Journals / Anadolu Kardiyoloji Dergisi / 2012 / Cilt: 12 - Sayı: 6

Psödoeksfoliyasyon sendromunun yeni bir sistemik göstergesi olarak azalmış aorta kökü esnekliği: Gözlemsel bir çalışma

Decreased aortic root elasticity-as a novel systemic manifestation of the pseudoexfoliation syndrome:

Pages
483–487
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

PEXS may be regarded as a risk factor for cardiovascular and cerebrovascular events.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To assess the aortic root function in patients with pseudoexfoliation syndrome (PEXS).
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Key Findings & Data:Methods: In this case- controlled observational study, aortic root function in 31 PEXS patients (mean age 71±9 years) and 29 controls of similar ages (mean age 69±9 years) were evaluated by M-mode transthoracic echocardiography.
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Conclusion & Impact:PEXS may be regarded as a risk factor for cardiovascular and cerebrovascular events.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To assess the aortic root function in patients with pseudoexfoliation syndrome (PEXS). Methods: In this case- controlled observational study, aortic root function in 31 PEXS patients (mean age 71±9 years) and 29 controls of similar ages (mean age 69±9 years) were evaluated by M-mode transthoracic echocardiography. Aortic cross-sectional compliance (CSC), Peterson’s elastic modulus (index beta), aortic stiffness index (ASI) and aortic root distensibility (ARD) were calculated by M-mode echocardiography to evaluate the aortic root function. The findings of two groups of patients were compared by Mann-Whitney U test. Results: The CSC and ARD were significantly decreased in patients with PEXS. The CSC was 12.2±6.3 cm2/mmHg in patients with PEXS and 17.5±11.6 cm2/mmHg in the control group (p=0.015). The ARD was 1.56±0.80 cm2/dyne in patients with PEXS and 2.23±1.48 cm2/dyne in the control group (p=0.021). The other two indices of aortic root function were not significantly different between the two groups. Conclusion: Aortic root function decreases in patients with PEXS. PEXS may be regarded as a risk factor for cardiovascular and cerebrovascular events.

Özet

Amaç: Psödoeksfoliyasyon sendromu olan hastalarda aorta kökü fonksiyonlarını değerlendirmek. Yöntemler: Bu gözlemsel, vaka kontrollü çalışmada, psödoeksfoliyasyon sendromu (PES) olan 31 hasta (ortalama yaş: 71±9 yıl) ve benzer yaştaki 29 kontrol (ortalama yaş±SD: 69±9 yıl) olguda aorta kök fonksiyonu değerlendirmesi için M-mod transtorasik ekokardiyografi yapıldı. Aorta kök fonksiyonu değerlendirmesinde, M-mod ekokardiyografi ile aortanın kesitsel kompliansı (AKK), Peterson elastik modülü (indeks beta), aorta sertlik indeksi (ASİ) ve aort kökü gerilme kapasitesi (AKG) hesaplandı. Bu iki grup hastanın bulguları, Mann-Whitney U testi ile karşılaştırıldı. Bulgular: AKK ve AKG, psödoeksfoliyasyon sendromu olan hastalarda belirgin derecede azalmıştı. AKK, psödoeksfoliyasyonlu hastalarda 12.2±6.3 cm2/mmHg iken, kontrol grupta17.5±11.6 cm2/mmHg olarak bulundu (p=0.015). AKG, psödoeksfoliyasyon sendromu olan hastalarda 1.56±0.80 cm2/dyne olarak, kontrol grubunda ise 2.23±1.48 cm2/dyne olarak bulundu (p=0.021). Aorta kök fonksiyonu değerlendirmesinde iki grup arasında hesaplanan diğer iki indeks açısından belirgin fark bulunamadı. Sonuç: Psödoeksfoliyasyon sendromu olan hastalarda aorta kök fonksiyonu azalmıştır. PES, kardiyovasküler ve serebrovasküler olaylar için bir risk faktörü olarak değerlendirilebilir.

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Cite This Article

BORAZAN, M., ALPASLAN, M., KARALEZLİ, A., EKİNCİ, B. K., MÜDERRİSOĞLU, İ. H. (2022). Psödoeksfoliyasyon sendromunun yeni bir sistemik göstergesi olarak azalmış aorta kökü esnekliği: Gözlemsel bir çalışma. Anadolu Kardiyoloji Dergisi, Cilt: 12 - Sayı: 6, 483–487. https://ajindex.com/articles/436413

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