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Journals / Tıp Araştırmaları Dergisi / 2014 / Cilt: 12 - Sayı: 3

The Role of Oxidized LDL Receptor-1 and Its Association with Cardiovascular Diseases

Okside LDL Reseptörü-1 (LOX-1) ve Kardiyovasküler Hastalıklarla İlişkisi

ÖZLEM KURNAZ GÖMLEKSİZ
Hülya YILMAZ AYDOĞAN
Pages
145–152
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

So that, Lectin like oxidized LDL receptor-1 attracts the attention of researchers for the atherosclerosis and related diseases as a target gene and protein due to be a receptor for oxidized LDL and its direct effect on oxidized LDL metabolism.

📌 3 Key Takeaways

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Objective & Hypothesis:High plasma and tissue levels of oxidized LDL are added to traditional risk factors of atherosclerosis that is important in pathophysiology of cardiovascular disease.
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Key Findings & Data:It is reported that oxidized LDL levels increased in pathological conditions such as Acute Myocardial Infarct and coronary artery disease.
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Conclusion & Impact:So that, Lectin like oxidized LDL receptor-1 attracts the attention of researchers for the atherosclerosis and related diseases as a target gene and protein due to be a receptor for oxidized LDL and its direct effect on oxidized LDL metabolism.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

High plasma and tissue levels of oxidized LDL are added to traditional risk factors of atherosclerosis that is important in pathophysiology of cardiovascular disease. It is shown oxidized LDL gives rise to dysfunction of vascular endothelial cells and enables the monocytes entry to vessel wall by increasing proinflammatory genes expression. It is reported that oxidized LDL levels increased in pathological conditions such as Acute Myocardial Infarct and coronary artery disease. This activity of oxidized LDL is regulated by a receptor family called scavenger receptors. Lectin like oxidized LDL receptor-1 was firstly described as the main receptor for oxidized LDL in endothelial cells by Sawamura et al. in 1997. This receptor is considered to be a crucial molecule for binding, internalization and degradation of oxidized LDL. Lectin like oxidized LDL receptor-1 is expressed in arterial endothelial cells, macrophages, vascular smooth muscle cells, monocytes, platelets and fibroblasts. The mechanism of Lectin like oxidized LDL receptor-1 affects the CAD risk is still unclear. So that, Lectin like oxidized LDL receptor-1 attracts the attention of researchers for the atherosclerosis and related diseases as a target gene and protein due to be a receptor for oxidized LDL and its direct effect on oxidized LDL metabolism.

Özet

Kardiyovasküler hastalıkların patofizyolojisinde çok önemli yer tutan aterojenezin geleneksel risk faktörlerine günümüzde okside LDL'nin yüksek plazma ve doku düzeyleri de eklenmiştir. Okside LDL'nin pro-inflamatuar genlerin ekspresyonunu arttırarak damar duvarına monosit girişine ve vasküler endotel hücrelerinde fonksiyon bozukluğuna neden olduğu gösterilmiştir. Akut Miyokard infarktüsü (AMİ) ve koroner arter hastalığı (KAH) gibi bazı patolojik durumlarda okside LDL düzeyinin arttığı bildirilmiştir. Okside LDL'nin bu aktivitesi çöpçü reseptörler olarak adlandırılan bir reseptör ailesi tarafından düzenlenir. İlk olarak Sawamura ve ark. 1997'de endotel hücrelerinde okside LDL için başlıca reseptörün LOX-1 olduğunu tanımlamışlardır. Bu reseptör okside LDL'nin endotel hücrelerine bağlanma, internalize olma ve yıkılımından sorumlu önemli bir molekül olarak kabul edilmektedir. LOX-1'in büyük arterlerin endotel hücreleri, makrofajlar, vasküler düz kas hücreleri, monositler, trombositler ve fibroblastlarda da eksprese edildiği ve okside LDL'ye bağlandığı gösterilmiştir. LOX-1'in KAH riskini etkilediği mekanizma henüz tam olarak aydınlatılamamıştır. Bu nedenle LOX-1 reseptörü, aterosklerozun en önemli etmeni olan okside LDL'nin reseptörü olması ve okside LDL metabolizmasında direkt etkisi ile ateroskleroz ve ilişkili hastalıklarda hedef gen ve protein olarak araştırmacıların ilgisini çekmektedir.

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Cite This Article

GÖMLEKSİZ, Ö. K., AYDOĞAN, H. Y. (2014). The Role of Oxidized LDL Receptor-1 and Its Association with Cardiovascular Diseases. Tıp Araştırmaları Dergisi, Cilt: 12 - Sayı: 3, 145–152. https://ajindex.com/articles/361964

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