Kırgızistan ın yerli halkında lipitler ve leptin düzeyi

Objective & Hypothesis:Objectives: A possible link between obesity and impaired lipid metabolism is leptin, the 167-amino acid protein, secret- ed by adipocytes.

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Key Findings & Data:Study design: The study included 322 ethnic Kyrgyz (145 males, 177 females) aged ≥30 years, living in Kyrgyzstan.

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Conclusion & Impact:Conclusion: Leptin is associated with BMI, WC and TG in both sexes of Kyrgyz and with TC in Kyrgyz males.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objectives: A possible link between obesity and impaired lipid metabolism is leptin, the 167-amino acid protein, secret- ed by adipocytes. The content of leptin in the body is closely associated with body mass index (BMI). Data obtained from studies on the association of leptin with dyslipidemia are con- tradictory. The level of leptin has not been studied in the ethnic Kyrgyz population previously. The purpose of this study was to investigate the relationship between leptin and lipid param- eters in a group of ethnic Kyrgyz. Study design: The study included 322 ethnic Kyrgyz (145 males, 177 females) aged ≥30 years, living in Kyrgyzstan. Measurement of anthropometric parameters (height, weight, waist circumference [WC], hip circumference [HC]) and blood pressure (BP) was done. Laboratory tests included blood glu- cose (fasting) in plasma, lipid profile (total cholesterol [TC], triglycerides [TG], high-density lipoprotein [HDL] cholesterol, low-density lipoprotein [LDL] cholesterol), and serum leptin. Results: Leptin was positively correlated with BMI, WC and TG in both sexes and with TC in males. Conclusion: Leptin is associated with BMI, WC and TG in both sexes of Kyrgyz and with TC in Kyrgyz males.

Özet

Amaç: Adipositler tarafından salgılanan 167 amino asitli protein olan leptin obezite ile bozulmuş lipit metabolizması arasındaki olası bağlantıyı oluşturur. Vücutta leptinin içeriği beden kütle indeksiyle (BKİ) yakından ilişkilidir. Leptinin dislipidemiyle ilişkisi konusundaki çalışmalardan elde edilen veriler çelişkilidir. Kırgız halkında leptin düzeyi daha önce araştırılmamıştır. Bu çalışmanın amacı Kırgız ırkında leptin ile lipit parametreleri arasındaki ilişkiyi araştırmaktır.Çalışma planı: Çalışmaya Kırgızistanda yaşayan ≥30 yaşlarında Kırgız ırkından 322 kişi (145 erkek, 177 kadın) alındı. Antropometrik parametreler [boy, kilo, bel çevresi (BÇ), kalça çevresi (KÇ)] ve kan basıncı (KB) ölçüldü. Laboratuvar testlerinden açlık kan şekeri (AKŞ), lipit profili [total kolesterol (TK), trigliseritler (TG), yüksek yoğunluklu lipoprotein (YYL) kolesterol, düşük yoğunluklu kolesterol (DYL) ve serum leptin ölçüldü.Bulgular: Serum leptin, her iki cinste BKİ, BÇ, TG ve erkeklerde TK ile pozitif korelasyon göstermektedir.Sonuç: Leptin, Kırgızlarda her iki cinste BKİ, BÇ ve TK, erkeklerde TK ile ilişkilidir.

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Cite This Article

LUNEGOVA, O., MİRRAKHİMOV, E., KERİMKULOVA, A., MİRRAKHİMOV, A., ALİBAEVA, N., NABİEV, M. (2022). Kırgızistan ın yerli halkında lipitler ve leptin düzeyi. Türk Kardiyoloji Derneği Arşivi, Cilt: 42 - Sayı: 3, 253–258. https://ajindex.com/articles/602445

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