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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2021 / Cilt: 45 - Sayı: 3

VALIDATION STUDY OF A SPECTROPHOTOMETRIC BINARY MIXTURE ANALYSIS

BİR SPEKTROFOTOMETRİK İKİLİ KARIŞIM ANALİZİNİN DOĞRULAMA ÇALIŞMASI

Özgür ÜSTÜNDAĞ
Erdal DİNÇ
Pages
545–553
Publication Date
2021-09-27
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These studies have shown that the validity and applicability of the method is good.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: A rapid spectrophotometric analysis by applying a signal processing method was validated by intra-day and inter-day experiments, standard addition technique, recovery study and analysis of variance (ANOVA).
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Key Findings & Data:Material and Method: The absorption spectra of mixtures and tablet solutions in the spectral range 200-305 nm were measured by a Shimadzu UV-1601 dual-beam UV-VIS spectrophotometer with a constant gap width (2 nm).
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Conclusion & Impact:These studies have shown that the validity and applicability of the method is good.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İkili karışım · kantitatif tayin · sinyal işleme

Abstract

Objective: A rapid spectrophotometric analysis by applying a signal processing method was validated by intra-day and inter-day experiments, standard addition technique, recovery study and analysis of variance (ANOVA). For this purpose, a binary pharmaceutical formulation was evaluated consisting of candesartan cilexetil (CC) and hydrochlorothiazide (HT). Material and Method: The absorption spectra of mixtures and tablet solutions in the spectral range 200-305 nm were measured by a Shimadzu UV-1601 dual-beam UV-VIS spectrophotometer with a constant gap width (2 nm). Result and Discussion: Intra-day and inter-day experiments, standard addition technique, recovery study and analysis of variance (ANOVA) studies were carried out by using artificial mixtures were prepared for this purpose. These studies have shown that the validity and applicability of the method is good.

Özet

Amaç: Bir sinyal işleme yöntemi uygulanarak hızlı bir spektrofotometrik analiz, gün içi ve günler arası deneyler, standart ekleme tekniği, geri kazanım çalışması ve varyans analizi (ANOVA) ile doğrulanmıştır. Bu amaçla, kandesartan sileksetil (CC) ve hidroklorotiyazidden (HT) oluşan ikili bir farmasötik formülasyon değerlendirildi.

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Cite This Article

ÜSTÜNDAĞ, Ö., DİNÇ, E. (2021). VALIDATION STUDY OF A SPECTROPHOTOMETRIC BINARY MIXTURE ANALYSIS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 45 - Sayı: 3, 545–553. https://ajindex.com/articles/394669

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References (2)

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