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Dergiler / Adıyaman Üniversitesi Fen Bilimleri Dergisi / 2021 / Cilt: 11 - Sayı: 1

Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A

Ahmet ÖZKAYA
Zafer ŞAHİN
Yunus ŞAHİN
Özgür BULMUŞ
Miraç UÇKUN
Ertan YOLOĞLU
Sayfa
73–86
Yayın Tarihi
2021-06-30
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

We observed that black carrot extract has a beneficial effect on the toxic and oxidative stress-related parameters caused by BPA exposure.

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Amaç & Hipotez:We aimed to evaluate the effects of black carrot extract on testicular carboxylesterase (Ces) activity, malondialdehyde (MDA), glutathione S-transferases (GST) and reduced glutathione (GSH) in male rats exposed to bisphenol A (BPA).
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Temel Bulgular & Veri:Adult Wistar albino male rats were divided into 4 groups as follows (n = 7/group): control, BPA, black carrot and BPA+Black carrot.
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Sonuç & Katkı:We observed that black carrot extract has a beneficial effect on the toxic and oxidative stress-related parameters caused by BPA exposure.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Bisphenol A · Black carrot · Testis

Abstract

We aimed to evaluate the effects of black carrot extract on testicular carboxylesterase (Ces) activity, malondialdehyde (MDA), glutathione S-transferases (GST) and reduced glutathione (GSH) in male rats exposed to bisphenol A (BPA). Adult Wistar albino male rats were divided into 4 groups as follows (n = 7/group): control, BPA, black carrot and BPA+Black carrot. Testicular Ces, MDA, GST and reduced GSH were analyzed by using a spectrophotometer system. Testicular Ces activity was significantly lower only in the BPA group than the control group (p < 0.001). Testicular MDA concentrations were higher only in the BPA group compared with the control group (p < 0.001). Reduced GSH level was higher in the black carrot and BPA+Black carrot groups than the control group (p < 0.05). GST activity was lower in the BPA group in comparison to the control group (p < 0.05). In the black carrot and BPA+Black carrot groups, the GST activities were higher than the control group (p < 0.001). Our results showed BPA suppresses testicular detoxification activity and increases lipid peroxidation in rats. We observed that black carrot extract has a beneficial effect on the toxic and oxidative stress-related parameters caused by BPA exposure.

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Bu Makaleye Atıf Yap

ÖZKAYA, A., ŞAHİN, Z., ŞAHİN, Y., BULMUŞ, Ö., UÇKUN, M., YOLOĞLU, E. (2021). Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A. Adıyaman Üniversitesi Fen Bilimleri Dergisi, Cilt: 11 - Sayı: 1, 73–86. https://ajindex.com/articles/451019

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