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Journals / Anadolu Kardiyoloji Dergisi / 2010 / Cilt: 10 - Sayı: 1

Fındık tüketimi normolipidemik sağlıklı kişilerde LDL’nin oksidasyona duyarlılığını, plazma okside LDL düzeyini azaltır ve büyük/küçük LDL oranını arttırır

Hazelnut consumption decreases the susceptibility of LDL to oxidation, plasma oxidized LDL level and increases the ratio of large/small LDL in normolipidemic healthy subjects

Asım ÖREM
İbrahim TURAN
Balaban Fulya YÜCESAN
Vanizor Birgül KURAL
Cihan ÖREM
Pages
28–35
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Total cholesterol, LDL-cholesterol, apolipoprotein (apo) B and apo B/apo AI ratio were found to be significantly lower while apo AI was higher (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Nut consumption has beneficial effects on protection for development of atherosclerotic process.
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Key Findings & Data:Methods: Single intervention study design was used to determine the effects of hazelnut-enriched diet (1 g/kg/day) during 4 weeks period on atherogenic tendency of low-density lipoprotein (LDL) by evaluating susceptibility of LDL to oxidation, α-tocopherol content of LDL, LDL subfractions, plasma oxidized (ox) LDL, lipid and lipoprotein levels in normolipidemic healthy subjects (n=21).
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Conclusion & Impact:Total cholesterol, LDL-cholesterol, apolipoprotein (apo) B and apo B/apo AI ratio were found to be significantly lower while apo AI was higher (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Nut consumption has beneficial effects on protection for development of atherosclerotic process. Methods: Single intervention study design was used to determine the effects of hazelnut-enriched diet (1 g/kg/day) during 4 weeks period on atherogenic tendency of low-density lipoprotein (LDL) by evaluating susceptibility of LDL to oxidation, α-tocopherol content of LDL, LDL subfractions, plasma oxidized (ox) LDL, lipid and lipoprotein levels in normolipidemic healthy subjects (n=21). Statistical analysis was performed using paired t test, ANOVA for repeated measurements test, Pearson’s and Spearman correlation analyses. Results: Lag time for oxidation (baseline 54.6±12.3 min, 15th day 59.3±13.4 min, 30th day 65.2±17.8 min, p=0.001) and α-tocopherol content of LDL (baseline 4.82±1.2 μg/mg LDL protein, 15th day 4.88±1.4 μg/mg LDL protein, 30th day 5.35±1.7 μg/mg LDL protein, p=0.02) were found to be increased while ox-LDL levels (baseline 57.2±16.2 U/L, 15th day 51.2±13.6 U/L, 30th day 48.2±14.2 U/L, p=0.001) decreased during the study period. Total cholesterol, LDL-cholesterol, apolipoprotein (apo) B and apo B/apo AI ratio were found to be significantly lower while apo AI was higher (p

Özet

Amaç: Sert kabuklu meyvelerin tüketimi aterosklerotik prosesin gelişimini engellemede faydalı etkiye sahiptir. Yöntemler: Normolipidemik sağlıklı şahıslarda (n=21) fındıkla zenginleştirilmiş diyetin düşük yoğunluklu lipoprotein (LDL)’in aterojenik yatkınlığı üzerine etkisi tek müdahale çalışma dizaynı kullanılarak 4 haftalık periyod boyunca (1 g/kg/gün) LDL’nin oksidasyona duyarlılığı, α-tokoferol miktarı, LDL alt grupları ve plazma okside LDL, lipit ve lipoprotein düzeyleri değerlendirilerek belirlendi. İstatistiksel analizde eşleştirilmiş t, tekrarlayan ölçümler ANOVA testleri, Pearson ve Spearman korelasyon analizleri kullanıldı. Bulgular: Çalışma periyodu esnasında LDL’nin α-tokoferol miktarı (başlangıç 4.82±1.2 μg/mg LDL protein, 15. gün 4.88±1.4 μg/mg LDL protein, 30. gün 5.35±1.7 μg/mg LDL protein, p=0.02) ve LDL oksidasyonu için gecikme zamanı artarken (başlangıç 54.6±12.3 dk, 15. gün 59.3±13.4 dk, 30. gün 65.2±17.8 dk, p=0.001) okside LDL düzeyi azaldı (başlangıç 57.2±16.2 U/L, 15. gün 51.2±13.6 U/L, 30. gün 48.2±14.2 U/L, p=0.001). Toplam kolesterol, LDL kolesterol, apolipoprotein (apo) B ve apo B/apo AI oranı önemli derecede düşük iken apo AI yüksek bulundu (p

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Cite This Article

ÖREM, A., TURAN, İ., YÜCESAN, B. F., KURAL, V. B., ÖREM, C. (2022). Fındık tüketimi normolipidemik sağlıklı kişilerde LDL’nin oksidasyona duyarlılığını, plazma okside LDL düzeyini azaltır ve büyük/küçük LDL oranını arttırır. Anadolu Kardiyoloji Dergisi, Cilt: 10 - Sayı: 1, 28–35. https://ajindex.com/articles/436724

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