AI Summary & Key Takeaways
AI InsightThe results indicate that Eudragit RL/RS (1:1) combination was found more suitable than CAP as a matrix material.
📌 3 Key Takeaways
Abstract
Indomethacin (IM) sustained release suppositories were prepared by using a solid matrix of cellulose acetate phythalate (CAP) and trimethylamonium methacrylate chloride's (Eudragit RL and RS) as poorly soluble cariers. Witepsol H15 and polyethylene glycol (PEG) mixtures were used as examples of hydrophobic and hydrophilic bases, respectively. Disintegration time, fracture point and release experiments were conducted on the formulations. The results indicate that Eudragit RL/RS (1:1) combination was found more suitable than CAP as a matrix material. From the kinetic assesment of release data, the best fit was achieved with Q t kinetic
Özet
İndometazinin sürekli etkili suppozituvarları suda çözünmeyen taşıyıcı olan selüloz asetat ftalat (CAP) ve Eudragit RL/RS kullanılarak hazırlandı. Witepsol H15 ve polietilen glikol (PEG) karışımları hidrofobik ve hidrofilik sıvağlar olarak seçildi. Formülasyonlar üzerinde dağılma zamanı, sertlik ve salım deneyleri yapıldı. Sonuçlar matriks materyali olarak Eudragit RL/RS (1:1) karışımının CAP'tan daha uygun olduğunu gösterdi. Salım deneylerinin kinetik değerlendirilmesinde en iyi uyum Q t kinetiği ile elde edildi