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Journals / Erciyes Tıp Dergisi / 2012 / Cilt: 34 - Sayı: 4

Türk populasyonunda glutatyon S-transferaz Z1 gen polimorfizmi

Glutathione S-transferase Z1 gene polymorphism in Turkish population

Sevim ÇELİK KARAKAŞ
Nurcan ATEŞ ARAS
Lülüfer GÜMÜŞ TAMER
Pages
160–164
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the present study the frequency of GSTZ1*A allele was lower than in the other populations.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Glutathione S-Transferase zeta (GSTZ1) is a new member of glutathione S-transferase isoenzymes.
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Key Findings & Data:There are several polymorphic regions in the GSTZ1 gene.
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Conclusion & Impact:In the present study the frequency of GSTZ1*A allele was lower than in the other populations.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Glutathione S-Transferase zeta (GSTZ1) is a new member of glutathione S-transferase isoenzymes. There are several polymorphic regions in the GSTZ1 gene. The result of two base changes at nucleotide positions 94 and 124, GSTZ1 gene has four alleles, GSTZ1*A (A94A124), GSTZ1*B (A94G124), GSTZ1*C (G94G124) and GSTZ1*D (G94A124). The aim of the present study was to investigate the distribution of GSTZ1 gene polymorphism in the Turkish population. Material and Methods: Eighty unrelated healthy subjects who were admitted to the hospital from the Mersin region were included in the study and DNA samples were extracted from the lymphocytes by using High Pure Template Preparation Kit. The polymorphism of GSTZ1 was performed by PCR-RFLP in Turkish population. Results: The distributions of GSTZ1*A, GSTZ1*B, GSTZ1*C and GSTZ1*D allele frequencies are 1.2%, 20%, 76.9% and 1.9%, respectively. Conclusion: This study presents the first results of GSTZ1 allele distributions in the Turkish population. In the present study the frequency of GSTZ1*A allele was lower than in the other populations.

Özet

Amaç: Glutatyon S-Transferaz zeta (GSTZ1), GST izoenzimlerinin yeni bir üyesidir. GSTZ1 geninde bir çok polimorfik bölge vardır. 94 ve 124. pozisyonlardaki nükleotid değişimleri sonucu GSTZ1’in 4 alleli bulunmaktadır: GSTZ1*A (A94A124), GSTZ1*B (A94G124), GSTZ1*C (G94G124) ve GSTZ1*D (G94A124). Bu çalışmanın amacı Türk Populasyonundaki GSTZ1 gen polimorfizminin dağlımını belirlemektir. Gereç ve Yöntemler: Mersin bölgesinden akraba olmayan 80 sağlıklı bireyin DNA’sı High Pure Template Preparation Kiti kullanılarak lenfositlerden izole edilmiştir. Türk Populasyonundaki GSTZ1 polimorfizmi PCR-RFLP yöntemi ile belirlenmiştir. Bulgular: GSTZ1*A, GSTZ1*B, GSTZ1*C ve GSTZ1*D allel frekansları sırasasıyla %1,2; %20; %76,9 ve %1,9’dur. Sonuç: Bu çalışmada Türk populasyonunda GSTZ1 allel dağılımını gösteren ilk sonuçlar verilmiştir. GSTZ1*A allel frekansının bu çalışmada diğer populasyonlara oranla daha düşük olduğu tespit edilmiştir.

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Cite This Article

KARAKAŞ, S. Ç., ARAS, N. A., TAMER, L. G. (2022). Türk populasyonunda glutatyon S-transferaz Z1 gen polimorfizmi. Erciyes Tıp Dergisi, Cilt: 34 - Sayı: 4, 160–164. https://ajindex.com/articles/502474

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