Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2012 / Cilt: 22 - Sayı: 3

Non-Mastektomize sol meme kanseri radyoterapisinde aktif nefes kontrolü-orta derin inspirasyonda nefes tutma kullanımının rolü: Dozimetrik bir değerlendirme

The role of Active Breathing Control-moderate deep inspiration breath-hold (ABC-mDIBH) usage in non-mastectomized left-sided breast cancer radiotherapy: A dosimetric evaluation

Pages
147–155
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This respiratory management strategy is a promising tool that may be routinely used for the treatment of patients with early-stage left-sided breast cancer.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study is to evaluate the dosimetric impact of utilizing Active Breathing Control-moderate deep inspiration breath- hold (ABC-mDIBH) technique in early-stage left-sided breast cancer radiotherapy (RT).
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Key Findings & Data:Twenty-five patients with left-sided early-stage breast cancer undergoing breast-conserving surgery referred to our department for adjuvant radiotherapy between October 2010 and October 2011 were scanned with computed tomography (CT)-simulator at free breathing (FB) and ABC-mDIBH for radiation treatment planning.
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Conclusion & Impact:This respiratory management strategy is a promising tool that may be routinely used for the treatment of patients with early-stage left-sided breast cancer.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Mastektomi · segmental · Solunum

Abstract

The aim of this study is to evaluate the dosimetric impact of utilizing Active Breathing Control-moderate deep inspiration breath- hold (ABC-mDIBH) technique in early-stage left-sided breast cancer radiotherapy (RT). Twenty-five patients with left-sided early-stage breast cancer undergoing breast-conserving surgery referred to our department for adjuvant radiotherapy between October 2010 and October 2011 were scanned with computed tomography (CT)-simulator at free breathing (FB) and ABC-mDIBH for radiation treatment planning. Two separate treatment plans were generated for each patient, with and without ABC-mDIBH to comparatively evaluate dose-volume parameters of both plans. Dose-volume parameters of lung, heart, left anterior descending artery (LAD), contralateral breast and spinal cord were significantly reduced with ABC-mDIBH compared to free breathing (p< 0.001). The use of ABC-mDIBH technique in the practice of early-stage left-sided breast cancer radiotherapy improves critical organ sparing with the dosimetrically-confirmed potential to decrease treatment-related morbidity and mortality. This respiratory management strategy is a promising tool that may be routinely used for the treatment of patients with early-stage left-sided breast cancer.

Özet

Bu çalışmanın amacı erken evre sol meme kanseri radyoterapisinde aktif nefes kontrolü-orta derin inspirasyonda nefes tutma tekniğinin dozimetrik olarak değerlendirilmesidir. Ekim 2010 ile Ekim 2011 tarihleri arasında erken evre sol meme kanserli, meme koruyucu cerrahi uygulanmış 25 hastanın, 2 ayrı solunum fazında radyasyon tedavisinin çevre kritik organlara olan etkisinin dozimetrik değerlendirmesine yönelik olarak serbest solunum ve aktif nefes kontrollü tomografik simulasyon planlama görüntüleri alınmış ve her hasta için 2 ayrı tedavi planı oluşturularak her iki plandan elde edilen kritik organların doz-volüm parametreleri karşılaştırmalı olarak değerlendirilmiştir. Aktif nefes kontrolü-orta derin inspirasyonda nefes tutma tekniğinin eklenmesiyle kritik organlar olan akciğerler, kalp, sol ön inen arter, karşı meme ve spinal kordun aldığı dozlarda serbest solunuma göre anlamlı azalma saptanmıştır (p< 0.001). Erken evre sol meme kanseri radyoterapisinde aktif nefes kontrolü- orta derin inspirasyonda nefes tutma tekniğinin kullanılması, tedaviyle ilişkili beklenen morbidite ve mortaliteyi azaltma potansiyeli açısından dozimetrik olarak kritik organ korumasını iyileştirmiştir. Bu solunum manajmanı stratejisi erken evre korunmuş sol meme kanserli hastaların tedavisinde rutin olarak kullanılabilecek umut vadeden bir yöntemdir.

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Cite This Article

SAĞER, Ö., BEYZADEOĞLU, M. M., DINCOGLAN, F., OYSUL, K., ELCIM, Y. K., GAMSIZ, H., UYSAL, B., DEMİRAL, S., DİRİCAN, B., SÜRENKÖK, S. (2012). Non-Mastektomize sol meme kanseri radyoterapisinde aktif nefes kontrolü-orta derin inspirasyonda nefes tutma kullanımının rolü: Dozimetrik bir değerlendirme. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 22 - Sayı: 3, 147–155. https://ajindex.com/articles/323190

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