Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2009 / Cilt: 10 - Sayı: 2

Lipid peroxidation and antioxidant activity in normal and preeclampsic pregnancies

Normal ve preeklamptik gebelerde lipid peroksidasyonu ve antioksidan aktivite

Pages
53–58
Publication Date
2022-10-10
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the recent studies, antioxidant vitamin supplement can be required whether the antioxidant system doesn't step in against to the lipid peroxidation and this treatment could protect the life of mother and her fetus.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The formation of free radicals is a normal physiological course and free radicals which act on lipids cause to lipid peroxidation.
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Key Findings & Data:Nevertheless, all human body cells have developed a set of antioxidant defence system.
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Conclusion & Impact:According to the recent studies, antioxidant vitamin supplement can be required whether the antioxidant system doesn't step in against to the lipid peroxidation and this treatment could protect the life of mother and her fetus.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The formation of free radicals is a normal physiological course and free radicals which act on lipids cause to lipid peroxidation. Nevertheless, all human body cells have developed a set of antioxidant defence system. During pregnancy, the balance between lipid peroxidation and antioxidant defence system is also important as all terms of the human life for resuming the basic physiological functions of both mother and her fetus. Increasing on placental lipoperoxidative activity during pregnancy could effect the placenta and fetus unfavorably. In preeclamptic pregnancies, vasculer endothelial cell disfunction could rise the lipid peroxidation more dramatically. Therefore, intervening the antioxidant defence system is highly vital for the prognosis of the condition. According to the recent studies, antioxidant vitamin supplement can be required whether the antioxidant system doesn't step in against to the lipid peroxidation and this treatment could protect the life of mother and her fetus.

Özet

Serbest radikallerin oluşumu normal fizyolojik bir süreçtir ve bu serbest radikaller lipidler üzerinde lipid peroksidasyonuna yol açmaktadır. Bununla birlikte insan vücut hücreleri bir takım antioksidan savunma sistemleri geliştirmişlerdir. Lipid peroksidasyonu-antioksidan dengesi hayatın her evresinde olduğu gibi hamilelik döneminde de hem annenin hem de fetüsün fizyolojik fonksiyonlarını sürdürebilmesi için önem taşımaktadır. Hamilelik boyunca artan plasental lipoperoksidatif aktivite hem plasentaya hem de fetüse olumsuz etkiler yapmaktadır. Preeklamptik hamileliklerde ise vasküler endotel hücre disfonksiyonuna bağlı olarak lipid peroksidasyonundaki artış bu durumu çok daha dramatik bir hale getirmektedir. Bu yüzden antioksidan savunma sisteminin devreye girip girmemesi durumun seyri açısından oldukça önem taşımaktadır. Son yıllarda yapılan çalışmalarda, lipid peroksidasyonundaki yükselmeye karşın antioksidan sisteminin devreye girmediği durumlarda eksojen vitamin takviyesinin gerekebileceği ve bu müdahalenin hem annenin hem de fetüsün hayatı için koruyucu olabileceği belirtilmektedir.

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Cite This Article

YALIN, S., BERKÖZ, M. (2022). Lipid peroxidation and antioxidant activity in normal and preeclampsic pregnancies. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi, Cilt: 10 - Sayı: 2, 53–58. https://ajindex.com/articles/428965

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