SavedAdd your journal

Journals / Anadolu Kardiyoloji Dergisi / 2012 / Cilt: 12 - Sayı: 1

Aşikar kardiyovasküler hastalığı olmayanlarda koroner arter kalsifikasyonu ile ortalama trombosit hacmi arasındaki ilişki: Gözlemsel bir çalışma

Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study

Mustafa Tarık AĞAÇ
Zeydin ACAR
Selim KUL
Ayça KORKMAZ ATA
Muslihittin Emre ERKUŞ
Şükrü ÇELİK
Levent KORKMAZ
Abdulkadir KIRIŞ
Ali Rıza AKYÜZ
Pages
35–39
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There was a significant relation between CAC and MPV (r=0.24, p=0.02), age (r=0.32, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Platelets have an important role in the pathogenesis of atherothrombosis.
📊
Key Findings & Data:Methods: In this observational study, we enrolled 259 participants with at least one cardiac risk factor but with unknown cardiovascular disease.
💡
Conclusion & Impact:There was a significant relation between CAC and MPV (r=0.24, p=0.02), age (r=0.32, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Platelets have an important role in the pathogenesis of atherothrombosis. It has been shown that platelet size measured by mean platelet volume (MPV), correlates with their reactivity and is still regarded as an easy, useful tool for indirect monitoring of platelet activity in different situations. Coronary artery calcification (CAC) has long been known to occur as a part of the atherosclerotic process. The aim of this study was to determine whether an association exists between MPV and CAC. Methods: In this observational study, we enrolled 259 participants with at least one cardiac risk factor but with unknown cardiovascular disease. Coronary calcification was assessed by multislice computerized tomography and MPV was measured in a blood sample collected in EDTA tubes. Statistical analysis was performed using Kruskal-Wallis, Chi-square, correlation tests and multiple regression analysis. Results: Calcium scores ranged from 0 to 735. There was a significant relation between CAC and MPV (r=0.24, p=0.02), age (r=0.32, p

Özet

dolaylı bir parametredir. Koroner arter kalsifikasyonunun (KAK) aterosklerotik proçesin bir parçası olduğu uzun zamandır bilinmektedir. Bu çalışmamızda aşikar kardiyovasküler hastalığı olmayan hastalarda KAK ile OTH arasındaki ilişkiyi inceledik. Yöntemler: Bu gözlemsel çalışmada, bilinen kardiyovasküler hastalığı olmayan ve en az bir kardiyovasküler riski olan 259 hasta çalışmaya alındı. KAK çok kesitli tomografi ile değerlendirildi. OTH ise etilen diamin tetra asetik asit (EDTA)’li tüplere alınan kanda ölçüldü. İstatistiksel analiz Kruskal-Wallis, Ki-kare, korelasyon testleri ve çoklu regresyon analiz ile yapıldı. Bulgular: Kalsiyum skoru 0 ile 735 arasında idi. Tek yönlü analizde KAK ile OTH (r=0.24, p=0.02), yaş (r=0.32, p

🔖

Cite This Article

AĞAÇ, M. T., ACAR, Z., KUL, S., ATA, A. K., ERKUŞ, M. E., ÇELİK, Ş., KORKMAZ, L., KIRIŞ, A., AKYÜZ, A. R. (2022). Aşikar kardiyovasküler hastalığı olmayanlarda koroner arter kalsifikasyonu ile ortalama trombosit hacmi arasındaki ilişki: Gözlemsel bir çalışma. Anadolu Kardiyoloji Dergisi, Cilt: 12 - Sayı: 1, 35–39. https://ajindex.com/articles/436355

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Massberg S, Schulz C, Gawaz M. Role of platelets in the pathophysiology of acute coronary syndrome. Semin Vasc Med 2003
  2. [CrosRef] 2. Thombson CB, Eaton K, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982
  3. [CrosRef] 3. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003
  4. [CrosRef] 4. Ardehali R, Nasir K, Kolandaivelu A, Budoff MJ, Blumenthal RS. Screening patients for subclinical atherosclerosis with noncontrast cardiac CT. Atherosclerosis 2007
  5. [CrosRef] 5. Rumberger JA. Using noncontrast cardiac CT and coronary artery calcification measurements for cardiovascular risk assessment and management in asymptomatic adults. Vasc Health Risk Manag 2010
  6. [CrosRef] 6. Raggi P. Role of electron-beam computed tomography and nuclear stress testing in cardiovascular risk assessment. Am J Cardiol 2005
  7. 96 Suppl:20J-7J. [CrosRef] 7. Taylor AJ, Feuerstein I, Wong H, BarkoW, Brazaitis M, O’Malley PG. Do conventional risk factors predict subclinical coronary artery disease? Results from the Prospective Army Coronary Calcium Project. Am Heart J 2001
  8. [CrosRef] 8. Kondos GT, Hoff JA, Sevrukov A, Daviglus ML, Garside DB, Devries SS, et al. Electron-beam tomography coronary artery calcium and cardiac events: a 37-month follow-up of 5635 initially asymptomatic low- to intermediate-risk adults. Circulation 2003
  9. [CrosRef] 9. Jung DH, Lee HR, Lee YJ, Kim JK, Park BJ, Shim JY. The association between coronary artery calcification and mean platelet volume in the general population. Platelets 2011 Jun 30. [Epub ahead of print] 10. Janowitz WR. CT imaging of coronary artery calcium as an indicator of atherosclerotic disease: an overview. J Thorac Imaging 2001
  10. [CrosRef] 11. Redberg RF, Rifai N, Gee L, Ridker PM. Lack of association of C-reactive protein and coronary calcium by electron beam computed tomography in postmenopausal women: implications for coronary artery disease screening. J Am Coll Cardiol 2000
  11. [CrosRef] 12. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Circulation 2002
  12. Greenland P, Bonow RO, Brundage