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Journals / Anadolu Kardiyoloji Dergisi / 2014 / Cilt: 14 - Sayı: 1

Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

Neslihan ÇOBAN
Altan ONAT
Evrim BAYRAK KÖMÜRCÜ
Çağrı GÜLEÇ
Günay CAN
Nihan Erginel- ÜNALTUNA
Pages
18–25
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In men, while homozygosity of the K allele was associated with increased plasma low-density lipoprotein cholesterol (LDL-C) (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: ATP binding cassette transporter A1 (ABCA1) controls the reverse cholesterol transport.
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Key Findings & Data:Some ABCA1 variants are correlated with serum high-density lipoprotein cholesterol (HDL-C) and other lipid concentrations.
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Conclusion & Impact:In men, while homozygosity of the K allele was associated with increased plasma low-density lipoprotein cholesterol (LDL-C) (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: ATP binding cassette transporter A1 (ABCA1) controls the reverse cholesterol transport. Some ABCA1 variants are correlated with serum high-density lipoprotein cholesterol (HDL-C) and other lipid concentrations. We aimed to explore the relationship of ABCA1 gene with both the lipid profile and coronary heart disease (CHD) risk. Methods: Selected 627 individuals of the Turkish Adult Risk Factor Study were genotyped for ABCA1 R219K polymorphism using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method. Student's t-test, one-way ANOVA, Chi-square test, linear and logistic regression was used for statistical analysis. Results: We demonstrated a gender-specific effect of the R219K polymorphism on plasma lipids and CHD. In men, while homozygosity of the K allele was associated with increased plasma low-density lipoprotein cholesterol (LDL-C) (p

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Cite This Article

ÇOBAN, N., ONAT, A., KÖMÜRCÜ, E. B., GÜLEÇ, Ç., CAN, G., ÜNALTUNA, N. E. (2022). Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. Anadolu Kardiyoloji Dergisi, Cilt: 14 - Sayı: 1, 18–25. https://ajindex.com/articles/436040

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