AI Summary & Key Takeaways
AI InsightOur resultsdo not support accelerated atherosclerosis in IBS population (Anadolu
📌 3 Key Takeaways
Abstract
Objective: Irritable bowel syndrome (IBS), a subgroup of functional somatic disorders, may be associated with autonomic dysfunction (AD).Heart rate variability (HRV), a measure of autonomic dysfunction, may predict survival. The aim of this study was to investigate the effect of IBSon HRV parameters, carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) as surrogates of AD, subclinicalatherosclerosis and arterial stiffness, respectively.Methods: Our study was cross-sectional and observational. Thirty consecutive patients with IBS and 30 control participants underwent 24-hourHolter monitoring, cf-PWV assessment and CIMT measurement. The diagnosis of IBS was based on Rome III criteria. There were 24 patientswith IBS-Constipation (80%), 4 patients with IBS-Diarrhea (13.3%), and 2 patients with IBS-Mixed (6.7%) in IBS group. Student t-test and χ2 testwere utilized in order to compare continuous and categorical variables between two groups, respectively.Results: Biochemical parameters did not differ between groups except for slightly increased creatinine in patients with IBS. cf-PWV and CIMTvalues were similar between groups. SDNN index and RMSSD were significantly impaired in patients with IBS compared to controls. Frequencyanalyses revealed lower LF, HF, and VLF in subjects with IBS.Conclusion: We demonstrated decreased parasympathetic modulation in patients with constipation predominant IBS. However, we could notdemonstrate any changes in vascular structure and functions measured by carotid intima-media thickness and pulse wave velocity. Our resultsdo not support accelerated atherosclerosis in IBS population (Anadolu