Journals / Anadolu Kardiyoloji Dergisi / 2009 / Cilt: 9 - Sayı: 4

Koroner yavaş akımlı hastalarda nebivololün P dalga süresi ve dispersiyonuna etkileri

The effects of nebivolol on P wave duration and dispersion in patients with coronary slow flow

Pages
290–295
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Unpaired and paired t-tests, Chi-square test, Mann-Whitney’s U-test and Pearson correlation analysis were used in statistical analysis.Results: Compared to control group maximum P wave duration (Pmax) (104.3±12.2 vs. 93.4±9.8 msec, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries in the absence epicardial occlusive disease.
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Key Findings & Data:Nebivolol, besides its selective beta1-blocking activity, causes an endothelium dependent vasodilatation through nitric oxide release.
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Conclusion & Impact:Unpaired and paired t-tests, Chi-square test, Mann-Whitney’s U-test and Pearson correlation analysis were used in statistical analysis.Results: Compared to control group maximum P wave duration (Pmax) (104.3±12.2 vs. 93.4±9.8 msec, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries in the absence epicardial occlusive disease. P wave duration and dispersion have been reported to be longer in patients with CSF. Nebivolol, besides its selective beta1-blocking activity, causes an endothelium dependent vasodilatation through nitric oxide release. In this study, we searched for the association between left ventricular diastolic functions and atrial conduction dispersion, the effects of nebivolol on P wave duration and dispersion in patients with CSF.Methods: This prospective case-controlled study included 30 patients having CSF and 30 subjects having normal coronary arteries in coronary angiography. The patients were evaluated with 12-leads electrocardiography and echocardiography before and three months after treatment with nebivolol. The difference between maximum and minimum P wave durations was defined as P-wave dispersion (PWD). Early diastolic flow (E), atrial contraction wave (A) and E deceleration time (DT) and isovolumetric relaxation time (IVRT) were measured. Unpaired and paired t-tests, Chi-square test, Mann-Whitney’s U-test and Pearson correlation analysis were used in statistical analysis.Results: Compared to control group maximum P wave duration (Pmax) (104.3±12.2 vs. 93.4±9.8 msec, p

Özet

Amaç: Koroner yavaş akım (KYA) epikardiyal tıkayıcı bir hastalık olmaksızın koroner arterlerde opaklaşmanın gecikmesi ile karakterizedir. P dalga süresi ile dispersiyonunun KYA olan hastalarda uzadığı bildirilmiştir. Nebivolol, beta1-bloker aktivitesinin olması yanı sıra, nitrik oksit salınımı ile endotele bağımlı vazodilatasyona yol açar. Bu çalışmada KYA olan hastalarda sol ventrikül diyastolik fonksiyonları ile atriyal iletim dispersiyonu arasındaki ilişkiyi ve nebivololün P dalga dispersiyonu (PWD) üzerindeki etkilerini araştırdık.Yöntemler: Prospektif, vaka-kontrollü bu çalışmaya koroner anjiyografide KYA saptanan 30 hasta ve koroner arterleri normal bulunan 30 birey alındı. Hastalar nebivolol tedavisinden önce ve üç ay sonra 12-derivasyonlu elektrokardiyografi ve ekokardiyografi ile değerlendirildiler. Maksimum ve minimum P dalga süreleri arasındaki fark PWD olarak tanımlandı. Erken diyastolik akım (E), atriyal kasılma dalgası (A), E deselarasyon zamanı (DT) ile izovolumetrik gevşeme zamanı (IVRT) ölçüldü. İstatistiksel analizde t-testleri, Ki-kare testi, Mann-Whitney U-testi ve Pearson korelasyon analizi kullanıldı.Bulgular: Kontrol grubuna göre KYA olan hastalarda maksimum P dalga süresi (Pmax) (104.3±12.2 karşın 93.4±9.8 msn, p

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Cite This Article

TUNCER, M., GÜNEŞ, Y., CEYHAN, Y., GÜNTEKİN, Ü. (2022). Koroner yavaş akımlı hastalarda nebivololün P dalga süresi ve dispersiyonuna etkileri. Anadolu Kardiyoloji Dergisi, Cilt: 9 - Sayı: 4, 290–295. https://ajindex.com/articles/436947

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