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Journals / Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / 2026 / Cilt: 10 Sayı: 1

Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity

Sentezlenen bir kumarin türevi olan etil 7-hidroksi-2-imino-2H-kromen-3-karboksilatın'ın Bisfenol A ile indüklenen böbrek toksisitesi üzerine etkileri

Nadir Bilgin Akgül(İNÖNÜ ÜNİVERSİTESİ)0000-0002-6378-3546
Muhammed Mehdi Üremiş(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ)0000-0003-2296-2422
Nuray Üremiş(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ)0000-0002-3958-4352
Ebru Annaç(ADIYAMAN ÜNİVERSİTESİ)0000-0001-9726-5846
Rıfat Cesur Bozat(ADIYAMAN ÜNİVERSİTESİ)0000-0003-1658-3143
Murat Koca(ADIYAMAN ÜNİVERSİTESİ)0000-0002-9250-0293
Ahmet Özkaya(ADIYAMAN ÜNİVERSİTESİ)0000-0002-0173-3084
Elif Merve Betül Yanılmaz(ADIYAMAN ÜNİVERSİTESİ)0000-0001-9613-0149
Pages
1–9
Publication Date
2024-04-23
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate (CM) against the renal toxicity of Bisphenol A (BPA).
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Key Findings & Data:Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate.
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Conclusion & Impact:Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Bisfenol A · Kumarin · Böbrek

Abstract

Aim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate (CM) against the renal toxicity of Bisphenol A (BPA). Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate. Experiment was conducted in four groups of rats: control, BPA, CM, and BPA+CM. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), and Malondialdehyde (MDA) levels in kidney tissue were evaluated. serum samples were analyzed for Total-Native thiol and kidney function test parameters. Results: The BPA-treated group exhibited significant decreases in TAS and thiol levels, increases in TOS and MDA levels. However, these side effects were significantly reduced with CM. Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.

Özet

Amaç: Bu çalışmada sentezlenen kumarin etil 7-hidroksi-2-imino-2H-kromen-3 karboksilatın (CM) Bisfenol A'nın (BPA) renal toksisitesine karşı koruyucu etkinliğinin araştırılması amaçlandı. Gereç ve Yöntem: CM molekülü, 2,4-dihidroksibenzaldehit ve etil siyanoasetat arasındaki reaksiyon yoluyla sentezlendi. Hayvan denemeleri için ratlar dört gruba ayrıldı: kontrol, BPA, CM ve BPA + CM. Böbrek dokusunda Toplam Antioksidan Durum (TAS), Toplam Oksidan Durum (TOS) ve Malondialdehit (MDA) seviyeleri değerlendirildi. Serum örnekleri Total-Native tiyol ve böbrek fonksiyon testi parametreleri açısından analiz edildi. Bulgular: BPA ile tedavi edilen grupta TAS ve tiyol düzeylerinde önemli düşüşler, TOS ve MDA düzeylerinde ise artışlar görüldü. Ancak CM ile bu yan etkiler önemli ölçüde azaldı. Sonuç: Bu çalışmada elde edilen sonuçlar CM molekülünün BPA kaynaklı böbrek toksisitesine karşı koruyucu etkiye sahip olduğunu göstermektedir.

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Cite This Article

Akgül, N. B., Üremiş, M. M., Üremiş, N., Annaç, E., Bozat, R. C., Koca, M., Özkaya, A., Yanılmaz, E. M. B. (2024). Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 10 Sayı: 1, 1–9. https://doi.org/10.30569/adiyamansaglik.1373918

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