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Journals / Atatürk Üniversitesi Veteriner Bilimleri Dergisi / 2018 / Cilt: 13 - Sayı: 2

Effects of Chronically Exposure to Flor and 7,12-Dimethylbenzanthracene (DMBA) on Spermatogenesis and Testicular Histopathology in Rats

Kronik Olarak Flor ve 7,12-Dimetilbenzantrasene (DMBA) Maruz Kalmanın Ratlarda Spermatogenezis ve Testisin Histopatolojisine Etkileri

Gökhan OTO
Hasan UYAR
Saadet BELHAN
Zübeyir HUYUT
Serkan YILDIRIM
Yavuz Selim SAĞLAM
Pages
141–148
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

While there was no change in FSH and LH levels in the groups, testosterone levels were significantly decreased in the other groups according to the control group (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study aimed to investigate the effects of both sodium fluoride (NaF) and polycyclic aromatic hydrocarbon (PAH) derivative such as 7,12-dimethylbenz[a]anthracene (DMBA) singly and in combination on spermatogenesis and testis histopathology in rats.
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Key Findings & Data:Forty male Wistar albino rats weighing 250–300 g used.
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Conclusion & Impact:While there was no change in FSH and LH levels in the groups, testosterone levels were significantly decreased in the other groups according to the control group (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study aimed to investigate the effects of both sodium fluoride (NaF) and polycyclic aromatic hydrocarbon (PAH) derivative such as 7,12-dimethylbenz[a]anthracene (DMBA) singly and in combination on spermatogenesis and testis histopathology in rats. Forty male Wistar albino rats weighing 250–300 g used. On the 90th day of the experiment, intracardiac blood samples and testes were taken. While there was no change in FSH and LH levels in the groups, testosterone levels were significantly decreased in the other groups according to the control group (P

Özet

Bu çalışmada, sıçanlarda florür ve polisiklik aromatik hidrokarbon (PAH) türevi olan 7,12-dimetilbenz [a] antrasen(DMBA)'in spermatogenesis ve testisin histopatolojisi üzerine tek tek ve kombinasyon halinde etkilerinin araştırılmasıamaçlandı. 250-300 g ağırlığında 40 erkek Wistar albino sıçanı kullanıldı. Deneyin 90. gününde intrakardiak kan örnekleri vetestis doku örnekleri alındı. Gruplarda ki FSH ve LH düzeylerinde her hangi bir değişiklik gözükmezken testosteron düzeylerininkontrol grubuna göre diğer gruplarda önemli ölçüde düştüğü belirlendi (P

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Cite This Article

OTO, G., UYAR, H., BELHAN, S., HUYUT, Z., YILDIRIM, S., SAĞLAM, Y. S. (2022). Effects of Chronically Exposure to Flor and 7,12-Dimethylbenzanthracene (DMBA) on Spermatogenesis and Testicular Histopathology in Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, Cilt: 13 - Sayı: 2, 141–148. https://ajindex.com/articles/448281

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References (14)

  1. Choubisa SL., 1999. Some observations on endemic fluorosis in domestic animals in Southern Rajasthan (India). Vet Res Com, 23, 457- 465
  2. Donmez N., Cinar DA., 2003. Effects of chronic fluorosis on electrocardiogram in sheep. Biol Trace Elem Res, 92, 115-122
  3. Mert H., Comba B., Mert N., Çınar DA., Apaydın Yıldırım B., 2016. Advanced oxidation protein products AOPP levels and kidney function in fluorotic sheep. Fluoride, 49, 336-342
  4. Yildirim S., Oto G., Comba B., Ekin S., Cinar DA., 2017. The investigation of protective effects of resveratrol on biochemical and histopathological parameters in induced experimentally chronic fluorosis in rats. Fluoroide, 50(2 Pt 2): (in press)
  5. Suska M., 2002. Energy metabolism of erythrocytes in lambs chronically exposed to fluorine compounds. Acta Vet Brno, 71, 313-317
  6. Kilicalp D., Cinar A., Belge F., 2004. Effects of chronic fluorosis on electrocardiogram in dogs. Fluoride, 37, 96-101
  7. Cinar DA., Selcuk M., 2005. Effects of chronic fluorosis on thyroxine, triiodothyronine, and protein-bound iodine in cows. Fluoride, 38, 65- 68
  8. Comba B., Cinar DA., 2016. Investigation of effects of fluorosis on some minerals and hormones in sheep. Ankara Üniv Vet Fak Derg, 63, 223-227
  9. Yildirim S., Ekin S., Huyut Z., Oto G., Comba A., Uyar H., Sengul E., Cinar DA., 2017. Effect of chronic exposure to sodium fluoride and 7,12- dimethylbenz[a]anthracene on some blood parameters and histopathological findings in rats. Fluoroide, 50(3 Pt 2): (in press)
  10. Baek SO., Field RA., Goldstone ME., Kirk PW., Lester JN., Perry R., 1991. A review of atmospheric polycyclic aromatic hydrocarbons: sources, fate and behavior. Water Air Soil Pollut, 60, 279-300
  11. Dickhut RM., Gustafson KE., 1995. Atmospheric washout of polycyclic aromatic hydrocarbons in the Southern Chesapeake Bay region. Environ Sci Technol, 29, 1518-1525
  12. Hillery BR., Simcik MF., Basu I., Hoff RM., Strachan WMJ., Burniston D., Chan CH., Brice KA., Sweet CW., Hites RA., 1998. Atmospheric deposition of toxic pollutants to the Great Lakes as measured by the integrated atmospheric deposition network. Environ Sci Technol, 32, 2216-2221
  13. Carrera G., Fernandez P., Vilanova RM., Grimalt JO., 2001. Persistent organic pollutants in snow from European high mountain areas. Atmos Environ, 35, 245-254
  14. Ersan Y., Koç E., Ari İ., Karademir B., 2010. Histopathological effects of chronic fluorosis on the liver of mice (Swiss albino). Turk J Med Sci, 40, 619-622.