SavedAdd your journal

Journals / Anadolu Kardiyoloji Dergisi / 2009 / Cilt: 9 - Sayı: 4

Kardiyopulmoner baypasın indüklediği sistemik inflamatuvar yanıt sendromunda intraoperatif amiodaron yüklemesinin etkisi

The effects of intra-operative amiodarone loading on the systemic inflammatory response syndrome induced by cardiopulmonary bypass

Handan AKBULUT
Mehmet ÖZDEN
Mustafa Kemal BAYAR
Oktay BURMA
Ayhan UYSAL
Ali RAHMAN
Pages
318–324
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Statistical analyses were performed using Mann-Whitney U, Fischer’s exact and ANOVA tests.Results: In both groups, the IL-6 levels significantly increased after declamping (91.18±16.27 pg/ml and 86.37±14.66 pg/ml, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Cardiopulmonary bypass (CPB) leads to systemic inflammatory response syndrome (SIRS).
📊
Key Findings & Data:Methods: This prospective randomized study included 24 patients who underwent on-pump coronary artery surgery.
💡
Conclusion & Impact:Statistical analyses were performed using Mann-Whitney U, Fischer’s exact and ANOVA tests.Results: In both groups, the IL-6 levels significantly increased after declamping (91.18±16.27 pg/ml and 86.37±14.66 pg/ml, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Cardiopulmonary bypass (CPB) leads to systemic inflammatory response syndrome (SIRS). In vitro studies showed that amiodarone blocked cytokine production. The aim of this study was to evaluate the effect of intra-operative amiodarone loading on SIRS. Methods: This prospective randomized study included 24 patients who underwent on-pump coronary artery surgery. The patients were classified into control (n=12) and amiodarone (n=12) groups. Plasma levels of the pro-inflammatory (C-reactive protein - CRP, interleukin-6 - IL-6) and the anti-inflammatory markers (interleukin-10 - IL-10) were measured before the induction of anesthesia, 5 minutes after aortic declamping, after protamine administration and 24 hours after the CPB. The myocardial lactate production was calculated before CPB and 5 minutes after aortic declamping. Statistical analyses were performed using Mann-Whitney U, Fischer’s exact and ANOVA tests.Results: In both groups, the IL-6 levels significantly increased after declamping (91.18±16.27 pg/ml and 86.37±14.66 pg/ml, p

Özet

Amaç: Kardiyopulmoner baypas (KPB) sistemik inflamatuvar yanıt sendromuna (SIYS) yol açmaktadır. In vitro çalışmalarda amiodaronun sitokin üretimini bloke ettiği gösterilmiştir. Bu çalışmanın amacı intraoperatif amiodaron yüklemesinin KPB’ın indüklediği SIYS’da etkisini değerlendirmektir.Yöntemler: Bu prospektif, randomize çalışmaya pompa eşliğinde koroner arter baypas cerrahisi uygulanan 24 hasta alındı. Hastalar kontrol (n=12) ve amiodaron (n=12) olarak 2 alt gruba ayrıldı. Proinflamatuvar (C-reaktif protein - CRP, interlökin -6 - IL-6) ve antiinflamatuvar (interlökin-10, IL-10) belirteçlerin plasma düzeyleri anestezi indüksiyonu öncesi, aortik kros klempin alınması sonrası 5. dakikada, protamin sonrası ve postoperatif 24. saatte ölçüldü. Miyokardiyal laktat üretimi KPB öncesi ve aortik klempin alınması sonrası 5. dakikada hesaplandı. İstatistiksel analizlerde Mann-Whitney U, Fischer’s exact ve ANOVA testleri kullanıldı. Bulgular: Her 2 grupta IL-6 seviyeleri aortik kros klemp kaldırıldıktan sonra belirgin arttı (91.18±16.27 pg/ml ve 86.37±14.66 pg/ml, p

🔖

Cite This Article

AKBULUT, H., ÖZDEN, M., BAYAR, M. K., BURMA, O., UYSAL, A., RAHMAN, A. (2022). Kardiyopulmoner baypasın indüklediği sistemik inflamatuvar yanıt sendromunda intraoperatif amiodaron yüklemesinin etkisi. Anadolu Kardiyoloji Dergisi, Cilt: 9 - Sayı: 4, 318–324. https://ajindex.com/articles/436855

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Levy JH, Tanaka KA. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg 2003; 75: S715-20
  2. Paparella D, Yau TM, Young E. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur Cardiothoracic Surg 2002; 21: 232-44
  3. Bourbon A, Vionnet M, Leprince P, Vaissier J, Copelend J, McDonagh P, et al. The effect of methylprednisolone treatment on the cardiopulmonary bypass-induced systemic inflammatory response. Eur J Cardiothorac Surg 2004; 21: 932-8
  4. Giomarelli P, Scolletta S, Borrelli E, Biagioli B. Myocardial and lung injury after cardiopulmonary bypass: role of interleukin (IL)-10. Ann Thorac Surg 2003; 76: 117-23
  5. Krakauer T. IL-10 inhibits the adhesion of leukocytic cells to IL-1 activated human endothelial cells. Immunol Lett 1995; 45: 61-5
  6. Wu ZK, Pehkonen E, Laurikka J, Kaukinen L, Honkonen EL, Kaukinen S, et al. Myocardial lactate production is not involved in the ischemic preconditionng mechanism in coronary artery bypass graft surgery patients. J Cardiothorac Vasc Anesth 2001; 15: 412-7
  7. Akins CW, Boucher CA, Pohost GM. Preservation of interventricular septal function in patients having coronary artery bypass grafts without cardiopulmonary bypass. Am Heart J 1984; 107: 304-9
  8. DiDomenico RJ, Massad MG. Pharmacologic strategies for prevention of atrial fibrillation after open heart surgery. Ann Thorac Surg 2005; 79: 728-40
  9. Matsumori A, Ono K, Nishio R, Nose Y, Sasayama S. Amiodarone inhibits production of tumor necrosis factor-α by human mononuclear cells. Circulation 1997; 96: 1386-9
  10. Karpel JP, Mitsudo S, Norin A. Natural kiler cell activity in a rat model of amiodarone-induced interstitial lung disease. Chest 1991; 99: 230-4
  11. Karth GD, Buberl A, Nikfardjam M, Meyer B, Wollenek G, Grimm M, et al. Role of amiodarone on the systemic inflammatory response induced by cardiac surgery: proinflammatory actions. Can J Anesth 2007; 54: 262-8
  12. Nieman G, Searles B, Carney D, Mccann U, Schiller H, Lutz C. Systemic inflammation induced by cardiopulmonary bypass: a review of pathogenesis and treatment. J Extra Corpor Technol 1999; 31: 202-10
  13. Sawa Y, Ichikawa H, Kagisaki K, Ohata T, Matsuda H. Interleukin-6 derived from hypoxic myocytes promotes neutrophil-mediated reperfusion injury in myocardium. J Thorac Cardiovasc Surg 1998; 116: 511-7
  14. Biancari F, Lahtinen J, Lepojarvi S, Rainio P, Salmella E, Pokela R. Preoperative C reactive protein and outcome after coronary artery