Journals / Anadolu Tıp Dergisi / 2000 / Cilt: 2 - Sayı: 2

Relation between chronic Helicobacter pylori infection and plasma fibrinogen and lipid

Kronik Helicobacter pylori enfeksiyonu ile plazma fibrinojen ve lipid ilişkisi

Pages
119–123
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There were no significant differences in regard to the plasma fibrinogen and blood lipid values between H. pylori positive and negative groups.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In researches on the risk factors of coronary artery disease (CAD), it is indicated that the level of plasma fibrinogen is an independent risk factor and increases the risk of CAD.
📊
Key Findings & Data:Chlamydia pneumoniae and Helicobacter pylori (H. pylori) are regarded as the most significant microorganisms.
💡
Conclusion & Impact:There were no significant differences in regard to the plasma fibrinogen and blood lipid values between H. pylori positive and negative groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In researches on the risk factors of coronary artery disease (CAD), it is indicated that the level of plasma fibrinogen is an independent risk factor and increases the risk of CAD. In the recent years, it has been stated that certain chronic infections may, also, be a risk factor for CAD. Chlamydia pneumoniae and Helicobacter pylori (H. pylori) are regarded as the most significant microorganisms. In some researches, H. pylori is found as a risk factor for CAD; where as, others could not find any positive correlations. In the present study, plasma fibrinogen and lipid levels of patients with dyspeptic complaints were measured and the results were compared between H. pylori positive and negative cases. H. pylori positive and negative cases were determined due to a histological investigation. Patients with diabetes mellitus, hypertension, heart and liver diseases were excluded. Out of 62 cases (mean age: 42.4±13.5) 32 cases (mean age:47.5±l 1.5) were H. pylori positive whereas 30 cases (mean age: 37.1±13.6) were H. pylori negative. The plasma fibrinogen, cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol levels in the H. pylori positive group was; 262.2±72.4 mg/dl., 200.9±46.9 mg/dl., 153.5±80. mg/dl., 45.6±25.5 mg/dl, 127.9±40.4 mg/dl., 31.9±15.7 mg/dl, respectively whereas, the results of the H. pylori negative group was; 251.7±104.2, 203.6±70.2, 154.9±91.1, 49.±10.7, 121.6±45.6, 32.1±17.9, in the same order. There were no significant differences in regard to the plasma fibrinogen and blood lipid values between H. pylori positive and negative groups.

Özet

Koroner arter hastalığı (KAH) risk faktörleri üzerine yapılan çalışmalarda, plazma fibrinojen düzeyinin diğer risk faktörlerinden bağımsız olarak KAH riskini artırdığı gösterilmiştir. Son yıllarda bazı kronik infeksiyonların KAH için risk faktörü olabileceği bildirilmektedir. Clamydia pneumoniae ve Helicobacter pylori (H. pylori) bu enfeksiyonların en çok dikkati çekeni ve araştırılanı olmuştur. H. pylori çalışmaların çoğunda KAH için risk faktörü olarak bulunsa da bazılarında ilişki gösterilememiştir. Bu çalışmada, dispeptik yakınmaları olan, diabet, hipertansiyon, kalp ve karaciğer vb. gibi hastalıkları olmayan, üst endoskopik muayenede gastrit, ülser vb. gibi patolojileri olan, histolojik tetkikte H. pylori pozitif ve negatif saptanan olgularda, plazma fibrinojen ve lipoproteinleri ölçülerek her iki grubun sonuçlan karşılaştırıldı. Toplam 62 olgunun (ortalama yaş: 42.4±13.5) 32'sinde (ortalama yaş: 47.5±11.5) H.pylori pozitif iken 30 olguda (ortalama yaş: 37±13.6) H. pylori negatif idi. H. pylori pozitif gruptaki değerler; fibrinojen: 262.2±72.4 mg/dl, kolesterol: 200.9±46.9 mg/dl, trigliserit: 153.5+80. mg/dl, HDL kolesterol: 45.6±25.5 mg/dl, LDL kolesterol: 127.9±40.4 mg/dl, VLDL kolesterol: 31.9±15.7 mg/dl iken negatif grupta bu değerler sırasıyla; 251.7±104.2, 203.6±70.2, 154.9±91.1, 49±10.7, 121.6±45.6, 32.1±17.9 idi. Sonuçlar karşılaştırıldığında, H. pylori pozitif ve negatif gruplar arasında plazma fibrinojen ve kan lipitleri açısından anlamlı fark bulunmadı.

🔖

Cite This Article

DEMİRCİ, F., OKAN, V., ARAZ, M., KEPEKÇİ, Y., ERKILIÇ, S., AKTARAN, Ş., ÖZTUZCU, S. (2022). Relation between chronic Helicobacter pylori infection and plasma fibrinogen and lipid. Anadolu Tıp Dergisi, Cilt: 2 - Sayı: 2, 119–123. https://ajindex.com/articles/438185

References (16)

  1. Danesh J, Peto R. Risk factors for coronary heart disease and Helicobacter pylori: meta-analysis of 18 studies. BMJ 1998;316:1130-2
  2. Jousilahti P, Saloma V, Rasi V, Vahtera E. The asocation between symptom of chronic bronchitisand plasma fibrinogen level. Circulation 1997;96 (suppl 1) 1-655
  3. Kannel WB,Wolf PA, Castelli WP, D'Agostino RB. Fibrinogen and risk of cardiovascular disease: the Framingham Study. JAMA, 1987;258:1183-86
  4. Maseri A. Inflammation, atherosclerosis and ischaemic events; exploring the hidden side of the moon. N Eng J Med 1997;336:1014-6
  5. Mendall MA, Goggin PM, Molineaux N, et al. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 1994; 71: 437-9
  6. Murray LJ, Bamford KB, O'Reilly DPJ, McCrum EE, Evans A. Helicobacter pylori infection: relation with cardiovascular risk factors, ischaemic heart disease, and social class. Br Heart J 1995; 74: 497-501
  7. Niemela S, Kartunen T, et al. Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum lipid concentrations? Heart 1996;75:573-75
  8. Nieminen MS, Manila K, Valtonen V. Infectionand inflammations as risk formyocardial infarction. Eur Heart J 1993; 14:12-16 9. Oliver MF. Fibrinogen and coronary heart disease-what does it mean? Eur Heart J 1998;19: 8-9
  9. Pasceri V,Cammarota G, Patti G, et all.Association of virulent Helicobacter pylori strains with ischaemic heart disease.Circulation, 1998; 97: 1675-79
  10. Patel P, Mendall MA, Carrington D, et al.Association of Helicobacter pylori and clamydia pneumoniaeinfections with coronary heart disease and cardiovascular risk factors. BMJ 1995:311:711-714
  11. Pieniazek P. Association of Helicobacter pylori infection with coronary heart disease. J Physiol Pharmacol 1999;50:743-751
  12. Pober JS, Warner-Lambert/ Parke-Davis award lecture. Cytokine- mediated activation of vascular endothelium. Physiology and Pathology. Am J Pathol 1988;133: 426-433
  13. Rasi V, Ikkala E, Valtonen V. Plasma betathromboglobulin in severe infection. Thromb Res 1982; 26: 267-274
  14. Wald NJ, Law MR, Morns JK, Bagnall AM. Helicobacter pylori infection and mortality from ischaemic heart disease: negative results from a large, prospective study. BMJ 1997;315: 1199-1201
  15. Whincup PH, Mendall MA, Perry IJ, et al. Prospective relations between Helicobacter pylori infection, coronary heart disease and stroke in middle aged men. Heart 1996;75:568-572
  16. Woodward M, Lowe GDO, Rumley A,