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Journals / Anadolu Kardiyoloji Dergisi / 2004 / Cilt: 4 - Sayı: 4

The effects of simvastatin combined with different antioxidant vitamin regimens on serum lipid profile in patients with low HDL cholesterol levels

HDL kolesterol düzeyi düşük olan bireylerde statin tedavisine farklı antioksidan vitaminlerin eklenmesinin serum lipid profili üzerine etkisi

Aylin YILDIRIR
Bülent ÖZİN
Mehmet Emin KORKMAZ
Egemen TAYFUN
Haldun MÜDERRİSOĞLU
Serpil EROĞLU
Melek ULUÇAM
Bahar PİRAT
Pages
318–322
Publication Date
2022-10-10
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The groups’ lipid profiles were obtained at baseline, 3rd and 6th months.Results: Comparing with baseline values, total-C and low density cholesterol (LDL-C) values significantly reduced (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study was designed to compare the effects of simvastatin versus a combination of simvastatin with vitamin C or E on serum lipid profile, particularly, high density lipoprotein (HDL)-cholesterol (C) level, in patients with a low HDL-C level.
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Key Findings & Data:Methods: Fifty-nine women and 49 men, who had a baseline HDL-C level equal to or lower than 40 mg/dl were randomized to one of the following study treatment groups: Group S (n=39) simvastatin 20 mg/day, Group S+C (n=33) simvastatin 20 mg/day + vitamin C 500 mg/day, and Group S+E (n=36) simvastatin 20 mg/day + vitamin E 400 IU/day.
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Conclusion & Impact:The groups’ lipid profiles were obtained at baseline, 3rd and 6th months.Results: Comparing with baseline values, total-C and low density cholesterol (LDL-C) values significantly reduced (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study was designed to compare the effects of simvastatin versus a combination of simvastatin with vitamin C or E on serum lipid profile, particularly, high density lipoprotein (HDL)-cholesterol (C) level, in patients with a low HDL-C level. Methods: Fifty-nine women and 49 men, who had a baseline HDL-C level equal to or lower than 40 mg/dl were randomized to one of the following study treatment groups: Group S (n=39) simvastatin 20 mg/day, Group S+C (n=33) simvastatin 20 mg/day + vitamin C 500 mg/day, and Group S+E (n=36) simvastatin 20 mg/day + vitamin E 400 IU/day. The groups’ lipid profiles were obtained at baseline, 3rd and 6th months.Results: Comparing with baseline values, total-C and low density cholesterol (LDL-C) values significantly reduced (p

Özet

Amaç: Bu çalışmada serum yüksek yoğunluklu lipoprotein-kolesterol (HDL-K) düzeyi düşük bireylerde simvastatin tedavisine, farklı antioksidan vitaminlerin eklenmesinin serum lipid profili, özellikle de HDL-K üzerine olan etkilerinin saptanması amaçlandı.Yöntemler: Bilinen koroner arter hastalığı (KAH) veya KAH için en az bir risk faktörü olan HDL-K düzeyi 40 mg/dl veya altında, 59’u kadın, 49’u erkek 108 hasta çalışmaya alındı. Hastalar simvastatin 20 mg/gün (Grup S, n=39), simvastatin 20 mg/gün+vitamin C 500 mg/gün (Grup S+C, n=33), simvastatin 20 mg/gün+vitamin E 400 IU/gün (Grup S+C, n=36) gruplarına randomize edildi. Başlangıç, 3. ve 6. aylarda lipid profilleri değerlendirildi.Bulgular: Başlangıç ortalama total-K, trigliserid, düşük yoğunluklu lipoprotein kolesterol (LDL-K) ve HDL-K değerleri sırasıyla 217 mg/dl, 199 mg/dl, 135 mg/dl ve 35 mg/dl idi. Tedavi sonrası, başlangıç değerlerine göre tüm gruplarda total ve LDL-K düzeylerinde anlamlı azalma (p

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Cite This Article

YILDIRIR, A., ÖZİN, B., KORKMAZ, M. E., TAYFUN, E., MÜDERRİSOĞLU, H., EROĞLU, S., ULUÇAM, M., PİRAT, B. (2022). The effects of simvastatin combined with different antioxidant vitamin regimens on serum lipid profile in patients with low HDL cholesterol levels. Anadolu Kardiyoloji Dergisi, Cilt: 4 - Sayı: 4, 318–322. https://ajindex.com/articles/437448

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