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Journals / Solunum Hastalıkları / 2002 / Cilt: 13 - Sayı: 4

Serum immunoglobulin levels of chronic obstructive pulmonary disease cases and healthy current smokers

Kronik obstrüktif akciğer hastalığı olan ve sigara içen sağlıklı olgularda serum immünglobulin düzeyleri

FİGEN DEVECİ
Teyfik TURGUT
HATİCE HANDAN AKBULUT
Gamze KIRKIL
M. Hamdi MUZ
Pages
246–255
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We observed that smoking reduced serum IgG, lgC2 and IgM levels but there was no relation between number of exacerbations in COPD cases and serum IgC and lgG2 levels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:We aimed to investigate the relation between recurrent pulmonary infections and IgG and subclasses levels and to determine serum Ig levels in current smokers with chronic obstructive pulmonary disease (COPD) and asymptomatic smokers.
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Key Findings & Data:Three groups were included in the study; current smoker with COPD (n= 30), asymptomatic smokers (n= 15) and never smokers (n=15).
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Conclusion & Impact:We observed that smoking reduced serum IgG, lgC2 and IgM levels but there was no relation between number of exacerbations in COPD cases and serum IgC and lgG2 levels.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:IgM · IgG · IgA

Abstract

We aimed to investigate the relation between recurrent pulmonary infections and IgG and subclasses levels and to determine serum Ig levels in current smokers with chronic obstructive pulmonary disease (COPD) and asymptomatic smokers. Three groups were included in the study; current smoker with COPD (n= 30), asymptomatic smokers (n= 15) and never smokers (n=15). Serum IgG, IgA, IgM and IgG subclasses were assessed in cases who have inclusion criteria. Serum IgG levels were significantly lower in both COPD cases and asymptomatic smokers than never smokers (respectively; p= 0.001, p= 0.002). Similarly lgG2 level was significantly lower in both COPD cases and asymptomatic smokersthan never smokers (p< 0.001). Serum IgA levels were significantly higher in COPD cases than asymptomatic smokers (p= 0.002). Serum IgM levels were significantly lower in COPD cases than never smokers (p< 0.001). When COPD cases were divided in two groups depend on number of exacerbations (number of exacerbations $\leq$ 4 and > 4 in recent 2 years) there was no difference between IgC and lgG2 levels. We observed that smoking reduced serum IgG, lgC2 and IgM levels but there was no relation between number of exacerbations in COPD cases and serum IgC and lgG2 levels.

Özet

Çalışmamızda halen sigara içmeye devam eden kronik obstrüktif akciğer hastalığı (KOAH) olan olgularda, asemptomatik sigara içicilerde serum İmmünglobulin (lg) düzeylerinin belirlenmesi ve tekrarlayan solunum yolu infeksiyonlarının, IgG ve alt gruplarının seviyeleri ile ilişkisinin araştırılması amaçlandı. Sigara içen KOAH (n= 30)'lılar, asemptomatik sigara içiciler (n= 15) ve hiç sigara içmemiş (n= 15) olgulardan oluşan 3 grup oluşturuldu. Çalışmaya dahil edilme kriterlerine uyan olgularda serum IgG, IgA, IgM ve IgG subtip düzeyleri ölçüldü. IgG düzeyi hem KOAH'lı hem de asemptomatik içicilerde hiç sigara içmeyen olgulara göre anlamlı ölçüde düşük bulundu (sırasıyla; p= 0.001, p= 0.002). lgG2 düzeyi de KOAH'lı ve asemptomatik içicilerde hiç sigara içmeyen olgulara göre anlamlı derecede düşüktü (p 4 olanlar) IgG ve lgG2 düzeyleri arasında fark saptanmadı. Sigara içiminin serum IgG, lgG2 ve IgM düzeylerini azalttığı, ancak KOAH'lı olgularda atak sayısı ile IgG ve lgG2 düzeyleri arasında ilişki olmadığı gözlendi.

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Cite This Article

DEVECİ, F., TURGUT, T., AKBULUT, H. H., KIRKIL, G., MUZ, M. H. (2002). Serum immunoglobulin levels of chronic obstructive pulmonary disease cases and healthy current smokers. Solunum Hastalıkları, Cilt: 13 - Sayı: 4, 246–255. https://ajindex.com/articles/318663

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