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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 1985 / Cilt: 15 - Sayı: 1

Studies on the Synthesis and In vitro Antibacterial Activities of 2-(p-Substitutedphenyl)-3H-Imidazo (4,5-b) and (4,5-c ) Pyridine Derivatives

2- (p-Sübstitüefenil)-3H-tmidazo ( 4,5-b) ve (4,5-c) Pir idin Türevlerinin Sentezleri ve İn vitro Antibakteriyel Etkileri Üzerinde Bir Çalışma

Seçkin ÖZDEN
Tuncel ÖZDEN
Fatma GÜMÜŞ
Seniha -AKIN
Pages
79–90
Publication Date
1985-06-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Amon g the compound ssynthesized, the antibacterial activity of 2-(p-efhylphenyl)-3Himidazo (4,5—b) pyridine (Compou d Ic ) against Bacillus anthracis (MIC : 500 µg/ml) and Bacillus subtilis (MIC : 1000 µg/ml) was found noteworthy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this research, nine, 2-(p-substitutedphenyl)-3H-imidazo (4, 5-b) pyridines were prepared and 2 of them were original.
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Key Findings & Data:After the structure elucidation, using instrumental analysis, the antibacterial activities of these compound s and eleven, 2-(p-substituted)-3H— imidazo (4,5-c) pyridines of which synthesis and structure elucidation were reported previously, have been tested.
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Conclusion & Impact:Amon g the compound ssynthesized, the antibacterial activity of 2-(p-efhylphenyl)-3Himidazo (4,5—b) pyridine (Compou d Ic ) against Bacillus anthracis (MIC : 500 µg/ml) and Bacillus subtilis (MIC : 1000 µg/ml) was found noteworthy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anahtar Kelimeler 2 - ( p - S ü b s t i t ü e f e n i l ) - 3 H - i m i d a z o ( 4 · 5 - b ) · ( 4

Abstract

In this research, nine, 2-(p-substitutedphenyl)-3H-imidazo (4, 5-b) pyridines were prepared and 2 of them were original. After the structure elucidation, using instrumental analysis, the antibacterial activities of these compound s and eleven, 2-(p-substituted)-3H— imidazo (4,5-c) pyridines of which synthesis and structure elucidation were reported previously, have been tested. Amon g the compound ssynthesized, the antibacterial activity of 2-(p-efhylphenyl)-3Himidazo (4,5—b) pyridine (Compou d Ic ) against Bacillus anthracis (MIC : 500 µg/ml) and Bacillus subtilis (MIC : 1000 µg/ml) was found noteworthy.

Özet

Bu çalışmada; 2-(p-sübstitüefenil)-3H-imidazo (4,5-b) piridin yapısında 2 si orijinal, 9 bileşik hazırlanmıştır. Bu bileşiklerin yapıları aletli analiz yöntemleri ile açıklandıktan sonra, sentez ve yapı açıklamaları daha önceki bir çalışmada verilen, 2-(p-sübstitüefenil)-3Himidazo (4,5-c ) piridin türevi 11 bileşik ile birlikte antibakteriyel etkileri incelenmiştir. Bileşiklerden 2-(p-etilfenil)-3H-imidazo (4,5-b) piridinin (Bileşik Ic ) Bacillus anthracis'e (MİK : 500 µg/ml) ve Bacillus subtilis'e (MİK : 1000 µg/ml) karşı antibakteriyel etkisi dikkate değer bulunmuştur.

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Cite This Article

ÖZDEN, S., ÖZDEN, T., GÜMÜŞ, F., -AKIN, S. (1985). Studies on the Synthesis and In vitro Antibacterial Activities of 2-(p-Substitutedphenyl)-3H-Imidazo (4,5-b) and (4,5-c ) Pyridine Derivatives. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 15 - Sayı: 1, 79–90. https://ajindex.com/articles/38831

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