Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2001 / Cilt: 2 - Sayı: 2

Is neurogenous hyperplasia a cause of appendiceal obliteration? (A retrospective study of 1397 cases)

Nörojenik hiperplazi appendiks obliterasyonu nedeni midir? (1397 olgunun retrospektif incelemesi)

Pages
15–18
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We emphasise that neurogenous hyperplasia in obliterated appendices is a rather common entity, and that most cases of socalled fibrous obliteration actually represent neurogenic appendicopathy.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: in this study the presence of neural tissue components was investigated in appendectomy specimens with an obliterated appendix.
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Key Findings & Data:Material and method: Retrospective analysis of 1379 consecutive routine appendectomy specimens revealed 66 cases as "obliterated appendix" (an incidence of 4,2%).
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Conclusion & Impact:Conclusion: We emphasise that neurogenous hyperplasia in obliterated appendices is a rather common entity, and that most cases of socalled fibrous obliteration actually represent neurogenic appendicopathy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: in this study the presence of neural tissue components was investigated in appendectomy specimens with an obliterated appendix. Relationship of the neural tissue presence with other appendical lesions such as carcinoid tumors and acute appendicitis was also evaluated. Material and method: Retrospective analysis of 1379 consecutive routine appendectomy specimens revealed 66 cases as "obliterated appendix" (an incidence of 4,2%). Only 38 appropriate cases have been included in this study. Results: By light microscopy, obliteration was located centrally in the appendix without nodule formation. Loose proliferation of spindle cells, usually in a myxoid background, and with entrapped fat tissue was frequently observed. The spindle cells were positive for S-100 protein in 18 of 3 8 cases (47,3 %). Conclusion: We emphasise that neurogenous hyperplasia in obliterated appendices is a rather common entity, and that most cases of socalled fibrous obliteration actually represent neurogenic appendicopathy.

Özet

Amaç: Bu çalışmada çoğu akut appendisit ön tanısıyla çıkartılan appendektomi örneklerinde saptanan oblitere appendikslerdeki nöral doku komponentinin varlığı araştırılmış ve akut appendisit, karsinoid tümör gibi diğer appendiks lezyonlarıyla ilişkisi irdelenmiştir. Gereç ve yöntem: Retrospektif olarak taranan 1397 rutin appendektomi materyalinde "oblitere appendiks" tanısı almış 66 olgu bulundu. Ancak bunlardan uygun nitelikli 38 tanesi çalışma kapsamına alındı. Bu olguların hematoksileneosin ve Masson trikrom boyalı preparatları incelendi. Ayrıca materyallerde immünhistokimyasal olarak S-100 protein reaktivitesi araştırıldı. Bulgular: Işık mikroskopik düzeyde appendiks lümenlerinde nodul yapmaksızın gevşek dizilimli iğsi hücrelerin proliferasyonuyla oluşmuş obstrüksiyon izlendi. Miksoid zemin ve arada kısılı yağ dokusu da sıklıkla mevcuttu. 38 olgunun 18'inde( % 47,3) iğsi hücrelerde S-100 protein immün reaktivitesi gözlendi. Sonuç: Bu çalışmada oblitere appendikslerde nöral hiperplazinin oldukça sık görülen bir antite olduğu ve çoğu kez fıbröz obliterasyon olarak nitelenen lezyonun gerçekte nörojenik kökenli bir gelişim olabileceği vurgulanmaya çalışıldı.

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Cite This Article

TUNAKAN, M., ÜSTÜN, M., ÇENGEL, G., DİNİZ, G. (2022). Is neurogenous hyperplasia a cause of appendiceal obliteration? (A retrospective study of 1397 cases). Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi, Cilt: 2 - Sayı: 2, 15–18. https://ajindex.com/articles/429138

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References (1)

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