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Journals / Türk Kardiyoloji Derneği Arşivi / 2019 / Cilt: 47 - Sayı: 1

Macrophage migration inhibitory factor (MIF) gene -173 G>C polymorphism and its relationship to coronary artery disease and type 2 diabetes

Makrofaj migrasyon inhibitör faktör (MIF) geni -173 G>C polimorfizminin koroner arter hastalığı ve tip 2 diyabet ile ilişkisi

Aycan Fahri Erkan
Berkay Ekici
Eren Vurgun
Neslihan Çoban
Maide Kaşit
Nihan Erginel Ünaltuna
Pages
29–37
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the same subgroups, carriers of the MIF common allele in the control group demonstrated a protection against developing T2DM compared with noncarriers (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Recent studies indicate that macrophage migration inhibitory factor (MIF) is a potent proinflammatory cytokine which mediates the inflammatory process during atherosclerosis.
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Key Findings & Data:The purpose of the study was to investigate an association between MIF gene polymorphism and type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) in the Turkish population.
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Conclusion & Impact:In the same subgroups, carriers of the MIF common allele in the control group demonstrated a protection against developing T2DM compared with noncarriers (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Recent studies indicate that macrophage migration inhibitory factor (MIF) is a potent proinflammatory cytokine which mediates the inflammatory process during atherosclerosis. The purpose of the study was to investigate an association between MIF gene polymorphism and type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) in the Turkish population. Methods: A total of 139 unselected Turkish patients with significant CAD (coronary lesion with 50–100% stenosis) and 120 control participants (coronary lesion with 0.05). In the same subgroups, carriers of the MIF common allele in the control group demonstrated a protection against developing T2DM compared with noncarriers (p

Özet

Amaç: Yapılan son çalışmalar, makrofaj migrasyon inhibitörfaktörünün (MIF) ateroskleroz sırasında enflamatuvar sürecearacılık eden güçlü bir proenflamatuvar sitokin olduğunu göstermektedir.Bu çalışmadaki amacımız, koroner arter hastalığı(KAH) olan ve KAH olmayan bireylerde MIF gen polimorfizmive tip 2 diyabetes mellitus (T2DM) arasındaki ilişkiyi araştırmaktır.Yöntemler: Seçilmemiş 259 Türk hasta, anlamlı KAH (%50–100 stenoz bulunan koroner lezyon) ve kontrol (0.05). Buna karşılık, aynı altgruplarda, taşıyıcı olmayanlar ile karşılaştırıldığında, MIF genirs755622 polimorfizmi yaygın allel taşıyıcıları, kontrol grubundakiT2DM hastalığını geliştirmeye karşı bir koruma göstermektedir(p

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Cite This Article

Erkan, A. F., Ekici, B., Vurgun, E., Çoban, N., Kaşit, M., Ünaltuna, N. E. (2022). Macrophage migration inhibitory factor (MIF) gene -173 G>C polymorphism and its relationship to coronary artery disease and type 2 diabetes. Türk Kardiyoloji Derneği Arşivi, Cilt: 47 - Sayı: 1, 29–37. https://ajindex.com/articles/632031

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