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Journals / Anadolu Kardiyoloji Dergisi / 2011 / Cilt: 11 - Sayı: 1

Koroner arter hastalığı olan hastalarda miyokardiyal yeniden şekillenme ve iskemiye bir yıllık lovastatin tedavisinin etkisi

Influence of one-year treatment with lovastatin on myocardial remodeling and ischemia in patients with coronary artery disease

Olga LUNEGOVA
Irina GOTFRID
Aybek MIRRAKHIMOV
Nailya DAVYDOVA
Cholpon MOLDOKEEVA
Erkin MIRRAKHIMOV
Alina KERIMKULOVA
Aygul NORUZBAEVA
Pages
16–21
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: In the 1st group there was an improvement of lipid spectrum (p

📌 3 Key Takeaways

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Objective & Hypothesis:Emerging evidence assumes that statins have a benefit to influence the myocardial remodeling and ischemia in patients with coronary artery disease (CAD).
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Key Findings & Data:Methods: This randomized prospective study consisted of 83 patients (46 males; mean age 54.3±6.5 years) with CAD and dyslipidemia.
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Conclusion & Impact:Results: In the 1st group there was an improvement of lipid spectrum (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Emerging evidence assumes that statins have a benefit to influence the myocardial remodeling and ischemia in patients with coronary artery disease (CAD). Our aim was to investigate the possible and direct favorable effects of lovastatin on left ventricular (LV) systolic, diastolic function and myocardial ischemia in patients with CAD. Methods: This randomized prospective study consisted of 83 patients (46 males; mean age 54.3±6.5 years) with CAD and dyslipidemia. All patients were randomized to following groups: the 1st group (n=44) received lovastatin (20-60 mg/day), hypolipidemic diet and physical training; the 2nd group (n=39) - hypolipidemic diet and physical training. Lipid spectrum, Doppler-echocardiography, bicycle exercise test and 24-hour ambulatory electrocardiographic monitoring were done at baseline and were repeated after 12 months of treatment. The data were analyzed by using the paired and unpaired Student's t-tests. Results: In the 1st group there was an improvement of lipid spectrum (p

Özet

Koroner arter hastalığı (KAH) ve dislipidemili hastalardaki iskemi ve miyokart yeniden şekillenme üzerine statinlerin yararlı etkileri olduğu kanıtlanmıştır. Amacımız, lovastatinin sol ventrikül (SV) sistolik ve diyastolik fonksiyonları ile miyokart iskemisi üzerine olası ve doğrudan yararlı etkilerini araştırmaktı. Yöntemler: Bu randomize prospektif çalışma, koroner arter ve dislipidemi hastalığı olan 83 hastadan (46 erkek; ortalama yaş, 54.3±6.5 yıl) oluşmaktadır. Bütün hastalar, gruplara randomizeydi: 1. grup (N= 44), 20-60 mg/gün lovastatin aldı, hipolipidemik diyet ve beden eğitimi uygulandı; 2. grup (N=39) - hipolipidemik diyet ve beden eğitimi uygulandı. Başlangıçta lipit spektrumu, Doppler ekokardiyografi, bisiklet egzersiz testi ve 24-saat ambulatuvar elektrokardiyogram izlemesi, yapıldı ve 12 aydan sonra tekrarlandı. Veriler, eşleştirilmiş ve eşleştirilmemiş Student's t-tests kullanarak analiz edildi. Bulgular: Birinci grupta, karaciğer transaminazlarında önemli değişiklikler ve diğer yan etkiler olmaksızın lipit spektrumunda (p

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Cite This Article

LUNEGOVA, O., GOTFRID, I., MIRRAKHIMOV, A., DAVYDOVA, N., MOLDOKEEVA, C., MIRRAKHIMOV, E., KERIMKULOVA, A., NORUZBAEVA, A. (2022). Koroner arter hastalığı olan hastalarda miyokardiyal yeniden şekillenme ve iskemiye bir yıllık lovastatin tedavisinin etkisi. Anadolu Kardiyoloji Dergisi, Cilt: 11 - Sayı: 1, 16–21. https://ajindex.com/articles/436287

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