - Sayı: 1

Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A

Ahmet ÖZKAYA
Zafer ŞAHİN
Yunus ŞAHİN
Özgür BULMUŞ
Miraç UÇKUN
Ertan YOLOĞLU
Pages
73–86
Publication Date
2021-06-30
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Our results showed BPA suppresses testicular detoxification activity and increases lipid peroxidation in rats.

📌 3 Key Takeaways

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Objective & Hypothesis:We aimed to evaluate the effects of black carrot extract on testicular carboxylesterase (Ces) activity, malondialdehyde (MDA), glutathione S-transferases (GST) and reduced glutathione (GSH) in male rats exposed to bisphenol A (BPA).
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Key Findings & Data:Adult Wistar albino male rats were divided into 4 groups as follows (n = 7/group): control, BPA, black carrot and BPA+Black carrot.
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Conclusion & Impact:Our results showed BPA suppresses testicular detoxification activity and increases lipid peroxidation in rats.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Bisphenol A · Black carrot · Testis

Abstract

We aimed to evaluate the effects of black carrot extract on testicular carboxylesterase (Ces) activity, malondialdehyde (MDA), glutathione S-transferases (GST) and reduced glutathione (GSH) in male rats exposed to bisphenol A (BPA). Adult Wistar albino male rats were divided into 4 groups as follows (n = 7/group): control, BPA, black carrot and BPA+Black carrot. Testicular Ces, MDA, GST and reduced GSH were analyzed by using a spectrophotometer system. Testicular Ces activity was significantly lower only in the BPA group than the control group (p < 0.001). Testicular MDA concentrations were higher only in the BPA group compared with the control group (p < 0.001). Reduced GSH level was higher in the black carrot and BPA+Black carrot groups than the control group (p < 0.05). GST activity was lower in the BPA group in comparison to the control group (p < 0.05). In the black carrot and BPA+Black carrot groups, the GST activities were higher than the control group (p < 0.001). Our results showed BPA suppresses testicular detoxification activity and increases lipid peroxidation in rats. We observed that black carrot extract has a beneficial effect on the toxic and oxidative stress-related parameters caused by BPA exposure.

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Cite This Article

ÖZKAYA, A., ŞAHİN, Z., ŞAHİN, Y., BULMUŞ, Ö., UÇKUN, M., YOLOĞLU, E. (2021). Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A. Adıyaman Üniversitesi Fen Bilimleri Dergisi, Cilt: 11 - Sayı: 1, 73–86. https://ajindex.com/articles/451019

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References (12)

  1. Pistrick, K., Mansfeld’s Encyclopedia of Agricultural and Horticultural Crops. 1st ed, 2001
  2. Erten, H., Tanguler, H., Canbaş, A., A traditional Turkish lactic acid fermented beverage: shalgam (salgam), Food Reviews International, 24(3), 352–359, 2008
  3. Montilla, E.C., Arzaba, M.R., Hillebrand, S. et al., Anthocyanin composition of black carrot (daucus carota ssp sativus var atrorubens alef) cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze, Journal of Agricultural and Food Chemistry, 59(7), 3385–3390, 2011
  4. Kırca, A., Özkan, M., Cemeroglu, B., Stability of black carrot anthocyanins in various fruit juices and nectars, Food Chemistry, 97(4), 598–605, 2006
  5. Kaur, A., Singh Sogi, D., Influence of development stages on the physicochemical properties of black carrots (Daucus carota L), Cogent Food & Agriculture, 6(1), 1841358, 2020
  6. Yildiz, E., Guldas, M., Gurbuz, O., Determination of in-vitro phenolics, antioxidant capacity and bio-accessibility of Kombucha tea produced from black carrot varieties grown in Turkey, Food Science and Technology, 2020
  7. Nouri, M., Khaki, A., Azar, F.F. et al., The protective effects of carrot seed extract on spermatogenesis and cauda epididymal sperm reserves in gentamicin treated rats, Yakhteh, 11(3), 327–333, 2009
  8. Yakubu, M.T., Opakunle, F.K., Salimon, S.S., Effects of the ethanolic extract of Daucus carota L seeds on acetaminophen-induced uremia and antiandrogenicity in male rats, Tropical Journal of Health Sciences, 24(3), 33–40, 2017
  9. Goodson, A., Robin, H., Summerfield, W. et al., Migration of bisphenol A from can coatings—effects of damage, storage conditions and heating, Food Additives and Contaminants, 21(10), 1015–1026, 2004
  10. Geens, T., Aerts, D., Berthot, C. et al., A review of dietary and non-dietary exposure to bisphenol-A, Food and Chemical Toxicology, 50(10), 3725–3740, 2012. [11] vom Saal, F.S., Akingbemi, B.T., Belcher, S.M. et al., Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure, Reproductive Toxicology, 24(2), 131–138, 2007
  11. Cariati, F., D’Uonno, N., Borrillo, F. et al., Bisphenol A: an emerging threat to male fertility, Reproductive Biology and Endocrinology, 17(1), 6, 2019
  12. Manfo, F.P.T., Jubendradass, R., Nantia, E.A. et al., Adverse effects of bisphenol A on male reproductive function, Reviews of environmental contamination and