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Journals / Arşiv Kaynak Tarama Dergisi / 2018 / Cilt: 27 - Sayı: 4

Role of Netrin-1 in Cardiovascular Diseases

Kardiyovasküler Hastalıklarda Netrin-1’in Rolü

Lülüfer Tamer GÜMÜŞ
Nil DOĞRUER ÜNAL
Ayşegül GÖRÜR
Pages
440–458
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of this review is to highlight the diverse and opposite effects and the functions of netrin-1 signalling during the cardiovascular diseases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Netrins which are a family of laminin-like proteins, first described for their role in embryonic axonal guidance.
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Key Findings & Data:Researchers have proven the roles of netrin-1 in the development and formation of non-neural tissue apart from its role in the central nervous system .In cardiovascular area, netrin-1 is involved in angiogenesis, promotes atherosclerosis, protects the heart against ischemia–reperfusion injury, and reduces the infarct size.
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Conclusion & Impact:The aim of this review is to highlight the diverse and opposite effects and the functions of netrin-1 signalling during the cardiovascular diseases.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Netrins which are a family of laminin-like proteins, first described for their role in embryonic axonal guidance. These chemotropic molecules act as a bifunctional regulator of neuron migration. Researchers have proven the roles of netrin-1 in the development and formation of non-neural tissue apart from its role in the central nervous system .In cardiovascular area, netrin-1 is involved in angiogenesis, promotes atherosclerosis, protects the heart against ischemia–reperfusion injury, and reduces the infarct size. These findings make netrin-1 an important therapeutic target especially with its contradicted effects in physiological and pathophysiological processes. The aim of this review is to highlight the diverse and opposite effects and the functions of netrin-1 signalling during the cardiovascular diseases.

Özet

Laminin benzeri proteinlerin bir ailesi olan netrinler, başlangıçta embriyonik aksonal rehberlikteki rolleri ile tanımlanmıştır. Kemotropik özellik gösteren bu moleküller nöron göçünün iki fonksiyonlu bir düzenleyicisi gibi davranırlar. Araştırmacılar, merkezi sinir sistemindeki rolünden bağımsız olarak netrin-1'in sinir haricindeki dokuların gelişiminde ve oluşumunda rol oynadığını kanıtlamıştırKardiyovasküler alanla ilgili olarak, netrin-1 anjiyogenezi teşvik eder ve aterosklerozu hızlandırır, kalbi iskemi-reperfüzyon hasarına karşı korur ve infarktüs boyutunu azaltır.Bu bulgular, özellikle birçok fizyolojik ve patofizyolojik süreçte birbiriyle çelişebilen etkileri olduğu için netrin-1’i önemli bir terapötik hedef haline getirmektedir. Bu derlemede ateroskleroz, anjiyojenez ve iskemi reperfüzyon onarımı da dahil olmak üzere kardiyovasküler hastalıklar sırasında netrin-1 sinyallerinin işlevleri gözden geçirilmiştir.

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Cite This Article

GÜMÜŞ, L. T., ÜNAL, N. D., GÖRÜR, A. (2022). Role of Netrin-1 in Cardiovascular Diseases. Arşiv Kaynak Tarama Dergisi, Cilt: 27 - Sayı: 4, 440–458. https://ajindex.com/articles/449167

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