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Journals / Adıyaman Üniversitesi Fen Bilimleri Dergisi / 2018 / Cilt: 8 - Sayı: 1

The Protective Effects of Silymarin on D-Galactosamine/Tumor Necrosis FactorAlpha-Induced Oxidative Stress and Lung Injury in Mice

D-Galaktozamin/Tümör Nekroz Faktör Alfa Nedenli Oksidatif Stress ve Akciğer Hasarı Üzerine Silmarinin Koruyucu Etkileri

Mustafa CENGİZ
Pages
42–52
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, Smimproves degenerative alterations in injured lung owing to D-GalN/TNF-a.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Silymarin (Sm) is known for its anti-oxidative, anti-inflammatory, and antimitoticactivities against a broad range of cancers, such as prostate, colon, ovarian, skinand lung cancer.
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Key Findings & Data:The study groupswere given saline (0.5 mL), D-GalN/TNF-a, and D-GaIN/TNF-α plus Sm, respectively.Our biochemistry, apoptotic markers and light microscopic findings offer that Sm cannoticeably diminish D-GaIN/TNFα-induced pulmonary toxicity.
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Conclusion & Impact:In conclusion, Smimproves degenerative alterations in injured lung owing to D-GalN/TNF-a.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Silymarin (Sm) is known for its anti-oxidative, anti-inflammatory, and antimitoticactivities against a broad range of cancers, such as prostate, colon, ovarian, skinand lung cancer. This study targets to determine the protective effects of Sm on lungdamage in the mice exposed to D-galactosamine (D-GaIN)/tumour necrosis factor alpha(TNF-α). For this purpose, three groups of Balb/c mice were used. The study groupswere given saline (0.5 mL), D-GalN/TNF-a, and D-GaIN/TNF-α plus Sm, respectively.Our biochemistry, apoptotic markers and light microscopic findings offer that Sm cannoticeably diminish D-GaIN/TNFα-induced pulmonary toxicity. In conclusion, Smimproves degenerative alterations in injured lung owing to D-GalN/TNF-a. This caringeffect might be thanks to the capability of Sm to keep oxidant–antioxidant stability.

Özet

Silymarin (Sm), prostat, kolon, yumurtalık, deri ve akciğer kanseri gibi çok çeşitli kanserlerin tedavisinde kullanılan anti-oksidatif, anti-inflamatuar ve anti-mitotik aktiviteleri ile bilinen bir bileşiktir. Bu çalışma, D-galaktosamin (D-GaIN) / tümör nekrozis faktör alfa (TNF-α) nedenli oksidatif stress ve akciğer hasarı üzerinde Sm’nin koruyucu etkilerini belirlemeyi amaçlamaktadır. Bu amaçla 21 adet Balb / c cinsi erek fare kullanıldı (n=7). Çalışma gruplarına sırasıyla serum fizyolojik (0.5 mL), D-GalN / TNF-a ve D-GaIN / TNF-α artı Sm verildi. Biyokimyasal, histopatolojik ve apoptotik bulgularımıza göre, Sm'nin D-GaIN / TNF-a nedenli pulmoner toksisiteyi ve oksidatif stressi belirgin olarak azaltabildiğini göstermektedir. Sonuç olarak, Sm, D-GalN / TNFa'ya bağlı akciğerde meydana gelen dejeneratif değişiklikleri olumlu yönde iyileştirdiği görülmüştür. Sm’nin bu etkisi, oksidan-antioksidan stabilitesini koruma özelliğinden dolayı olduğunu düşünmekteyiz.

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Cite This Article

CENGİZ, M. (2022). The Protective Effects of Silymarin on D-Galactosamine/Tumor Necrosis FactorAlpha-Induced Oxidative Stress and Lung Injury in Mice. Adıyaman Üniversitesi Fen Bilimleri Dergisi, Cilt: 8 - Sayı: 1, 42–52. https://ajindex.com/articles/428506

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