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Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2011 / Cilt: 12 - Sayı: 2

The effect of single dose smoking on function and autoantibody levels against thyroid

Tek seferlik sigara içiminin tiroid fonksiyonlarına ve tiroid antikorlarına etkisi

Funda ÜSTÜN
Gülay DURMUŞ ALTUN
Deniz BEDEL
Şükran ÇİFTÇİ
Ömer Necmi YİĞİTBAŞI
Şakir BERKARDA
Pages
23–27
Publication Date
2022-10-10
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In ex-smokers, antithyroid peroxidase antiboy were higher than in non-smokers, and there was significant difference between ex-and non-smokers in pre- or post-smoking (p

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVES: Cigarette smoking has multiple different effects on thyroid function.
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Key Findings & Data:The aim of this study was to effect of one dose smoking on serum free triiodothyronine (fT3), free thyroxine (fT4), thyrotropin (TSH) and thyroid autoantibody levels in euthyroid patient population.MATERIALS and METHODS: We studied 31 euthyroid patients, 24 women and 7 men.
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Conclusion & Impact:In ex-smokers, antithyroid peroxidase antiboy were higher than in non-smokers, and there was significant difference between ex-and non-smokers in pre- or post-smoking (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVES: Cigarette smoking has multiple different effects on thyroid function. However, there is no literature data whether acute one dose cigarette smoking effect on the thyroid hormone and antibody levels. The aim of this study was to effect of one dose smoking on serum free triiodothyronine (fT3), free thyroxine (fT4), thyrotropin (TSH) and thyroid autoantibody levels in euthyroid patient population.MATERIALS and METHODS: We studied 31 euthyroid patients, 24 women and 7 men. Of these patients, 21 were ex-smokers, and 10 were non-smokers. Serum fT3, fT4, TSH and thyroid autoantibody levels were examined pre- and post-one dose cigarette smoking in each patient.RESULTS: Between ex-smokers and non-smokers groups, thyroid hormone and autoantibodies levels were not effect one dose smoking significantly (p>0.5). In ex-smokers, antithyroid peroxidase antiboy were higher than in non-smokers, and there was significant difference between ex-and non-smokers in pre- or post-smoking (p

Özet

AMAÇ: Sigara içiminin tiroid fonksiyonları üzerine pek çok farklı etkisi vardır. Ancak insanlarda akut tek doz sigara içiminin serum tiroid hormon ve antikor seviyelerine etkisi olup olmadığı hakkında literatür bilgisi yoktur. Bu çalışmada amaç ötiroid hasta grubunda tek sefer sigara içiminin serum serbest Triiodotironin (sT3), serbest Tiroksin (sT4), Tiriot stimülan hormon (TSH) düzeyi ile serum Anti-tiroglobulin antikor (anti Tg) ve Anti-tiroid peroksidaz antikor (anti TPO) düzeylerine etkisini belirlemekti.GEREÇ ve YÖNTEM: Çalışmaya ultrasonografik, biyokimyasal tetkikler ile sT3, sT4 ve TSH değerleri normal sınırlarda olan; 24'ü kadın, 7'si erkek 31 hasta dahil edildi. Bu hastaların 21'inin kronik sigara kullanım öyküsü varken 10'i hiç sigara kullanmamıştı. Çalışma grubunda yer alan gönüllülerden sigara öncesi ve tek sefer sigara içimi sonrası sT3, sT4, TSH, anti Tg ve anti TPO düzeyleri için kan alındı.BULGULAR: Sigara içen ve içmeyen gruplarda kendi grupları içinde başlangıç ve sigara sonrası tiroid hormon düzeyleri ve antikor ölçüm değerleri arasında anlamlı farklılık bulunmamıştır (p>0.5). Sigara içen hastaların içmeyen hastalara göre başlangıç ve sigara sonrası anti TPO değerlerinin yüksek olduğu görülmüştür. Tek doz sigara içimi öncesi anti TPO değerleri sigara içen ve içmeyen grup arasında anlamlı olarak farklıdır (p

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Cite This Article

ÜSTÜN, F., ALTUN, G. D., BEDEL, D., ÇİFTÇİ, Ş., YİĞİTBAŞI, Ö. N., BERKARDA, Ş. (2022). The effect of single dose smoking on function and autoantibody levels against thyroid. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi, Cilt: 12 - Sayı: 2, 23–27. https://ajindex.com/articles/428917

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