SavedAdd your journal

Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2008 / Cilt: 9 - Sayı: 3

Cell cycle and cancer

Hücre siklusu ve kanser

Hülya CABADAK
Pages
51–61
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Tumor supression of growth arrest, DNA repair and apoptosis, are all critical pathways in the development of cancers.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Proliferation and cell cycle progression are linked to the expression of genes associated with growth control.
📊
Key Findings & Data:The eucaryotic cell cycle consists of an M (mitotic) phase, a G1 phase, the S phase and G2 phase.
💡
Conclusion & Impact:Tumor supression of growth arrest, DNA repair and apoptosis, are all critical pathways in the development of cancers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Proliferation and cell cycle progression are linked to the expression of genes associated with growth control. The eucaryotic cell cycle consists of an M (mitotic) phase, a G1 phase, the S phase and G2 phase. Non-dividing cells exist at G0. Cell cycle is regulated by several critical cell cycle check points These are G1-S check point, G2 -M check point and metaphase-anaphase check point. Cell cycle is controlled by the cycline dependent kinases (cdk, catalytic subunit) and cyclins (cyc, regulatory subunit). Homeostasis is within a cell is regulated by the balance between proliferation, growth arrest and apopto sis. Defects in cell cycle regulation inhibit controls for cell division. Alterations of cell cycle check points might result in cancer. The interactions which control and regulate the cascade of events within cell cycle are numerous and complex. Tumor supression of growth arrest, DNA repair and apoptosis, are all critical pathways in the development of cancers.

Özet

Hücre çoğalması ve hücre siklusunun ilerlemesi büyümenin kontrolünde rolü olan genlerin ekspresyonu ile bağlantılıdır. Ökaryot hücre siklusu M (mitoz) G1, S ve G2 fazlarından oluşmaktadır. Bu süreçte hücre uyarımı ve büyüme meydana gelir veya hücre Go fazında durmaktadır. Hücre siklusunda G1-S geçişinde, G2-M geçişinde ve metafaz-anafaz geçişinde kontrol noktaları bulunmaktadır. Hücre siklusu siklin bağımlı kinazlar (cdk, katalitik altbirim) ve siklin (cyc, düzenleyici altbirim) tarafından kontrol edilmektedir. Hücre homeostazisi hücre çoğalması, büyümenin durdurulması ve apoptozis (programlı hücre ölümü) ile sürdürülmektedir. Hücre siklusu içindeki olayları düzenleyen ve kontrol eden etkileşimler çok sayıda ve komplekstir. Hücre siklusunun düzenlenmesindeki hatalar hücre bölünmesinin kontrolunun bozulmasına neden olur. Hücre siklusu kontrol noktalarında değişimler kanser gelişimine neden olabilir. Kanser gelişiminde tümör baskılayıcı fonksiyon, DNA onarımı ve apoptozis kritik yolaklardır.

🔖

Cite This Article

CABADAK, H. (2022). Cell cycle and cancer. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi, Cilt: 9 - Sayı: 3, 51–61. https://ajindex.com/articles/428994

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell JE. Molecular Cell Biology. 4th edition: WH Freeman and Co, New York, 2000. 2.Vermeulen K, VanBockstaele DR, Berneman Z N. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif 2003
  2. Guimaras CA, Linden R. Apoptosis and alternative deastyles. Eur J Biochem 2004
  3. Zong WX, Thompson CB. Necrotic death as a cell fate? Genes Dev 2006
  4. Bellamy COC. p53 and apoptosis. Br Med Bull 1996
  5. 53(3): 522-38. 6.DeVita Jr VT, Hellman S, Rosenberg SA. Cancer: principles and practice of oncolgy. 5th edition: Lippincott-Raven, Philadelphia, 1997. 7.Vermeulen K, Berneman ZN, vanBockstaele DR. Cell cycle and apoptosis. Cell Prolif 2003
  6. Öndağ Cabadak H. İnsan periferal kan ve fibroblast hücre kültürlerinin sinkronizasyonu ve sinkronize hücre kültürlerinden kromozom analizi ve karyotip hazırlanması. Yüksek Lisans Tezi, Ankara: Gazi Üniversitesi Tıp Fakültesi Tıbbi Biyoloji ve Genetik Anabilim Dalı, 1987. 9.Foster I. Cancer: A cell cycle defect. Radiography 2008
  7. Hu W, Feng Z, Teresky AK, Levine AJ. p53 regulates maternal reproduction through LIF. Nature 2007
  8. 450(7170): 721-4. 11.Kearns WG, Liu JM. Cell cycle checkpoint genes and aneuploidy: A short review. Current Genomics 2001
  9. Giacinti C, Giordano A. RB and cell cycle progression. Oncogene 2006
  10. Kelly TJ, Brown GW. Regulation of chromosome replication. Annu Rev Biochem 2000
  11. | 14.Prasanth SG, Mendez J, Prasanth KV, Stillman B. Dynamics of pre-replication complex proteins during the cell division cycle. Phil Trans R Soc Lond B 2004
  12. Flatt PM, Pietenpol JA. Mechanisms of cell-cycle checkpoints: at the cross roads of carcinogenesis and drug discovery. Drug Metab Rev 2000
  13. Sears RC,Nevins JR. Signalling networks that link cell proliferation and cell fate. J Biol Chem 2002
  14. 11617-20. 17.Stevaux O, Dyson NJ. A revised picture of the E2F transcriptional network and RB function. Curr Opin Cell Biol 2002
  15. Fearson E. Human cancer syndromes: clues to the origin and nature of cancer. Science 1997
  16. Molinari M. Cell cycle check points and their activation in human cancer. Cell Prolif 2000
  17. Cheng M, Sexl V, Sherr C, Raussel M. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kin