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Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2011 / Cilt: 12 - Sayı: 2

The ıncidence of residual neuromuscular blockade associated with single dose of ıntermediate-acting non-depolarizing neuromuscular blocking

Tek doz orta etkili kas gevşeticilere bağlı postoperatif rezidüel nöromusküler blok insidansı ve etki eden faktörler

Nil KAAN
Özlem KOCATÜRK
İbrahim KURT
Halil ÇİÇEK
Emel MEMETOĞLU
Pages
17–22
Publication Date
2022-10-10
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The median length of anesthesia was 80 minutes.

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Objective & Hypothesis:PURPOSE: The goal of this study is to investigate the incidence of postoperative residual neuromuscular blockade (PRNB) associated with single-dose intermediate-acting muscle relaxants (atracurium, vecuronium, rocuronium) administered to adult patients for endotracheal intubation during early postoperative period and subsequent factors affecting this.MATERIALS and METHODS: This prospective and observational study was conducted after obtaining the permission of the local ethics committee.
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Key Findings & Data:Train-of-four (TOF) ratios under 0.9 were recorded as “PRNB present”.
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Conclusion & Impact:The median length of anesthesia was 80 minutes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

PURPOSE: The goal of this study is to investigate the incidence of postoperative residual neuromuscular blockade (PRNB) associated with single-dose intermediate-acting muscle relaxants (atracurium, vecuronium, rocuronium) administered to adult patients for endotracheal intubation during early postoperative period and subsequent factors affecting this.MATERIALS and METHODS: This prospective and observational study was conducted after obtaining the permission of the local ethics committee. Adult, ASA I, II patients who received a single dose of vecuronium, atracurium or rocuronium during general anesthesia for elective surgical procedure were included in the study. The decisions about the anesthetics and muscle relaxants used on the patients, reversal with neostigmine, extubation and transfer to the recovery room were left to be made by the anesthesiologist following the patient. The patient who was taken into the recovery room had neuromuscular monitoring using accelomyography. Train-of-four (TOF) ratios under 0.9 were recorded as “PRNB present”. Age, weight, gender, reversal, anesthesia duration, time for transfer to the recovery room after extubation were considered risk factors for PRNB, stepwise logistic regression analysis was conducted.RESULTS: This study included 84 patients and the number of patients that were given vecuronium, atracurium, rocuronium were 29, 28, and 27, respectively. After the end of the operation, reversal was performed with neostigmine in 58.3% of the patients. The median length of anesthesia was 80 minutes. PRNB incidence (TOF

Özet

AMAÇ: Bu çalışmanın amacı sağlıklı, erişkin hastalarda endotrakeal entübasyon için uygulanan tek doz orta etki süreli kas gevşeticilerine (atrakuryum, vekuronyum ve rokuronyum) bağlı erken postoperatif rezidüel nöromusküler blok (PRNB) insidansını ve buna etki eden sonra faktörleri araştırmaktır.GEREÇ ve YÖNTEM: Çalışma prospektif, gözlemsel olarak, anestezi sırasında sadece endotrakeal entübasyonu kolaylaştırmak için tek doz vekuronyum, atrakuryum veya rokuronyum kullanılan ve ameliyat bittikten sonra derlenme odasına alınan hastalarda yapıldı. Derlenme odasında akselomiyograf ile nöromusküler ileti monitorize edildi ve dörtlü uyarıya yanıt (TOF) oranı ölçüldü; 0,9'un altındaki değerler “PRNB var” olarak kaydedildi. Hastalara kullanılan anestezikler ve kas gevşeticisinin seçimi, antidot (neostigmin) kullanımı, ekstübasyon ve derlenme odasına alınma kararları hastayı takip eden anestezi doktoruna bırakıldı. Yaş, kilo, cinsiyet, antidot kullanımı, anestezi süresi, ekstübasyondan sonra derlenme odasına alınma süreleri PRNB için risk faktörü olarak alındı, stepwise lojistik regresyon analizi yapıldı.BULGULAR: Çalışmaya 84 hasta alındı, vekuronyum, atrakuryum, rokuronyum kullanılan hasta sayısı sırasıyla 29, 28, 27 oldu. Hastaların % 58,3'ne neostigmin yapıldı. Medyan anestezi süresi 80 dakikaydı. Derlenme odasında PRNB insidansı (TOF

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Cite This Article

KAAN, N., KOCATÜRK, Ö., KURT, İ., ÇİÇEK, H., MEMETOĞLU, E. (2022). The ıncidence of residual neuromuscular blockade associated with single dose of ıntermediate-acting non-depolarizing neuromuscular blocking. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi, Cilt: 12 - Sayı: 2, 17–22. https://ajindex.com/articles/428904

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References (13)

  1. Murphy GS, Brull SJ. Residual neuromuscular block: Lessons unlearned. Part I: Definitions, incidence, and adverse physiologic effects of residual neuromuscular block. Anesth Analg 2010;111:120-8
  2. Naguib M. Pharmacology of muscle relaxant and their antagonist neuromuscular physiology and pharmacology. In: Miller RD, ed. Anaesthesia. 6th ed. Philadelphia, Churchil Livingston, 2006:481-572
  3. Murphy GS. Residual neuromuscular blockade: incidence, assessment, and relevance in the postoperative period. Minevra Anestesiol 2006;72:97-109
  4. Murphy GS, Szokol JW, Marymont JH, Greenberg SB, Avram MJ, Vender JS. Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit. Anesth Analg 2008;107:130-7
  5. Murphy GS, Szokol JW, Franklin M, Marymont JH, Avram MJ, Vender JS. Postanesthesia Care unit recovery times and neuromuscular blocking drugs: a prospective study of orthopedic surgical patients randomized to receive pancuronium or rocuronium. Anesth Analg 2004;98:193-200
  6. Eikermann M, Groeben H, Hüsing J, Peters J. Accelerometry of adductor pollicis muscle predicts recovery of respiratory function from neuromuscular blockade. Anesth 2003;98:1333-7
  7. Eriksson LI, Satoo M, Severinghaus JW. Effect of vecuronium induced partial neuromuscular block on hipoxic ventilatory response. Anesth 1993;78:693-9
  8. Naguib M, Kopman AF, Ensor JE. Neuromuscular monitoring and postoperative residual curarisation: a meta-analysis. Br J Anaesth 2007;98:302-16
  9. Tsai CC, Chung HS, Chen PL, Yu CM, Chen MS, Hong CL. Postoperative residual curarization: Clinical observation in the post-anesthesia care unit. Chang Gung Med J 2008;31:364-8, 10) Houghton IT, Aun CS, Oh TE. Vecuronium: an anthropometric comparison. Anaesth 1992;47:741-6
  10. Semple P, Hope DA, Clyburn P, Rodbert A. Relative potency of vecuronium in male and female patients in Britain and Australia. Br J Anaesth 1994;72:190-4
  11. Xue F, Liao X, Liu J et al. Dose-response curve and timecourse of effect of vecuronium in male and female patients. Br J Anaesth 1998;80:720-4
  12. Xue FS, An G, Liao X, Zou Q, Luo LK. The pharmacokinetics of vecuronium in male and female patients. Anesth Analg 1998;86:1322-7
  13. M. Adamus, T. Gabrhelik, O. Marek. Influence of gender on the course of neuromuscular block following a single bolus dose of cisatracurium or rocuronium. Eur J Anaesth 25: 589–595 15) Xue FS, Tong SY, Liao X, Liu JH, An G, Luo LK. Doseresponse and time course of effect of roc