Sistemik lupus eritematozda insülin direnci oksidatif stres ile ilişkilidir

Statistical analyses were performed using Kruskal-Wallis, Mann-Whitney U and Pearson tests.Results: In the SLE group, TNF-a (7.9 [0.5-57.8] vs. 3.9 [0.3-6.3] pg/ml, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Systemic lupus erythematosus (SLE) patients have increased risk of coronary heart disease (CHD) that cannot be fully explained by the traditional risk factors.

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Key Findings & Data:Metabolic alterations like oxidative stress and insulin resistance may be additional risk factors to contribute early and accelerated atherosclerosis in SLE.

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Conclusion & Impact:Statistical analyses were performed using Kruskal-Wallis, Mann-Whitney U and Pearson tests.Results: In the SLE group, TNF-a (7.9 [0.5-57.8] vs. 3.9 [0.3-6.3] pg/ml, p

🔬Design:Modeling & Simulation

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: Systemic lupus erythematosus (SLE) patients have increased risk of coronary heart disease (CHD) that cannot be fully explained by the traditional risk factors. Metabolic alterations like oxidative stress and insulin resistance may be additional risk factors to contribute early and accelerated atherosclerosis in SLE. Our aim was to evaluate malondialdehyde (MDA) level, oxidative stress indicator, and homeostasis model assessment of insulin resistance (HOMA-IR), and possible relationship between oxidative stress and insulin resistance, in SLE.Methods: This cross-sectional controlled study included 30 SLE patients (SLE group) and 15 age- and sex-matched healthy controls (HC group). The SLE patients were classified into subgroups based on the disease activity index as active or inactive. Serum MDA, insulin, C-peptide, fasting blood glucose, lipid profile, acute phase reactants, tumor necrosis factor (TNF)-a, interleukin (IL)-6 and HOMA-IR were determined. Statistical analyses were performed using Kruskal-Wallis, Mann-Whitney U and Pearson tests.Results: In the SLE group, TNF-a (7.9 [0.5-57.8] vs. 3.9 [0.3-6.3] pg/ml, p

Özet

Amaç: Sistemik lupus eritematoz (SLE) hastalarında, koroner kalp hastalığı (KKH) riskinde artış olduğu kanıtlanmıştır. Ancak KKH riskindeki bu artış çoğu zaman klasik risk faktörleri ile açıklanamamaktadır. Sistemik lupus eritematozdaki erken ve hızlanmış aterosklerozdan, ek risk faktörleri olarak, oksidatif stres ve/veya insülin direnci gibi metabolik değişiklikler sorumlu olabilir. Bu çalışmada, SLE hastalarında, oksidatif stres indikatörü malondialdehit (MDA) düzeyi ve ``homeostasis model assessment of insulin resistance`` (HOMA-IR) indeksinin belirlenmesi ve oksidatif stres ile insülin direnci arasındaki olasılı ilişkinin değerlendirilmesi amaçlandı.Yöntemler: Bu enine kesitli kontrollü çalışmaya, 30 SLE hastası (SLE grubu) ile yaş ve cinsiyet uyumlu 15 sağlıklı gönüllü (kontrol grubu) alındı. Sistemik lupus eritematoz hastaları, hastalık aktivite indeksi skoruna göre, aktif ve inaktif olarak alt gruplara ayrıldı. Serum MDA, insülin, C-peptid, açlık kan glukozu, lipit profili, akut faz reaktanları, tumor nekrozis alpha faktör (TNF-a) ve interlökin (IL)-6 düzeyleri belirlendi ve HOMA-IR indeksi hesaplandı. İstatistiksel analizlerde Kruskal Wallis, Mann-Whitney U ve Pearson testleri kullanıldı.Bulgular: Sistemik lupus eritematoz grubunda, kontrol grubuna göre TNF-a (7.9 [0.5-57.8] karşın 3.9 [0.3-6.3] pg/ml, p

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Cite This Article

KARACA, I., DAĞLI, N., KOCA, S. S., IŞIK, A., ÖZGEN, M., YAVUZKIR, M. F., ÜSTÜNDAĞ, B. (2022). Sistemik lupus eritematozda insülin direnci oksidatif stres ile ilişkilidir. Anadolu Kardiyoloji Dergisi, Cilt: 9 - Sayı: 1, 23–28. https://ajindex.com/articles/436875

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