AI Summary & Key Takeaways
AI InsightConclusions: In mentally retarded children, intramuscular midazolam injection followed by propofol resulted in better cooperation and sedation.
📌 3 Key Takeaways
Abstract
Background and objective: The aim of this investigation was to study the effects of propofol and midazolam followed by propofol on children who had epilepsy and mental retardation, and could not be sufficiently sedated with orally administered chloral hydrate and cardiac cocktail for Magnetic Resonance Imaging. Methods: We have compared the sedation levels using the Ramsay Sedation Score maintained by the infusion of either propofol alone or followed by intramuscular administration of midazolam in 23 neurologically debilitated children aged 4-10 years undergoing Magnetic Resonance Imaging. The patients received a slow intravenous bolus injection of 2 mg kg propofol followed by continuous infusion, with (n= 11 ) or without (n= 12) midazolam (0.2 mg kg ) sedation given intramuscularly 15 minutes before the Magnetic Resonance Imaging._Mann Whitney U, Chi square and Fisher's exact tests were used for the statistical analysis testing, p< 0.05 were considered to have statistical significance. Results: Sedation level was higher in midazolam plus propofol group than propofol group immediately before intravenous cannulation, and during Magnetic Resonance Imaging (p = 0.002; p = 0.001 respectively). In both groups, the respiratory rate decreased significantly following the injection of propofol (p =0.025 and p= 0.021 ). Patients in the propofol group recovered rapidly. At the end of the first hour, the recovery scores of both groups were similar. In the dose scheme we have used, propofol produced sedation during Magnetic Resonance Imaging. Conclusions: In mentally retarded children, intramuscular midazolam injection followed by propofol resulted in better cooperation and sedation.
Özet
Amaç: Manyetik rezonans görüntüleme için oral kloral hidrat veya kardiyolojik kokteyl ile yeterli sedasyon sağlanamayan mental retardasyonu ve epilepsisi olan çocuklarda propofol ile midazolamı takiben uygulanan propofol sedasyonu bulgularını karşılaştırmaktır. Yöntem: Manyetik rezonans görüntüleme yapılan 4-10 yaş arası nörolojik bozukluğu olan 23 çocukta propofolün tek başına veya intramuskuler midazolamdan sonra uygulandığında sağlanan sedasyon seviyeleri Ramsay Sedasyon Skoruna göre karşılaştırıldı. Manyetik rezonans görüntülemeden 15 dakika önce hastalara intramuskuler 0.2 mg kg midazolam sedasyonu yapılarak (n=11 ) veya yapılmadan (n=12) 2 mg kg propofol intravenöz yavaş bolusu takiben sürekli infüzyon şeklinde uygulandı (n = 12). İstatistiksel değerlendirmede Mann Whitney U, Ki kare ve Fisher exact testleri kullanıldı, p