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Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2001 / Cilt: 2 - Sayı: 1

Squamous differentiation in transitional bladder carcinomas and its correlation with grade, stage, DNA content, and prognosis

Transizyonel hücreli mesane karsinomlarında skuamöz diferansiyasyonunun, evre, derece, DNA içeriği ve prognozla ilişkisi

Elif SELEK
Cem YENİYOL
Füruzan KACAR
Sedat ÇİÇEK
Pages
17–20
Publication Date
2022-10-10
DOI
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Conclucion: While no direct correlation between squamous differentiation and survival could be demonstrated, since there was a significant relation between squamous differentiation and stage (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: In this study, the correlation of squamous differentiation with tumor grade, stage, DNA content and prognosis was investigated in tansitional cell carcinomas.
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Key Findings & Data:Results: Only 2 of 16 cases of grade I transitional cell carcinoma showed squamous differentiation.
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Conclusion & Impact:Conclucion: While no direct correlation between squamous differentiation and survival could be demonstrated, since there was a significant relation between squamous differentiation and stage (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aims: In this study, the correlation of squamous differentiation with tumor grade, stage, DNA content and prognosis was investigated in tansitional cell carcinomas. Materials and Methods: Cases of transitional cell carcinomas with squamous differentiation were histologically graded, (Mostofi), clinically staged (AJCC), and DNA content of tumor cells were determined with flow cytometry. These data were correlated with prognosis using Pearson chi square, Pearson correlation analysis and Kaplan-Meier analysis. Results: Only 2 of 16 cases of grade I transitional cell carcinoma showed squamous differentiation. Among grade III cases 8 of 14 showed squamous differentiation, while 6 cases didn't. Only 3 of 17 stage I cases showed squamous differentiation; 14 cases didn't. Five of 11 stage II cases showed squamous differentiation; 6 cases didn't. Two out of 2 cases of stage III transitionel cell carcinoma showed squamous differentiation. Out of 15 cases which had diploidDNAcontent, only 1 showed squamous differentiation while 14 didn't. Among 15 cases with aneuploidDNAcontent, 9 had squamous differentiation; 6 cases didn't. During the 4 years follow up period, only 1 of 20 cases of transitional cell carcinoma without squamous differentiation were fatal, while three of 10 cases with squamous differentiation were fatal. Conclucion: While no direct correlation between squamous differentiation and survival could be demonstrated, since there was a significant relation between squamous differentiation and stage (p

Özet

Amaç: Bu çalışmada transizyonel hücreli mesane karsinomlarında (THK) izlenen skuamöz diferansiyasyonun evre, derece, DNA içeriği ve prognozla ilişkisi araştırılmıştır. Gereç Yöntem: Skuamöz diferansiyasyonlu olgularda histopatolojik derecelendirme (Mostofi), evreleme (AJCC), tümör hücrelerinde akımsitometrisi (flowcytometry) ile çalışılan DNA içerikleri, klinik izlem ve bunların biribirleri ile ilişkileri tanımlayıcı istatistik (anterior ortalama, standart hata, standart sapma) ve analitik istatistik yöntemler (Pearson chi square, Pearson bağıntı analizi, Kaplan-Meier) kullanılarak araştırılmıştır. Bulgular: Derece I olan 16 olgudan 14'ünde skuamöz diferansiyasyon yokken, 2'sinde mevcuttu. Derece III olan olguların 6'sında skuamöz diferansiyasyon izlenmezken 8'inde izlendi. Evre I olan 17 olgudan 14'ünde skuamöz diferansiyasyon yokken, 3'ünde vardı. Evre II olan 11 olgudan 6'sında skuamöz diferansiyasyon yokken, 5'inde vardı. Evre III olan 2 olgunun 2'sinde de skuamöz diferansiyasyon izlendi. DNA içeriği diploid olan 15 olgudan 14'ünde skuamöz diferansiyasyon yokken, 1'inde vardı. Anöploid DNA içerikli 15 olgudan 6'sında skuamöz diferansiyasyon yokken, 9'unda izlendi. Dört yıllık izlem süresi boyunca skuamöz diferansiyasyon olmayan 20 THK'lu olgudan sadece birisi ölmüştür. Skuamöz diferansiyasyon izlenen 10 olgudan 3'ü ölmüştür. Sonuç: Skuamöz diferansiyasyon, yaşam süresi ile doğrudan ilişkili bulunmamakla birlikte prognostik kriterlerden olan evre (p

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Cite This Article

SELEK, E., YENİYOL, C., KACAR, F., ÇİÇEK, S. (2022). Squamous differentiation in transitional bladder carcinomas and its correlation with grade, stage, DNA content, and prognosis. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi, Cilt: 2 - Sayı: 1, 17–20. https://ajindex.com/articles/429148

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