Journals / Tıp Araştırmaları Dergisi / 2010 / Cilt: 8 - Sayı: 3

Pankreas adenokarsiyomlu hastalarda pankıraatik sıvıdaki matriks metalloproteinaz-2 düzeyleri

The levels of Mmp-2 in pancreatıc juıce from pancreatıc adenocarcınoma patients

Pages
177–179
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The measurement of pancreatic juice MMP-2 might be clinically useful for pancreatic adenocarcinoma.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:There is specific biomarker to improve early diagnosis and screen high-risk patients for pancreatic adenocarcinoma.
📊
Key Findings & Data:To identify potential biomarker as MMP-2, these levels were determined by enzyme linked immunosorbent assay to compare the pancreatic juice from 10 panceratic adenocarcinoma patients and 10 cancer-free controls.
💡
Conclusion & Impact:The measurement of pancreatic juice MMP-2 might be clinically useful for pancreatic adenocarcinoma.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

There is specific biomarker to improve early diagnosis and screen high-risk patients for pancreatic adenocarcinoma. Pancreatic juice is an ideal specimen for pancreatic adenocarcinoma biomarkers discovery, because it is an exceptionally rich source of proteins released from pancreatic adenocarcinoma. To identify potential biomarker as MMP-2, these levels were determined by enzyme linked immunosorbent assay to compare the pancreatic juice from 10 panceratic adenocarcinoma patients and 10 cancer-free controls. Pancreatic juice MMP-2 levels were significantly higher in pancreatic adenocarcinoma patients than in controls (p<0.001). MMP-2 levels are elevated in pancreatic juice from pancreatic adenocarcinoma, which suggest its further utility in pancreatic adenocarcinoma diagnosis and screening. The measurement of pancreatic juice MMP-2 might be clinically useful for pancreatic adenocarcinoma.

Özet

Pankreas kanseri için erken teşhis edilebilecek ve yüksek riskli hasta grubunda özel bir biomarkır yoktur. Pankreastan salınan proteinlerin bulunduğu zengin bir kaynak olan panreatik sıvı, pancreas kanserinin biyolojik keşfi için ideal bir kaynaktır. 10 pankreatik adenokarsinomalı hasta ve 10 sağlıklı bireyde pancreas suyu alınarak, MMP-2 düzeyleri enzim bağlı immunosorbent ölçüm yöntemi (ELISA) ile belirlendi. Pankreas salgısı MMP-2 düzeyleri, kontrol grubuna göre, pancreas kanserli hastalarda yüksek bulundu (p<0.001). MMP-2 düzeyleri pancreas kanserinin tanımlanmasında ve taramasında yarar sağlayacak, klinik uygulamaya konabilecek bir markırdır.

🔖

Cite This Article

KEMİK, Ö., BEĞENDİK, H., KEMİK, A. S., PURİSA, S., ADAŞ, M., HASIRCI, İ., DÜLGER, A., TÜZÜN, S. (2010). Pankreas adenokarsiyomlu hastalarda pankıraatik sıvıdaki matriks metalloproteinaz-2 düzeyleri. Tıp Araştırmaları Dergisi, Cilt: 8 - Sayı: 3, 177–179. https://ajindex.com/articles/361640

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (4)

  1. Gronborg M, Bunkenborg J, Kristiansen TZ, Jensen ON, Yeo CJ, et al. Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res 2004; 3(5): 1042-1055
  2. Chen R, Pan S, Yi EC, Donohoe S, Bronner MP, Potter JD, Goodlett DR, Aebersold R, Brentnall TA. Quantitative proteomic profiling of pancreatic cancer juice. Proteomics 2006; 6(13): 3871-3879
  3. Rosty C, christa L, Kuzdzal S, Baldwin WM, et al. Identification of pancreatitis-associated protein 1 as a biomarker for pancreatic adenocarcinoma by protein biochip technology. Cancer Res 2002; 62(6): 1868-1875
  4. Kuniyasu H, Ellis LM, Evans DB, Abbruzzese JL, Fenoglio CJ, Bucana CD, Cleary KR, Tahara E, Fidler IJ. Relative expression of Ecadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma. Clin Cancer Res 1999; 5(1): 25-33.