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Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2005 / Cilt: 6 - Sayı: 2

Effects of topical mometasone furoate therapy on local and systemic macrophage migration inhibitory factor levels in allergic rhinitis patients

Alerjik rinitli hastalarda topikal mometazon furoat tedavisinin makrofaj migrasyon inhibitör faktör'ün lokal ve sistemik düzeyleri üzerine etkisi

Sema BAŞAK
Tülay KAVAK
Leyla Didem KOZACI
Fürüzan DÖĞER
Didem EVCİ
Hülya EYİGÖR
Ian C CHIKANZA
Pages
23–27
Publication Date
2022-10-10
DOI
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⚡ TL;DR(Too Long; Didn't Read)

MIF levels in serum and nasal lavage were measured by anenzyme-linked immunosorbent assay.Results: Topical glucocorticoid treatment significantly inhibited total symptom score (TSS) (16,95 4,27 and 9,24 3,38, respectively, p

📌 3 Key Takeaways

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Objective & Hypothesis:Background: In this study we aimed to investigate the systemic and local levels of macrophage migration inhibitory factor (MIF) before and after topically applied mometasone furoate therapy in patients with allergic rhinitis.
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Key Findings & Data:Material and Methods: Twenty-two patients (8males and 14 females; median of 46 years ranging, from17 to 68 years) with AR were subjects of this study.
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Conclusion & Impact:MIF levels in serum and nasal lavage were measured by anenzyme-linked immunosorbent assay.Results: Topical glucocorticoid treatment significantly inhibited total symptom score (TSS) (16,95 4,27 and 9,24 3,38, respectively, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: In this study we aimed to investigate the systemic and local levels of macrophage migration inhibitory factor (MIF) before and after topically applied mometasone furoate therapy in patients with allergic rhinitis. We also investigated the effects of therapyon local eosinophil accumulation. Material and Methods: Twenty-two patients (8males and 14 females; median of 46 years ranging, from17 to 68 years) with AR were subjects of this study. Percentages of eosinophils in nasal smears were calculated. MIF levels in serum and nasal lavage were measured by anenzyme-linked immunosorbent assay.Results: Topical glucocorticoid treatment significantly inhibited total symptom score (TSS) (16,95 4,27 and 9,24 3,38, respectively, p

Özet

Amaç: Bu çalışmada mometazon furoat nazal sprey (MFNS) ile tedavi ettiğimiz alerjik rinitli hastalarda tedavi öncesi (TÖ) / tedavi sonrası (TS) serumda ve nazal lavaj sıvılarında makrofaj migrasyon inhibitör faktör (MİF) düzeylerini araştırdık. Ayrıca, tedavinin nazal mukozadaki eozinofil düzeyine etkilerini irdeledik. Gereç ve Yöntem: İlk muayene sırasında alerjik rinit yakınmalarının en az ikisine sahip olan 22 hastanın semptomları skorlandı, muayene bulguları kaydedildi; serumda ve nazal lavaj sıvısında MİF değerleri saptandı. Hastalara günde bir kez 100 g MFNS (Nasonex®) başlandı. TS dördüncü haftada semptomlar ve muayene bulguları yeniden değerlendirildi, nazal lavaj/serum MİF değerleri ELISA metodu ile ölçüldü. Nazal mukoza impresyon sitolojisi materyallerinde eozinofillerin diğer hücrelere göre oranları hesaplandı.Bulgular:TÖ/TS nazal lavaj MİF ortalaması (sırasıyla 503,53 294,50 pg/ml ve 1422.35 1097,98 pg/ml, P0.05) bulundu. Nazal mukozanın impresyon sitolojisinde eozinofil yüzdesi TÖ ve TS, sırasıyla 51.86 28,94 ve 25.64 23,60 idi. Eozinofil yüzdeleri arasındaki fark istatistiksel olarak anlamlıydı (p

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Cite This Article

BAŞAK, S., KAVAK, T., KOZACI, L. D., DÖĞER, F., EVCİ, D., EYİGÖR, H., CHIKANZA, I. C. (2022). Effects of topical mometasone furoate therapy on local and systemic macrophage migration inhibitory factor levels in allergic rhinitis patients. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi, Cilt: 6 - Sayı: 2, 23–27. https://ajindex.com/articles/429055

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